- Diabetic Peripheral Neuropathy Slideshow
- Diabetes and Foot Problems Slideshow
- Diabetic Neuropathy Quiz: Test Your Medical IQ
- Lyrica (pregablin) vs. gabapentin (Neurontin) quick comparison
- What is Lyrica? What is gabapentin? How do they work?
- What are the uses for Lyrica vs. gabapentin?
- What are the side effects of Lyrica vs. gabapentin?
- Is gabapentin addictive? Is it a narcotic?
- What is the dosage of Lyrica vs. gabapentin?
- What drugs interact with Lyrica vs. gabapentin?
- Are Lyrica or gabapentin safe to take if I am pregnant or breastfeeding?
Lyrica (pregablin) vs. gabapentin (Neurontin) quick comparison
- Lyrica (pregablin) and gabapentin (Neurontin) are anti-epileptic medications used to treat seizures and nerve pain (neuropathic pain).
- Gabapentin also is used to treat nerve pain caused by shingles (herpes zoster).
- Other uses for Lyrica are neuropathic (nerve) pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and fibromyalgia.
- Side effects of gabapentin and that are similar include:
- Side effects of gabapentin that are different from Lyrica include:
- Difficulty speaking
- Viral infections
- Unusual eye movements
- Jerky movements
- Side effects of Lyrica that are different from gabapentin include:
- Both gabapentin and Lyrica may interact with alcohol and drugs that cause sedation including narcotic pain medications. Gabapentin also may interact with nonsteroidal anti-inflammatory drugs (NSAIDs).
- Neurontin, Gralise, Horizant, Fanatrex, and FusePag) are the brand names available for gabapentin in the US. Pregabalin is the generic name for the brand name Lyrica.
What is Lyrica? What is gabapentin? How do they work?
Gabapentin is an anti-seizure (anti-convulsant) drug that is used for preventing seizures and for treating post-herpetic neuralgia, the pain that follows an episode of shingles. Doctors do not know how gabapentin works. Gabapentin structurally resembles the neurotransmitter gamma aminobutyric acid (GABA). It is possible that this similarity is related to gabapentin's mechanism of action. In animal models used for testing the anticonvulsant and analgesic (anti-pain) activities of drugs, gabapentin prevents seizures and reduces pain-related responses.
Lyrica (pregabalin) is an oral medication that is chemically related to gabapentin (Gralise, Neurontin). It is used for treating pain caused by neurologic diseases such as postherpetic neuralgia as well as seizures. It also is used for treating fibromyalgia.
What are the uses for Lyrica vs. gabapentin?
Lyrica is used for:
- Neuropathic pain associated with diabetic peripheral neuropathy or postherpetic neuralgia
- Spinal cord injury
- In combination with other drugs to treat partial onset seizures in adults
- Treating fibromyalgia
There are many non FDA-approved uses for gabapentin. These include:
What are the side effects of Lyrica vs. gabapentin?
Lyrica side effects
SIDE EFFECTS WARNING: Antiepileptic medications have been associated with increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
The most common side effects of Lyrica include:
- dry mouth (xerostomia),
- edema (accumulation of fluid),
- blurred vision,
- double vision (diplopia),
- weight gain,
- fatigue (tiredness),
- abnormal gait (ataxia),
- tremor, and
- difficulty concentrating.
Other side effects include
- increased appetite,
- myoclonus (sudden, involuntary jerking of a muscle or muscle groups),
- heart failure,
- low blood pressure,
- reduced blood platelet counts, and
- increased blood creatinine kinase levels.
Increased creatinine kinase can be a sign of muscle injury, and in clinical trials three patients experienced rhabdomyolysis (severe muscle injury). Therefore, patients should report unexplained muscle pain, tenderness or weakness to their doctors, especially if associated with fever and malaise (reduced well-being). Lyrica has rarely been associated with angioedema (swelling of the face, tongue, lips, and gums, throat and larynx).
Gabapentin side effects
The most common side effects of gabapentin are:
- Fluid retention (edema)
- Difficulty speaking
- Jerky movements
- Unusual eye movements
- Double vision
- Memory loss
Other adverse effects and serious side effects associated with gabapentin include:
Antiepileptic medications have been associated with an increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
Is gabapentin addictive? Is it a narcotic?
Gabapentin is not an opioid narcotic, and it is not classified as a controlled substance by the Drug Enforcement Agency (DEA). However, this medication does share signs and symptoms associated with drug misuse, addiction, and withdrawal symptoms of opioids like:
What is the dosage of Lyrica vs. gabapentin?
Lyrica dosage instructions
- Lyrica may be taken with or without food.
- Treating diabetic peripheral neuropathy: The initial dose for neuropathic pain associated with diabetic peripheral neuropathy is 50 mg three times a day (150 mg/day). The dose may be increased to a maximum dose of 100 mg 3 times daily (300 mg/day) after one week.
