- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What's the difference between Lyrica (pregabalin) vs. Klonopin (clonazepam)?
- What is Lyrica? What is Klonopin?
- What are the side effects of Lyrica and Klonopin?
- What is the dosage of Lyrica vs. Klonopin?
- What drugs interact with Lyrica and Klonopin?
- Are Lyrica and Klonopin safe to use while pregnant or breastfeeding?
What's the difference between Lyrica (pregabalin) vs. Klonopin (clonazepam)?
- Lyrica (pregabalin) and Klonopin (clonazepam) are used to treat and prevent seizures.
- Lyrica is also used to treat neuropathic pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and fibromyalgia.
- Klonopin is also used to treat panic disorder.
- Lyrica and Klonopin belong to different drug classes. Lyrica is an anti-epileptic drug (AED) and Klonopin is a benzodiazepine.
- Side effects of Lyrica and Klonopin that are similar include dizziness, fatigue, amnesia, and confusion or disorientation.
- Side effects of Lyrica that are different from Klonopin include dry mouth, nausea, constipation, drowsiness, fluid retention (edema), blurred vision, double vision, weight gain, abnormal gait, tremor, difficulty concentrating, increased appetite, gas, myoclonus (sudden, involuntary jerking of a muscle or muscle groups), heart failure, low blood pressure, vomiting, reduced blood platelet counts, and increased blood creatinine kinase levels.
- Side effects of Klonopin that are different from Lyrica include sedation, depression, headache, weakness, unsteadiness, sleep disturbance, lack of inhibition, changes in sexual desire, rash, and irritability.
- Withdrawal symptoms may occur if you suddenly stop taking Klonopin.
What is Lyrica? What is Klonopin?
Lyrica (pregabalin) is an oral medication chemically related to gabapentin (Gralise, Neurontin) used to treat pain caused by neurologic diseases such as postherpetic neuralgia as well as seizures. It also is used to treat fibromyalgia.
Klonopin (clonazepam) is a benzodiazepine type anti-anxiety medication primarily used for treating panic disorder and preventing certain types of seizures. Other benzodiazepines include diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), and flurazepam (Dalmane). Benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits brain activity. It is believed that excessive activity in the brain may lead to anxiety or other psychiatric disorders.
What are the side effects of Lyrica and Klonopin?
Antiepileptic medications have been associated with increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
The most common side effects of Lyrica are
- dry mouth (xerostomia),
- edema (accumulation of fluid),
- blurred vision,
- double vision (diplopia),
- weight gain,
- fatigue (tiredness),
- abnormal gait (ataxia),
- tremor, and
- difficulty concentrating.
Other side effects include
- increased appetite,
- myoclonus (sudden, involuntary jerking of a muscle or muscle groups),
- heart failure,
- low blood pressure,
- reduced blood platelet counts, and
- increased blood creatinine kinase levels.
Increased creatinine kinase can be a sign of muscle injury, and in clinical trials three patients experienced rhabdomyolysis (severe muscle injury). Therefore, patients should report unexplained muscle pain, tenderness or weakness to their doctors, especially if associated with fever and malaise (reduced well-being). Lyrica has rarely been associated with angioedema (swelling of the face, tongue, lips, and gums, throat and larynx).
The most common side effects associated with clonazepam are sedation, which is reported in approximately half of patients. Dizziness is reported in one-third of patients.
Other common side effects include:
- A feeling of depression,
- Loss of orientation,
- Unsteadiness, and
- Sleep disturbance
- Lack of inhibition
- Changes in sexual desire
Other serious side effects of clonazepam include:
- Respiratory depression
- Enlarged liver
- Withdrawal symptoms (if stopped suddenly)
- Increased heart rate
- Low blood pressure
- Blood disorders
Other serious adverse reactions:
Antiepileptic medications have been associated with an increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need for the antiepileptic drug. Patients who begin antiepileptic therapy should be closely observed for clinical worsening, suicidal thoughts or unusual changes in behavior.
What is the dosage of Lyrica vs. Klonopin?
- Lyrica may be taken with or without food.
- Treating diabetic peripheral neuropathy: The initial dose for neuropathic pain associated with diabetic peripheral neuropathy is 50 mg three times a day (150 mg/day). The dose may be increased to a maximum dose of 100 mg 3 times daily (300 mg/day) after one week.
- Treating postherpetic neuralgia: The recommended dose for postherpetic neuralgia is 75-150 mg twice daily or 50-100 mg three times daily. Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day). The dose may be increased to 100 mg 3 times daily (300 mg/day) after one week. If pain relief is inadequate after 2-4 weeks of treatment at 300 mg/day, the dose may be increased to 300 mg twice daily or 200 mg three times daily. Doses greater than 300 mg cause more side effects.
