How Does Mixed Connective Tissue Disease (MCTD) Affect Pregnancy?

  • Medical Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Ask the experts

I would like information on MCTD effects with pregnancy.

Doctor's response

Some patients with MCTD (Mixed Connective Tissue Disease) can have difficulty becoming pregnant (decreased fertility). There is also some increased risk of miscarriage in pregnant women with MCTD. Pregnant women with MCTD can have worsening (increased activity) of their disease during pregnancy. I am unaware of any reports of birth defects or other direct effects on the baby of mothers with MCTD.

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Reviewed on 1/11/2018
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