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What is Lymepak, and how does it work?
Lymepak is a prescription medicine used for the treatment of early Lyme disease due to a bacteria known as Borrelia burgdorferi in adults and children 8 years of age and older weighing 99 pounds (lbs) (45 kg) and above.
It is not known if Lymepak is safe and effective in children less than 8 years of age or weighing under 99 lbs (45 kg).
What are the side effects of Lymepak?
Lymepak may cause serious side effects, including:
- Harm to an unborn baby.
- Harm to infants and children under 8 years of age:
- Diarrhea. Diarrhea can happen with most antibiotics, including Lymepak. This diarrhea may be caused by an infection (Clostridium Difficile) in your intestines. Call your doctor right away if you get watery or bloody stools, this can happen anytime while on Lymepak, or even two or more months after taking your last dose.
- Severe Skin Reactions Stop taking
Lymepak and tell your doctor right away if you get any of the following symptoms during treatment with
- rash with red, purple, blue or gray discoloration with fever
- trouble breathing
- feeling uneasy
- itching or burning eyes
- sensitivity to light
- joint pain
- painful skin with blisters
- skin peeling (chest, face, palms of the hands or soles of the feet)
- sores or ulcers (mouth, eyes, vagina or penis)
- swollen lymph nodes
- Jarisch-Herxheimer Reaction. This reaction can happen in people with early Lyme Disease and begins one to two hours after the first dose of Lymepak and disappears within 12 to 24 hours. The reaction may include fever, chills, muscle pain, headache, worsening of skin lesions, fast heart rate, fast breathing, flushing of skin, and increase in blood pressure. Tell your doctor if you have any of these symptoms.
- Increased pressure around the brain (intracranial hypertension). This condition may lead to vision changes and permanent vision loss. You may be more likely to get intracranial hypertension if you are female of childbearing age and are overweight or have a history of intracranial hypertension. Stop taking Lymepak and call your doctor right away if you have blurred or double vision, vision loss, or unusual headaches.
If you have any of the above serious side effects during treatment with Lymepak, your doctor may stop your treatment.
Common side effects of Lymepak include:
- loss of appetite
- skin sensitivity to sunlight
- reversible discoloration of the surface of adult teeth
- lower than normal amount of red blood cells
These are not all the possible side effects of Lymepak.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Chartwell RX, LLC at 1-845-232-1683.
What is the dosage for Lymepak?
Adults And Pediatric Patients 8 Years Of Age And Older Weighing 45 kg And Above
Administer Lymepak (100 mg) tablet every 12 hours for 21 days.
Important Administration Instructions
- The usual dosage and frequency of administration of Lymepak differs from that of the other tetracyclines. Exceeding the recommended dosage may result in an increased incidence of adverse reactions.
- Administration of adequate amounts of fluid along with the tablets is recommended to wash down the tablet to reduce the risk of esophageal irritation and ulceration.
- If gastric irritation occurs, Lymepak may be given with food or milk. The absorption of doxycycline is not markedly influenced by simultaneous ingestion of food or milk.
What drugs interact with Lymepak?
- Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
- Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines, including Lymepak in conjunction with penicillin.
Antacids And Iron Preparations
- Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, bismuth subsalicylate, and iron-containing preparations.
- Absorption of tetracyclines is impaired by bismuth subsalicylate.
- There have been reports of intracranial hypertension associated with the concomitant use of isotretinoin and doxycycline.
- Avoid the concomitant use of isotretinoin and Lymepak because isotretinoin is also known to cause pseudotumor cerebri (benign intracranial hypertension.
Barbiturates And Anti-Epileptics
Drug/Laboratory Test Interactions
- False elevations of urinary catecholamines may occur due to interference with the fluorescence test.
Is Lymepak safe to use while pregnant or breastfeeding?
- Lymepak, like other tetracycline-class antibacterial drugs, may cause discoloration of deciduous teeth and reversible inhibition of bone growth when administered during the second and third trimester of pregnancy.
- Available data from published studies over decades have not shown a difference in major birth defect risk compared to unexposed pregnancies with doxycycline exposure in the first trimester of pregnancy.
- There are no available data on the risk of miscarriage following exposure to doxycycline in pregnancy.
- Based on available published data, doxycycline is present in human milk.
- There are no data that inform the levels of doxycycline in breastmilk, the effects on the breastfed infant, or the effects on milk production.
- Because there are other antibacterial drug options available to treat Lyme disease in lactating women and because of the potential for serious adverse reactions, including tooth discoloration and inhibition of bone growth, advise patients that breastfeeding is not recommended during treatment with Lymepak and for 5 days after the last dose.
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Related Disease Conditions
What Is Lyme Disease in Humans?
Lyme disease is a bacterial illness, which is spread by ticks when they bite the skin. Initially the disease affects the skin causing a reddish rash associated with flu-like symptoms. It takes weeks to months after the initial redness of the skin for its effects to spread throughout the body. Lyme disease can be treated with antibiotics. Lyme disease can be prevented by using tick avoidance techniques.
What Happens if You Go Untreated for Lyme Disease?
An inflammatory disease that is caused by the bacterium Borrelia burgdorferi, which is transmitted to humans by the deer tick. The first sign of Lyme disease is a red, circular, expanding rash, usually radiating from the tick bite, followed by flu-like symptoms and joint pains.
What Are the Three Stages of Lyme Disease?
Lyme disease is an infectious disease transmitted to humans via ticks. People spending time outdoors are at the highest risk of contracting this disease, especially in woody, bushy and grassy areas of the northeastern and mid-northern US. The three stages of Lyme disease can overlap with each other, and patients may not go through all of the stages. Antibiotics are used to treat Lyme disease, and patients recover faster if treated in the early stages.
Is Lyme Disease Contagious?
Lyme disease may be transmitted to humans via the bite of an infected tick. The bacterium Borrelia burgdorferi causes the disease and is passed to humans during a tick's blood meal. Lyme disease does not spread from person to person.
What Are the Symptoms of Lyme Disease in Humans?
Lyme disease is an infection that is transmitted by ticks and is the most common vector-borne disease in the US. It is caused by infection with the spiral-shaped bacteria Borrelia burgdorferi or Borrelia mayonii (rarely) that resides in the stomach of the ticks. The infected ticks of the genus Ixodes, commonly called black-legged deer ticks, transmit this disease to humans via tick bites.
Can Lyme Disease Be Cured?
Lyme disease is a multisystem illness caused by infection with the microorganism, Borrelia burgdorferi, and the body’s immune response to its infection. The signs and symptoms of Lyme disease usually appear one to 30 days after a tick bite, but most commonly between seven to 14 days. Lyme disease is known as a vector-borne disease.
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