MAOIs (Monoamine Oxidase Inhibitors) Side Effects

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

What are monoamine oxidase inhibitors (MAOIs)? How do they work (mechanism of action)?

MAOIs were the first class of antidepressants to be developed. They fell out of favor because of concerns about interactions with certain foods and numerous drug interactions. MAOIs elevate the levels of norepinephrine, serotonin, and dopamine by inhibiting an enzyme called monoamine oxidase. Monoamine oxidase breaks down norepinephrine, serotonin, and dopamine. When monoamine oxidase is inhibited, norepinephrine, serotonin, and dopamine are not broken down, increasing the concentration of all three neurotransmitters in the brain.

MAOIs also are used for the treatment of Parkinson's disease.

What are the side effects of MAOIs?

Since MAOIs work in the brain and affect neurotransmitters, they have many side effects. Side effects of MAOIs are:

MAOIs also carry boxed warnings of suicidal thinking and suicidal behavior in children, adolescents, and young adults.

What drugs interact with MAOIs?

MAO inhibitors should be avoided with other antidepressants such as paroxetine fluoxetine, amitriptyline, nortriptyline, bupropion; pain medications like methadone, tramadol, and meperidine; dextromethorphan, St. Johns Wort, cyclobenzaprine, and mirtazapine. Such combinations lead to high serotonin levels which may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death. These medications should not be used within 14 days of stopping an MAOI.

MAOIs also interact with seizure medications like carbamazepine (Tegretol Tegretol XR, Equetro, Carbatrol)and oxcarbazepine (Trileptal) through unknown mechanisms, increasing side effects.

MAOIs are not recommended for use with medications like pseudoephedrine, phenylephrine, ephedrine, and phenylpropanolamine. The combination of MAO inhibitors and these drugs can cause an acute hypertensive episode.

Monoamine oxidase also breaks down tyramine, a chemical present in aged cheese, wines, and other aged foods. Since MAOIs inhibit monoamine oxidase, they decrease the breakdown of tyramine from ingested food, thus increasing the level of tyramine in the body. Excessive tyramine can elevate blood pressure and cause a hypertensive crisis. Patients treated with MAOIs should adhere to recommended dietary modifications that reduce the intake of tyramine.

5 examples of MAOI depression medications

Examples of oral MAOIs include:

  1. rasagiline (Azilect),
  2. selegiline (Eldepryl, Zelapar),
  3. isocarboxazid (Marplan),
  4. phenelzine (Nardil), and
  5. tranylcypromine (Parnate).

Selegiline is also available in a topical patch form called Emsam.

Are MAOIs safe to take if I'm pregnant or breastfeeding?

  • The FDA classifies MAO inhibitors in pregnancy category C, which means that there is no established evidence of safe and effective use of MAO inhibitor in pregnant women. Therefore, infant risk cannot be ruled out.
  • It is not known whether MAO inhibitors enter breast milk; however, MAO inhibitors should be avoided in nursing mothers to avoid harm to the fetus.

Summary

Monoamine oxidase inhibitors (MAOIs, MAOI) is a class of antidepressants. They are infrequently prescribed because of concerns about interactions with particular foods and several drug interactions. Side effects, drug interactions, storage, dosage, and pregnancy safety information should be reviewed prior to taking any medication.

Treatment & Diagnosis

Prevention & Wellness

Health Solutions From Our Sponsors

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 9/14/2018
References
REFERENCE: Garcia, E, MD. et al. Monoamine Oxidase Inhibitor Toxicity. Medscape. Updated: Jul 21, 2017.
<https://emedicine.medscape.com/article/815695-overview>
CONTINUE SCROLLING FOR RELATED SLIDESHOW