- Schizophrenia Slideshow Pictures
- Take the Schizophrenia Quiz
- Physical Symptoms of Depression Slideshow
- What is lurasidone hydrochloride Latuda, and how does it work (mechanism of action)?
- What brand names are available for lurasidone hydrochloride Latuda?
- Is lurasidone hydrochloride Latuda available as a generic drug?
- Do I need a prescription for lurasidone hydrochloride Latuda?
- What are the side effects of lurasidone hydrochloride Latuda?
- What is the dosage for lurasidone hydrochloride Latuda?
- Which drugs or supplements interact with lurasidone hydrochloride Latuda?
- Is lurasidone hydrochloride Latuda safe to take if I'm pregnant or breastfeeding?
- What else should I know about lurasidone hydrochloride Latuda?
What is lurasidone hydrochloride Latuda, and how does it work (mechanism of action)?
Lurasidone (Latuda) belongs to a class of medications known as atypical antipsychotics. Other members of this class include clozapine (Clozaril), risperidone (Risperdal), aripiprazole (Abilify) and ziprasidone (Geodon). Atypical antipsychotics like lurasidone are considered the standard of care for treating schizophrenia. Additionally, in clinical studies lurasidone was shown to be effective in improving mood in many people struggling with bipolar depression. Lurasidone can be taken alone or with either lithium (Lithobid) or valproate (Depakote).
The exact mechanism of action of lurasidone is not known. It may work by blocking receptors for several neurotransmitters (chemicals that nerves use to communicate with each other) in the brain. It binds to dopamine and serotonin type 2 (5-HT2) receptors.
Lurasidone was approved for the treatment of schizophrenia in adults in October, 2010. Almost three years later in July, 2012 the FDA approved lurasidone for the treatment of depressive episodes associated with bipolar I disorder.
What are the side effects of lurasidone hydrochloride Latuda?
The most common side effects of lurasidone include:
- sleepiness or drowsiness,
- akathesia (restlessness or feeling a need to move around),
- difficulty moving,
- slow movements,
- muscle stiffness,
- tremor, and
Lurasidone may increase the risk of stroke that can lead to death in elderly patients with dementia. It is associated with an increased risk of suicidal thoughts or actions especially in children, teenagers, and young adults within the first few months of treatment. Neuroleptic malignant syndrome or NMS, a rare but serious disorder caused by antipsychotic medicines can occur.
Other side effects include:
- Involuntary movements of the face, tongue, or other body parts called tardive dyskinesia;
- high blood sugar (hyperglycemia);
- increased cholesterol and triglycerides;
- weight gain;
- increases in prolactin levels;
- a drop in white blood cell count;
- a decrease in blood pressure especially when rising too quickly from a sitting or lying position;
- seizures; and
- difficulty swallowing.
Quick GuideSchizophrenia: Symptoms, Types, Causes, Treatment
What is the dosage for lurasidone hydrochloride Latuda?
Lurasidone tablets should be taken with food (at least 350 calories) since administration with food significantly increases its absorption.
Schizophrenia: the recommended starting dose of lurasidone is 40 mg by mouth once a day. The dosage may be increased based on individual patient response or tolerability. For most patients, 40 to160 mg of lurasidone per day has been shown to be effective. The maximum recommended dose is 160 mg per day.
Depressive episodes associated with bipolar I disorder: the recommended starting dose of lurasidone is 20 mg by mouth once daily, alone or with lithium or valproate. The dosage may be increased based on individual patient response or tolerability. For most patients, 20 to 120 mg of lurasidone per day has been shown to be effective. The maximum recommended dose is 120 mg per day.
Kidney disease: dose adjustment is recommended in patients with moderate (creatinine clearance 30 to <50 ml/min) or severe kidney disease (creatinine clearance <30 ml/min). The recommended starting dose in such patients is 20 mg per day and the dose should not exceed 80 mg per day.
Liver disease: dose adjustment is recommended in patients with moderate (Child-Pugh Score= 7 to 9) or severe liver disease (Child-Pugh Score = 10 to15). The recommended starting dose in these patients is 20 mg per day. The dose in patients with moderate liver disease should not exceed 80 mg per day and the dose in patients with severe liver disease should not exceed 40 mg per day.
The safety and effectiveness of lurasidone has not been established in children.
Which drugs or supplements interact with lurasidone hydrochloride Latuda?
Lurasidone is primarily metabolized or broken down by CYP3A4 liver enzymes. Co-administration with medicines that interfere with the activity of these enzymes can alter the levels of lurasidone in the blood. Lurasidone should not be used concomitantly with strong CYP3A4 inhibitors such as ketoconazole (Extina, Kuric, Nizoral), clarithromycin (Biaxin), ritonavir (Norvir), voriconazole (VFEND), mibefradil (Posicor), and many other drugs due to the risk of increased blood levels of lurasidone. Grapefruit and grapefruit juice may also inhibit CYP3A4 enzymes and should be avoided in patients taking lurasidone.
