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- What is meloxicam, and how does it work (mechanism of action)?
- What are the uses for meloxicam?
- What are the side effects of meloxicam?
- What is the dosage for meloxicam?
- Which drugs or supplements interact with meloxicam?
- Is meloxicam safe to take if I'm pregnant or breastfeeding?
- What else should I know about meloxicam?
What is meloxicam, and how does it work (mechanism of action)?
Meloxicam is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) that are used to treat pain and/or inflammation. Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. Prostaglandins are chemicals that contribute to inflammation especially within joints, and it is the inflammation that leads to the common symptoms of pain, tenderness, and swelling associated with arthritis. Meloxicam blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and reduces the levels of prostaglandins. As a result, inflammation and its accompanying symptoms are reduced. Meloxicam was approved for use in April 2000.
What are the uses for meloxicam?
What are the side effects of meloxicam?
- Individuals who are allergic to NSAIDs may experience shortness of breath when given an NSAID. People with asthma also are at a higher risk for experiencing serious allergic reaction to NSAIDs. Individuals with a serious allergy to one NSAID are likely to experience a similar reaction to a different NSAID.
- New onset or worsening of high blood pressure (hypertension) may occur. Blood pressure should be monitored closely during treatment.
- Meloxicam may cause fluid retention and swelling (edema). It should be used cautiously in people with heart failure.
- Meloxicam may reduce kidney function. Therefore, it should not be used in people with severe kidney failure. It should be used cautiously in the elderly, people with heart failure, liver dysfunction, and those taking diuretics, ACE-inhibitors, or angiotensin II antagonists.
- Serious skin reactions such as exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis (TEN) may occur without warning.
- NSAIDs (except low dose aspirin) may increase the risk of potentially fatal heart attacks, stroke, and related conditions in people with or without heart disease or risk factors for heart disease. The increased risk of heart attack or stroke may occur as early as the first week of use and the risk may increase with longer use and is higher in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.
- Central nervous system effects including drowsiness, dizziness, and blurred vision may occur in patients who are taking an NSAIDs.
Quick GuideRheumatoid Arthritis (RA) Symptoms & Treatment
What is the dosage for meloxicam?
The lowest effective dose should be used for each patient. Meloxicam therapy usually is started at 7.5 mg daily. Some patients require a dose of 15 mg daily, but this larger dose should be taken only under the direction of a physician. Juvenile rheumatoid arthritis is treated with 0.125 mg/kg daily up to 7.5 mg per day. Meloxicam may be taken with or without food.
Which drugs or supplements interact with meloxicam?
Meloxicam may reduce the blood pressure-lowering effects of drugs given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
When meloxicam is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
Individuals taking oral blood thinners, for example, warfarin (Coumadin), should avoid meloxicam because meloxicam also thins the blood, and excessive blood thinning may lead to bleeding.
Meloxicam should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. If aspirin is taken with meloxicam there may be an increased risk for developing a gastrointestinal ulcer.
Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking meloxicam or other NSAIDs.
Meloxicam oral suspension contains sorbitol. Combining sodium polystyrene sulfonate (Kayexalate) with sorbitol may cause fatal intestinal necrosis. Therefore, meloxicam oral solution should not be combined with Kayexalate.
Is meloxicam safe to take if I'm pregnant or breastfeeding?
There have been no studies of meloxicam therapy in pregnant women.. Meloxicam generally should be avoided during the first and second trimester of pregnancy. Because meloxicam may cause a fetal birth defect called ductus arteriosus (early closure of two major blood vessels of the heart and lung) in the third trimester of pregnancy, meloxicam also should be avoided during this last part of pregnancy.
There have been no studies in humans to determine if meloxicam is excreted in breast milk.
What else should I know about meloxicam?
What preparations of meloxicam are available?
Tablets: 7.5, 15 mg. Oral Suspension: 7.5 mg/ml
How should I keep meloxicam stored?
Meloxicam should be stored in a dry place at room temperature, 15 C to 30 C (59 F to 86 F).
Meloxicam (Mobic) is a NASAID prescribed for the treatment of swelling, tenderness, and pain caused by the inflammation of arthritis conditions such as osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis in persons over two years of age. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.
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Medications & Supplements
- sulindac, Clinoril
- oxaprozin, Daypro
- etodolac, Lodine (Discontinued)
- ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, and others)
- fenoprofen, Nalfon
- naproxen (Aleve, Anaprox, Naprelan, Naprosyn)
- ketoprofen (Discontinued brands: Nexcede, Orudis, Oruvail, Actron)
- diclofenac, Voltaren, Cataflam, Voltaren-XR, Cambia
- bromfenac, Duract
- diclofenac and misoprostol, Arthrotec
- celecoxib (Celebrex)
- OTC Pain Relievers and Fever Reducers
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- Drug Interactions
- valdecoxib, Bextra
- Ibuprofen vs. Meloxicam (Mobic) for Pain
Prevention & Wellness
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top meloxicam Related Articles
Bladder InfectionBladder infection is an infection of the bladder, usually caused by bacteria or, rarely, by Candida. Certain people, including females, the elderly, men with enlarged prostates, and those with chronic medical conditions are at increased risk for bladder infection. Bladder infections are treated with antibiotics, but cranberry products and adequate hydration may help prevent bladder infections.