- Treating postherpetic neuralgia: The recommended dose for postherpetic neuralgia is 75-150 mg twice daily or 50-100 mg three times daily. Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day). The dose may be increased to 100 mg 3 times daily (300 mg/day) after one week. If pain relief is inadequate after 2-4 weeks of treatment at 300 mg/day, the dose may be increased to 300 mg twice daily or 200 mg three times daily. Doses greater than 300 mg cause more side effects.
- Treating neuropathic pain associated with spinal cord injury: The dose for treating neuropathic pain associated with spinal cord injury is 150 to 600 mg daily. Begin dosing at 75 mg two times a day an increase to 150 mg two times daily after one week if response is inadequate. May increase to 300 mg twice daily if response is inadequate after 2 to 3 weeks.
- Treating seizures: The recommended dose for treating seizures is 150-600 mg/day divided into 2 or 3 doses, starting at 150 mg daily and increasing based on response and tolerability. The maximum dose is 600 mg/day.
- Treating fibromyalgia: Fibromyalgia is treated with 300-450 mg/day in 2 or 3 divided doses.
Gabapentin dosage instructions
- Gabapentin may be taken with or without food.
- Treating postherpetic neuralgia: The recommended dose for postherpetic neuralgia is 1800 mg daily in 3 divided doses (Neurontin) or 1800 mg once daily (Gralise). Gralise is not interchangeable with other gabapentin products.
- Treating seizures: Seizures are treated with 900-1800 mg/daily in 3 divided doses (Neurontin). Withdrawal of treatment should occur slowly over a week.
What drugs interact with Lyrica vs. gabapentin?
Lyrica drug interactions
- Alcohol and drugs that cause sedation may increase the sedative effects of pregabalin.
- Pioglitazone (Actos) and rosiglitazone (Avandia) cause weight gain, fluid retention, and possibly heart failure. Therefore, combining pregabalin with these drugs may increase the occurrence of weight gain and fluid retention.
Gabapentin drug interactions
- Antacids reduce the concentration of gabapentin in blood. Therefore, gabapentin should be administered 2 hours or more after taking antacids.
- Morphine significantly increases blood concentrations of gabapentin and may increase central nervous system-related adverse events associated with gabapentin.
Are Lyrica or gabapentin safe to take if I am pregnant or breastfeeding?
- There are no adequate studies of Lyrica in pregnant women.
- It is not known whether Lyrica is excreted in breast milk.
- Doctors do not know the safety of gabapentin during pregnancy.
- Gabapentin is secreted in human breast milk; therefore, if you are pregnant you should only use this medication if the benefits outweigh the unknown risk to the fetus.
Latest Diabetes News
Daily Health News
Lyrica (pregablin) and gabapentin (Neurotin) are drugs used to prevent seizures and to treat nerve pain associated with various conditions, for example, shingles. Lyrica and gabapentin are chemically related, but researchers do not know exactly how they work. Gabapentin also has several off-label uses to treat other conditions that cause pain, and substance abuse withdrawal.
Both pain medications also treat fibromyalgia. Off-label uses (non-FDA approved) for gabapentin are hot flashes, hiccups, restless leg syndrome (RLS), hyperhidrosis (excessive sweating), headaches, and diabetic neuropathy. Lyrica also treats pain associated with spinal cord injuries.
Side effects of Lyrica that are different from gabapentin include constipation, weight gain, dry mouth, constipation, breast enlargement, and edema (swelling). Side effects unique to gabapentin include viral infections, fever, speech problems, unusual eye movements, and jerky movements.
The generic name for Lyrica is pregabalin. Gabapentin is available in the US under the brand names Neurontin, Gralise, Horizant, Fanatrex, and FusePag.
Multimedia: Slideshows, Images & Quizzes
Restless Leg Syndrome (RLS) Quiz: Test Your Medical IQ
Restless leg syndrome (RLS), an annoying, sometimes painful disorder that keeps millions of people awake at night. What are the...
Epilepsy & Seizures Quiz: What Causes Seizures?
Do you know the difference between seizures and epilepsy? What are the types of seizures? Take the Epilepsy & Seizures Quiz to...
Headaches Quiz: Learn About Headache Pain
If you're plagued with headaches, our Headaches Quiz may help you identify causes, triggers, symptoms, and treatments for...
Fibromyalgia Quiz: What Is Fibromyalgia?
Fibromyalgia could be the reason for your constant, deep bodily pain. Learn more about this painful condition with the...
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Picture of Hyperhidrosis: Starch-Iodine Test
Hyperhidrosis, or excessive sweating, is a common disorder that produces a lot of unhappiness. An estimated 2%-3% of Americans...