- Treating neuropathic pain associated with spinal cord injury: The dose for treating neuropathic pain associated with spinal cord injury is 150 to 600 mg daily. Begin dosing at 75 mg two times a day an increase to 150 mg two times daily after one week if response is inadequate. May increase to 300 mg twice daily if response is inadequate after 2 to 3 weeks.
- Treating seizures: The recommended dose for treating seizures is 150-600 mg/day divided into 2 or 3 doses, starting at 150 mg daily and increasing based on response and tolerability. The maximum dose is 600 mg/day.
- Treating fibromyalgia: Fibromyalgia is treated with 300-450 mg/day in 2 or 3 divided doses.
The dose of clonazepam is tailored to the patient's needs.
- For seizures in adults, the initial dose is 1.5 mg daily in 3 divided doses.
- Dosage may be increased by 0.5 to 1 mg daily every 3 days until seizures are controlled or side effects preclude further increases in dose.
- The maximum dose is 20 mg daily. The initial dose for panic disorders is 0.25 mg twice daily.
- The dose may be increased to the target dose of 1 mg daily after 3 days.
What drugs interact with Lyrica and Klonopin?
Alcohol and recreational drugs that cause sedation may increase the sedative effects of pregabalin.
Pioglitazone (Actos) and rosiglitazone (Avandia) cause weight gain, fluid retention, and possibly heart failure. Therefore, combining pregabalin with these drugs may increase the occurrence of weight gain and fluid retention.
Clonazepam, like all other benzodiazepines, accentuates the effects of other drugs that slow the brain's processes, such as alcohol, barbiturates, and narcotics and leads to increased sedation.
Subscribe to MedicineNet's General Health Newsletter
Are Lyrica and Klonopin safe to use while pregnant or breastfeeding?
- There are no adequate studies of Lyrica in pregnant women.
- It is not known whether Lyrica is excreted in breast milk.
- Clonazepam and other benzodiazepines have been associated with fetal damage, including congenital malformations, when taken by pregnant women in their first trimester. Clonazepam is best avoided in the first trimester and probably throughout pregnancy.
- Benzodiazepines are secreted in breast milk. Mothers who are breastfeeding should not take clonazepam.
Lyrica (pregabalin) and Klonopin (clonazepam) are used to treat and prevent seizures. Lyrica is also used to treat neuropathic pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and fibromyalgia.
Multimedia: Slideshows, Images & Quizzes
Pain Management: All About CBD Oil
Cannabidiol oil: It's made from marijuana and everyone seems to be talking about it. But what is it, and what does it really do?...
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive pain management...
Pain Management: Surprising Causes of Pain
What’s causing your pain? Learn the common causes of lower back pain, as well as pain in the knee, stomach, kidney, shoulder,...
Back Pain Quiz: Test Your Back Pain IQ
There are numerous causes of chronic lower back pain and only one ailment gets more complaints. What is it? Quiz your knowledge...
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Nerve Pain: Symptoms, Causes, and Treatment Options
Learn about nerve pain symptoms, causes, and treatment options. Discover medications, treatments, and natural remedies that can...
Chronic Pain Syndrome: Treatment and Management for CPS
What is chronic pain syndrome (CPS)? See causes, symptoms and treatment options including medications. Learn about pain...
Pain Management: Knee Pain Dos and Don'ts
Your knees go through a lot in the course of a day, and sometimes they can run into trouble. Here are a few things you can do...
Back Pain: Bad Habits for Your Back
You’re more likely to have back pain as you get older. Here’s how to avoid making things worse with bad habits....
Pain Management: Visual Guide to Frozen Shoulder
It's got nothing to do with cold weather. It means your shoulder is jammed up. WebMD guides you through the causes of frozen...
Related Disease Conditions
Pain Management and Rheumatoid Arthritis
Second Source article from WebMD...
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive...
Muscle Pain (Myofascial Pain Syndrome)
Neuropathic pain is a chronic condition that leads to ongoing pain symptoms. Patients can be predisposed to developing...
Pain Management: Musculoskeletal Pain
Natural menopause is the permanent ending of menstruation that is not brought on by any type of medical treatment. For women...
Pain Management: Neuropathic Pain
Neuropathic pain is chronic pain resulting from injury to the nervous system. The injury can be to the central nervous system...
Treatment & Diagnosis
Medications & Supplements
- clonazepam (Klonopin)
- Lyrica (pregabalin)
- Klonopin vs. Ativan
- Lyrica (pregabalin) vs. Xanax (alprazolam)
- Klonopin (clonazepam) vs. Xanax (alprazolam)
- Lyrica (pregabalin) vs. Cymbalta (duloxetine)
- Lyrica (pregabalin) vs. Norco (hydrocodone and acetaminophen)
- Lyrica (pregabalin) vs. Topamax (topiramate)
- Lyrica (pregabalin) vs. Savella (milnacipran)
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information