Chronic PainChronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
diclofenacDiclofenac (Voltaren, Cataflam, Voltaren-XR, Cambia) is a nonsteroidal anti-inflammatory medication prescribed to treat inflammation and pain caused by conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and menstrual cramps. Side effects, drug interactions, dosage, and pregnancy safety should be reviewed prior to taking this medication.
etodolacEtodolac (Lodine ([Discontinued]) is a NSAID prescribed to treat pain and inflammation associated with osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, tendinitis, bursitis, and menstrual cramps. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking this medication.
fenoprofenFenoprofen (Nalfon) is a nonsteroidal antiinflammatory drug (NSAID) used for the treatment of pain and inflammation due to osteoarthritis and rheumatoid arthritis. Fenoprofen (Nalfon) is also used for the treatment of mild to moderate pain for conditions such as menstrual cramps, tendinitis, and bursitis. Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce mild to moderate pain, inflammation, and fever. Ibuprofen works by blocking an enzyme that makes prostaglandin (a hormone-like substance that participates in a variety of body functions), which results in lower levels of prostaglandins in the body. Lower levels of prostaglandins reduce pain, inflammation, and fever.
Ibuprofen is prescribed to treat diseases and conditions that cause mild to moderate pain, fever, and inflammation. For example, Pain from strains and sprains; pain from cuts, scrapes, and puncture wounds; muscle aches and pains; tooth pain; common cold; mild headache; some arthritis conditions; joint pain; and to reduce fever.
Common side effects of ibuprofen include, diarrhea, constipation, nausea, heartburn, belly pain, drowsiness, headaches, tinnitus (ringing in the ears), and mild rash.
More serious side effects and adverse effects include, increased bleeding after injury, stomach ulcers, impaired kidney function, severe allergic reaction (anaphylaxis), blood clots, heart attack, heart failure, and high blood pressure.
The maximum dose prescribed under a doctor's care is 3.2 g daily. Otherwise, the over-the-counter (OTC) maximum daily dose is 1.2 g daily. Dosage depends upon the age, weight, and any current medical conditions of the patient. Several drugs interact with ibuprofen so check with your doctor, pharmacist, or other health care professional with questions in regard to this drug. Doctors don't know if it is safe to take ibuprofen if your are pregnant, therefore it is not recommended if you are pregnant. According to the American Academy of Pediatrics, ibuprofen is safe to take while breastfeeding.
REFERENCE: FDA Prescribing Information.
Juvenile ArthritisJuvenile idiopathic arthritis (juvenile rheumatoid arthritis or JRA) annually affects one child in every thousand. There are six types of JIA. Treatment of juvenile arthritis depends upon the type the child has and should focus on treating the symptoms that manifest.
Juvenile Bone HealthSetting a good example for your children when it comes to diet and exercise will help them to make healthy decisions about nutrition and fitness. Eating calcium-rich foods and performing weight-bearing exercise will help your children prevent osteoporosis and fractures later in life.
ketoprofenKetoprofen (Nexcede, Orudis, Oruvail, Actron brands have been discontinued) is a NSAID prescribed to treat inflammation and pain caused by menstrual cramps, types of arthritis like rheumatoid arthritis and osteoarthritis, and other causes of mild to moderate pain. Side effects, drug interactions, storage, dosing, and breastfeeding and pregnancy safety information should be reviewed prior to taking any medication.
naproxenNaproxen (Aleve, Anaprox, Naprelan, Naprosyn) is in the class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen is prescribed for the treatment of mild to moderate pain, inflammation, and fever. Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication.
OsteoarthritisOsteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis. Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
OA of the Knee ExercisesLearn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and surrounding muscles through this picture slideshow.
Osteoarthritis SlideshowOsteoarthritis (OA) is a degenerative joint disease affecting both cartilage and bone. Joints most often affected by osteoarthritis include the knees, hands, back, or hips. Osteoarthritis symptoms include pain, swelling and joint inflammation.
Osteoarthritis PictureOsteoarthritis is a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints. See a picture of Osteoarthritis and learn more about the health topic.
oxaprozinOxaprozin (Daypro) is a drug in the class of nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed for the treatment of the pain and inflammation, welling and tenderness of joints, and fever caused by rheumatoid arthritis and osteoarthritis. Side effects, warnings and precautions, drug interactions, and safety during pregnancy should be reviewed prior to taking this medication.
Pain ManagementPain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include:
- complex regional pain syndrome,
- interstitial cystitis,
- and irritable bowel syndrome.
Rheumatoid ArthritisRheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease.
RA Friendly ExercisesRegular exercise boosts fitness and helps reverse joint stiffness for people with rheumatoid arthritis (RA). Our experts offer helpful exercises to get you started.
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Take the RA QuizHow is rheumatoid arthritis different from other forms of arthritis, such as osteoarthritis and gout? Take the Rheumatoid Arthritis (RA) Quiz to rest your RA IQ.
sulindacSulindac (Clinoril) is a nonsteroidal antiinflammatory drug (NSAID) used for the treatment of pain, fever, swelling, inflammation, and tenderness in the joints caused by rheumatoid arthritis, tendinitis, bursitis, ankylosing spondylitis, gout, osteoarthritis. Side effects, warnings and precautions, drug interactions, and safety during pregnancy should be reviewed prior to taking this medication.