Picture of Fibromyalgia
A syndrome characterized by chronic pain, stiffness, and tenderness of muscles, tendons, and joints without detectable...
Fibromyalgia Symptoms, Diagnosis & Treatment
What is fibromyalgia? Fibromyalgia is a chronic condition that causes pain and stiffness of the tendons, muscles, and joints....
Fibromyalgia Pain Relief With Stretching and Strength Exercises in Pictures
Living with fibromyalgia is painful. By making simple exercise modifications, you can boost your energy, decrease pain and...
Nerve Pain: Symptoms, Causes, and Treatment Options
Learn about nerve pain symptoms, causes, and treatment options. Discover medications, treatments, and natural remedies that can...
Migraine or Headache? Migraine Symptoms, Triggers, Treatment
What does a migraine feel like? Discover the difference between headaches and migraines. Learn to spot migraine symptoms early,...
Alcohol Abuse: 12 Health Risks of Chronic Heavy Drinking
Read about the health risks of chronic heavy or binge drinking. Anemia, cancer, gout, cardiovascular disease and many more...
Fibromyalgia Treatments and Tips to Ease Pain and Other Symptoms
What is fibromyalgia? Learn about fibromyalgia symptoms such as trigger points (also called tender points), learn what causes...
What Causes You to Sweat? Hidrosis and Hyperhidrosis
What makes you sweat (hidrosis)? Excessive sweating (hyperhidrosis) has many potential causes, including spicy food, smoking,...
Migraine Headaches: 14 Non-Drug Treatments for Migraines
Learn about 14 non-drug treatments for migraines. Acupuncture, biofeedback and massage therapy are among this list of non-drug...
Diabetic Peripheral Neuropathy: Improve Diabetes Nerve Pain
Read about diabetic peripheral neuropathy and exercises to manage nerve pain. Learn how to cope with the symptoms of diabetic...
Restless Legs Syndrome: 16 Natural Remedies and Treatment for RLS
Restless legs syndrome treatment includes natural remedies that you can implement at home. Use exercise, sleep hygiene, and...
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive pain management...
Related Disease Conditions
Fibromyalgia is a chronic pain condition characterized by symptoms such as fatigue, sleep disturbances, and tender points. Stress...
Migraine headache is a type of headache associated with a sensitivity to light, smells, or sounds, eye pain, severe pounding on...
Epilepsy is a brain disorder in which the person has seizures. There are two kinds of seizures, focal and generalized. There are...
Restless Leg Syndrome (Symptoms, Causes, Treatment Medications, Home Remedies)
Restless leg syndrome (RLS) is a common cause for painful legs that typically eases with motion, and becomes worse and more...
Alcoholism is a disease that includes alcohol craving and continued drinking despite repeated alcohol-related problems, such as...
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to...
Headaches can be divided into two categories: primary headaches and secondary headaches. Migraine headaches, tension headaches,...
Drug addiction is a chronic disease that causes drug-seeking behavior and drug use despite negative consequences to the user and...
Cocaine and Crack Abuse
Cocaine is an addictive stimulant that is smoked, snorted, and injected. Crack is cocaine that comes in a rock crystal that is...
Excessive Sweating (Hyperhidrosis)
Hyperhidrosis is excessive sweating of the underarms, palms, or soles of the feet. Treatment may involve over-the-counter...
Neuropathic pain is a chronic condition that leads to ongoing pain symptoms. Patients can be predisposed to developing...
Seizures Symptoms and Types
Seizures are divided into two categories: generalized and partial. Generalized seizures are produced by electrical impulses from...
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive...
Hot Flashes (Causes, Symptoms & Medication Treatment in Men and Women)
Hot flashes (or flushing) is the most common symptom experienced by a woman prior to and during the early stages of menopause,...
Hiccups (Causes, Cures, Remedies, and Medicine)
Hiccups are a sudden, involuntary contraction of the diaphragm muscle. In general hiccups are just a temporary condition. Some of...
Pain Management: Neuropathic Pain
Neuropathic pain is chronic pain resulting from injury to the nervous system. The injury can be to the central nervous system...
Occipital Neuralgia (Headache)
Occipital neuralgia is a type of headache that involves inflammation or irritation of occipital nerves. Signs and symptoms...
Seizure vs. Seizure Disorders (Differences and Similarities)
The differences between a seizure, epilepsy, and seizure disorders are confusing to many people. What makes it more confusing, is...
Migraine vs. Headache: Differences and Similarities
Headaches are the most common reason why a person goes to the doctor or other healthcare professional for treatment. There are...
Rheumatoid Arthritis vs. Fibromyalgia
Though rheumatoid arthritis (RA) and fibromyalgia have similar symptoms, RA is an autoimmune disease and fibromyalgia is a...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.