GENERIC NAME: LYMPHOCYTE IMMUNE GLOBULIN, ANTI-THYMOCYTE GLOBULIN (HORSE) - INJ (LIM-foe-site, AN-ti THIGH-mow-site)
BRAND NAME(S): Atgam
USES: Lymphocyte immune globulin is used with other medications to prevent or treat rejection of a kidney transplant. It is also used to treat a certain blood disorder (aplastic anemia) in patients who cannot have a bone marrow transplant.This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your immune system. For kidney transplants, this effect helps your body to accept the new kidney as if it were your own. For aplastic anemia, this effect helps to slow or stop the damage to the bone marrow caused by the immune system so that the bone marrow can continue to produce red blood cells, white blood cells, and platelets.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used to prevent rejection of other transplants (e.g., skin) or to treat other immune system problems.
HOW TO USE: This medication is given by injection into a vein by a health care professional. Health care professionals must follow all the manufacturer's instructions for properly mixing and giving this drug. If you have any questions about using this medication properly, consult your doctor or pharmacist.Dosage is based on your medical condition, weight, and response to treatment. Your doctor may direct you to take other medications (e.g., acetaminophen, diphenhydramine) before the infusion to help prevent side effects.A skin test is recommended before the first dose of the medication to test if you may be allergic to it. Consult your doctor or pharmacist for details.
SIDE EFFECTS: Nausea, vomiting, diarrhea, mild rash/itching, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: back/chest pain, shortness of breath, dizziness, joint/muscle pain, pain/redness/swelling at the injection site or arms/legs, swelling ankles/feet, mouth sores, unusual weakness/tiredness, unusual movements (e.g., shaking), tingling/numbness of the hands/feet, increased thirst/urination, severe stomach/abdominal pain, mental/mood changes (e.g., confusion), black/bloody stools.Tell your doctor immediately if any of these rare but very serious side effects occur: seizures, fast/slow/irregular heartbeat, change in the amount of urine, yellowing eyes/skin, dark urine.This medication may cause or worsen very serious blood disorders (low number of blood cells such as red cells, white cells, and platelets). This effect can cause anemia, decrease your body's ability to fight an infection, or cause your body to bruise or bleed more easily. Tell your doctor immediately if you develop any of the following symptoms: signs of infection (e.g., fever, chills, persistent sore throat), easy bruising/bleeding, unusual tiredness, fast/pounding heartbeat.Some ingredients in this medication is made from human blood. Even though donors are carefully screened and this medication goes through a special manufacturing process, there is a very small chance that you may get infections from the medication (e.g., viruses). Tell the doctor immediately if you develop any signs of infection, including fever or persistent sore throat.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before receiving this medication, tell your doctor or pharmacist if you are allergic to it or if you have had a severe reaction to it; or to other immune globulins; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood/bone marrow disorders (e.g., leukopenia, thrombocytopenia), recent/current infections.Before having surgery, tell your doctor or dentist that you are using this medication.Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.Wash your hands well to prevent the spread of infections.To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.This medication is not recommended for use during pregnancy. Consult your doctor for more details.It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.
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MISSED DOSE: For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule.
STORAGE: Refrigerate between 36-46 degrees F (2-8 degrees C) away from light. Do not freeze. Refrigerate the diluted medication and use within 24 hours. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.