maraviroc (Selzentry)
Type of Drug: Chemokine Coreceptor Antagonist
To infect a cell, HIV must bind to two types of molecules on the cell's surface.
One of these is called a chemokine coreceptor. Drugs known as chemokine coreceptor antagonists block the virus from binding to the molecules.
Note: Because the drug level of Selzentry in your body is affected by many medications, the recommended dosage of Selzentry depends on what other medications you are taking. It is important to discuss this with your medical provider before you start taking Selzentry or any other medication.
Approved adult dosing
one 300 mg tablet, two times a day (standard dosage)
- Morning
Selzentry 300 mg
- Evening
Selzentry 300 mg
Note: Other HIV medications compatible with this dosage: Aptivus, AZT, Emtriva, Epivir, Fuzeon, Videx-EC, Viramune, Viread, Zerit, Ziagen; consult your medical provider
one 150 mg tablet, two times a day
- Morning
Selzentry 150 mg
- Evening
Selzentry 150 mg
Note: This dose recommended if Selzentry is used in a regimen that contains Crixivan, Invirase, Lexiva, Norvir, Prezista, Reyataz, Viracept, or Rescriptor; consult your medical provider
two 300 mg tablets, two times a day
- Morning
Selzentry 300 mg
- Evening
Selzentry 300 mg
Note: This dose recommended if Selzentry is used in a regimen that contains Sustiva or etravirine (an experimental drug) without Crixivan, Invirase, Lexiva, Norvir, Prezista, Reyataz, or Viracept; consult your medical provider
Notes on taking this medication
- Many medications used to treat HIV-related illnesses and other conditions interact with Selzentry. Persons using Selzentry with these medications may need an adjustment to their dosage of Selzentry; consult your medical provider
- Selzentry only works against HIV that binds to a molecule called CCR5 (this type of HIV is sometimes referred to as "R5 virus"). Before you start taking Selzentry, you must have a special blood test (called a tropism assay) to determine whether you have R5 virus or another type of HIV
- The FDA has approved Selzentry for use only by persons whose HIV is resistant to many other HIV medications
Side effects
- Cough; upper respiratory tract infections
- Muscle and joint pain
- Diarrhea
- Sleep disturbance
QUESTION
What is HIV? See AnswerSummary
Maraviroc (Selzentry) is a chemokine coreceptor antagonist drug prescribed for the treatment of human immunodeficiency virus (HIV). Side effects, drug interactions, warnings and precautions, and patient information should be reviewed prior to taking any medication.
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Human Immunodeficiency Virus (HIV)
HIV (human immunodeficiency virus) infection left untreated causes AIDS (acquired immunodeficiency syndrome). The human immunodeficiency virus (HIV) is a type of virus called a retrovirus, which can infect humans when it comes in contact with tissues that line the vagina, anal area, mouth, or eyes, or through a break in the skin. HIV infection is generally a slowly progressive disease in which the virus is present throughout the body at all stages of the disease. Three stages of HIV infection have been described. The initial stage of infection (primary infection), which occurs within weeks of acquiring the virus, often is characterized by the flu- or mono-like illness that generally resolves within weeks. The stage of chronic asymptomatic infection (meaning a long duration of infection without symptoms) lasts an average of eight to 10 years without treatment. The stage of symptomatic infection, in which the body's immune (or defense) system has been suppressed and complications have developed, is called the acquired immunodeficiency syndrome (AIDS). The symptoms are caused by the complications of AIDS, which include one or more unusual infections or cancers, severe loss of weight, and intellectual deterioration (called dementia). When HIV grows (that is, by reproducing itself), it acquires the ability to change (mutate) its own structure. These mutations enable the virus to become resistant to previously effective drug therapy. The goals of drug therapy are to prevent damage to the immune system by the HIV virus and to halt or delay the progress of the infection to symptomatic disease. Therapy for HIV includes combinations of drugs that decrease the growth of the virus to such an extent that the treatment prevents or markedly delays the development of viral resistance to the drugs. The best combination of drugs for HIV are those that effectively suppress viral replication in the blood and also are well tolerated and simple to take so that people can take the medications consistently without missing doses.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
<http://www.hiv.va.gov/vahiv?page=treat-drug-Selzentry>