Mebendazole is a member of the benzimidazole class of antiparasitic agents, which also includes thiabendazole, albendazole, and triclabendazole. Mebendazole, like other benzimidazoles, causes death of parasites by interfering with the function of tubulin, an important protein in parasites, and preventing glucose uptake. Mebendazole is active against tapeworms, roundworms, hookworms, threadworms, pinworms, pork worms, and whipworms. The FDA approved mebendazole in June 1974.

GENERIC AVAILABLE: Yes

Yes

Mebendazole may cause:

• abdominal pain
• diarrhea.
• dizziness,
• drowsiness,
• headache,
• vomiting,
• chills,
• itching,
• flushing,
• hiccups,
• ringing in the ears,
• low blood pressure,
• bloody urine, and
• a drop in number of blood cells.

Recommendations are based on the infecting organism being treated.

• Initial dosing for some hookworm, roundworm, tapeworm, and whipworm infections is 100 mg twice daily for 3 days.
• Initial dosing for pinworm infection is 100 mg as a single dose. The dose may be repeated in 2 to 3 weeks if needed.

• Mebendazole should not be used with metronidazole (Flagyl) due to the increased risk of rare but serious life-threatening skin conditions known as Stevens-Johnson syndrome and toxic epidermal necrolysis.
• Carbamazepine (Tegretol, Tegretol SR, Equetro, Carbatrol), fosphenytoin (Cerebyx), ethotoin (Peganone), and phenytoin (Dilantin, Dilantin-125) may interfere with successful treatment with mebendazole by decreasing its blood levels.
• Cimetidine (Tagamet) may increase mebendazole levels and increase the risk of side effects from mebendazole.

Adverse outcomes in animal studies have been observed. Adverse outcomes in human pregnancy have not been seen, however the Centers for Disease Control recommends postponing pinworm therapy until the third trimester when possible.

NURSING MOTHERS: While excretion into breast milk is unlikely, caution should be used since data is not available on excretion of mebendazole into breast milk.

What preparations of mebendazole chewable-oral are available?

Chewable tablets: 100 mg

How should I keep mebendazole chewable-oral stored?

Mebendazole should be protected from light and stored at room temperature, between 15 C to 30 C (59 F to 86 F).