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- What is mesalamine (Lialda), and how does it work (mechanism of action)?
- What brand names are available for mesalamine (Lialda)?
- Is mesalamine (Lialda) available as a generic drug?
- Do I need a prescription for mesalamine (Lialda)?
- What are the uses for mesalamine (Lialda)?
- What are the side effects of mesalamine (Lialda)?
- What is the dosage for mesalamine (Lialda)?
- Which drugs or supplements interact with mesalamine (Lialda)?
- Is mesalamine (Lialda) safe to take if I'm pregnant or breastfeeding?
- What else should I know about mesalamine (Lialda)?
What is mesalamine (Lialda), and how does it work (mechanism of action)?
- Mesalamine is an oral drug used for treating ulcerative colitis.
- Lialda is mesalamine in a form that is slowly released in the intestine so that it can be given just once-a-day.
- Other oral drugs containing mesalamine that are similar to Lialda include Asacol, Pentasa, and Apriso.
- Asacol and Pentasa, however, are given as multiple daily doses.
- The exact mechanism of mesalamine is not known but is believed to be by reducing inflammation in the colon.
- Ulcerative colitis and other inflammatory diseases cause excessive production of chemicals (i.e., prostaglandins) that produce inflammation in the colon.
- Prostaglandins are produced by cyclooxygenase and lipoxygenase enzymes.
- These enzymes are over-active in individuals with ulcerative colitis.
- Mesalamine may work by blocking the activity of cyclooxygenase and lipoxygenase, therefore, reducing the production of prostaglandins.
- Reduced prostaglandin production reduces inflammation in the colon and other symptoms associated with ulcerative colitis.
- The FDA approved Lialda in January 2007.
What are the uses for mesalamine (Lialda)?
Lialda is used for inducing remission in patients with active, mild to moderate ulcerative colitis. In clinical studies which compared mesalamine against placebo for 8 weeks, more patients in the mesalamine group achieved remission.
What are the side effects of mesalamine (Lialda)?
The most common side effects are:
Other less common side effects include:
- increased heart rate,
- back pain,
- ear pain,
- blood disorders, and
- kidney dysfunction.
Possible serious side effects include an acute intolerance syndrome that resembles a flare of inflammatory bowel disease. Symptoms include:
Quick GuideUlcerative Colitis Symptoms, Causes, and Treatment
What is the dosage for mesalamine (Lialda)?
The recommended dose is 2.4 g or 4.8 g once daily with a meal. Tablets should be swallowed whole without breaking the coating.
Which drugs or supplements interact with mesalamine (Lialda)?
Specific drug interaction studies have not been conducted with Lialda. Other mesalamine medications have been associated with several drug interactions. Combining mesalamine with drugs that affect kidney function, for example, nonsteroidal antiinflammatory drugs (for example, ibuprofen), may increase the likelihood of kidney dysfunction. Concurrent use of mesalamine and 6-mercaptopurine or azathioprine (Imuran) may increase the likelihood of blood disorders. Mesalamine may increase the blood thinning effect of warfarin (Warfarin).
Is mesalamine (Lialda) safe to take if I'm pregnant or breastfeeding?
There are no adequate human studies of mesalamine use during pregnancy. Mesalamine is known to cross the placenta into the fetus, but animal studies revealed no evidence of harm to the fetus. Mesalamine should only be used during pregnancy if it is felt that the benefit of its use justifies the unknown risks. Mesalamine is excreted in breast milk. Mesalamine should only be used by nursing mothers if it is felt that the benefit of its use justifies the risk.
What else should I know about mesalamine (Lialda)?
What preparations of mesalamine (Lialda) are available?
Tablets: 1.2 g
How should I keep mesalamine (Lialda) stored?
Store at room temperature, 15 C - 25 C (59 F - 77 F)
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Crohns Disease vs Ulcerative Colitis UC
Crohn's disease and ulcerative colitis are diseases that cause inflammation of part of or the entire digestive tract (GI). Crohn's affects the entire GI tract (from the mouth to the anus), while ulcerative colitis or UC only affects the large and small intestine and ilium. Researchers do not know the exact cause of either disease. About 20% of people with Crohn's disease also have a family member with the disease. Researchers believe that certain factors may play a role in causing UC. Both Crohn's disease and ulcerative colitis are a type of inflammatory bowel disease, or IBD.
Crohn's disease and ulcerative colitis both have similar symptoms and signs, for example:
- Loss of appetite
- Weight loss
- Episodic and/or persistent diarrhea
- Abdominal pain and cramping
- Rectal bleeding
- Bloody stools
- Joint pain and soreness
- Eye redness or pain
Symptoms unique to Crohn's disease include:
- Skin changes
Symptoms of unique to ulcerative colitis include:
- Certain rashes
- An urgency to defecate (have a bowel movement)
Doctors diagnose both diseases with similar tests and procedures. While there is no cure for either disease, doctors and other health care professionals can help you treat disease flares, and manage your Crohn's or UC with medication, diet, nutritional supplements, and/or surgery.
CDC. "What is inflammatory bowel disease IBD?" Updated June 21, 2017.
NIH. National Institute of Diabetes and Digestive and Kidney Diseases. "Ulcerative Colitis." September 2014.
NIH. National Institute of Diabetes and Digestive and Kidney Diseases. "Symptoms and Causes of Crohn's Disease." November 2016.
NIH. National Human Genome Research Institute. "Learning About Crohn's Disease." Updated: Sep 27, 2011.
PubMed Health. "Ulcerative Colitis." Accessed Jul 24, 2017.
Inflammatory Bowel Disease: Intestinal ProblemsThe inflammatory bowel diseases (IBD) are Crohn's disease (CD) and ulcerative colitis (UC). The intestinal complications of Crohn's disease and ulcerative colitis differ because of the characteristically dissimilar behaviors of the intestinal inflammation in these two diseases.
Lymphocytic ColitisMicroscopic colitis (lymphocytic colitis and collagenous colitis) is a disease of inflammation of the colon. Microscopic colitis is only visible when the colon's lining is examined under a microscope. The cause of microscopic colitis is not known. Symptoms of microscopic colitis are chronic watery diarrhea and abdominal pain or cramps. Microscopic colitis is diagnosed through biopsies of several areas of the colon. There is no standardized treatment for microscopic colitis; however, eliminating NSAIDs, and treatment medications such as Imodium, Lomotil, Petpo-Bismol, Entocort EC, and mesalamine (Asacol) have been helpful in some individuals.
Ulcerative ColitisUlcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Ulcerative colitis is closely related to Crohn's disease, and together they are referred to as inflammatory bowel disease. Treatment depends upon the type of ulcerative colitis diagnosed.