Lurasidone should not be used concomitantly with strong CYP3A4 inducers such as rifampin (Rimactane), St. John's Wort, phenytoin (Dilantin), and carbamazepine (Tegretol) because blood levels of lurasidone may decrease, resulting in poor treatment outcomes. If used with moderate CYP3A4 inducer for 7 days or more, the dose of lurasidone may need to be increased.
Is lurasidone hydrochloride Latuda safe to take if I'm pregnant or breastfeeding?
Use of lurasidone in pregnant women has not been adequately evaluated. Due to the lack of conclusive safety data, lurasidone should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Lurasidone is classified as FDA pregnancy risk category B (no animal studies demonstrate harm).
Lurasidone was excreted in the milk of rats in animal studies. It is not known if lurasidone is excreted in human breast milk. Since many drugs are excreted in human milk and have the potential of causing harm to the nursing infant, a decision should be made to either discontinue nursing or taking lurasidone.
What else should I know about lurasidone hydrochloride Latuda?
What preparations of lurasidone hydrochloride Latuda are available?
Oral tablets: 20, 40, 60, 80, and 120 mg.
How should I keep lurasidone hydrochloride Latuda stored?
Tablets should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
lurasidone hydrochloride (Latuda) is an antipsycotic medication used for treating schizophrenia and bipolar disorder. Side effects, drug interactions, and use during pregnancy should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
Bipolar Disorder (Mania) Quiz: Test Your Emotional Wellness IQ
Who is at risk for developing bipolar disorder? Are you? Take this Bipolar Disorder Quiz to learn more about bipolar disorder, if...
Schizophrenia Quiz: What is Schizophrenia?
Schizophrenia is a complex psychiatric disorder. Learn more about the challenges of mental illness with the Schizophrenia Quiz....
Bipolar Disorder: Symptoms, Testing for Bipolar Depression
Bipolar disorder (once called manic depression) causes extreme mood shifts and can be disorienting. Our experts define bipolar...
Schizophrenia: Symptoms, Types, Causes, Treatment
What is schizophrenia? Learn about schizophrenia symptoms, signs, and treatment. Read about schizophrenia types such as paranoid...
Related Disease Conditions
Second Source article from WebMD...
Bipolar II Disorder
Second Source article from WebMD...
Schizophrenia and Electroconvulsive Therapy (ECT)
Second Source article from WebMD...
Second Source article from Government...
Second Source article from Government...
Schizophrenia is a disabling brain disorder that may cause hallucinations and delusions and affect a person's ability to...
Bipolar disorder (or manic depression) is a mental illness characterized by depression, mania, and severe mood swings. Treatment...
Obsessive Compulsive Disorder (OCD)
Obsessive compulsive disorder (OCD) is an anxiety disorder that causes a person to suffer repeated obsessions and compulsions....
Bipolar Disorder in Children and Teens
Bipolar disorder, or manic-depressive illness, is a disorder that causes unusual and extreme mood changes. Symptoms of bipolar...
Schizotypal Personality Disorder
Schizotypal personality disorder is characterized by odd behaviors, feelings, perceptions, and ways of relating to others that...
Bipolar Disorder vs. Schizophrenia
Bipolar disorder and schizophrenia are mental illnesses that share some risk factors and treatments. Symptoms of bipolar disorder...
Treatment & Diagnosis
Prevention & Wellness
- Exercise Might Boost Mental Function in People With Schizophrenia
- Abnormalities Found in Brains of Young Bipolar Patients Who Try Suicide
- Study Finds Need for Improved Schizophrenia Care
- Stem Cell Research Offers Clues About Schizophrenia
- People With OCD May Have Higher Odds for Schizophrenia: Study
- Gene Discoveries Could Shed New Light on Schizophrenia
- Antipsychotics Linked to Lower Brain Volume in Schizophrenia Patients
- Premature Death, Suicides Up Among People With Schizophrenia, Study Says
- Schizophrenia May Raise Dementia Risk in Older Adults
- App for Bipolar Disorder Being Tested
- Scientists Use Stem Cells to Study Bipolar Disorder
- Many Bipolar Patients Take Multiple Psychiatric Meds
- Schizophrenia Linked to Pregnancy Complications, Study Suggests
- Psychotherapy May Be Effective Alternate Treatment for Schizophrenia, Study Finds
- Bipolar Disorder Drug May Need Adjusting in Pregnancy, Study Finds
- Smoking in Pregnancy May Be Tied to Bipolar Disorder in Adult Offspring: Study
- Imaging Provides New Insights Into Schizophrenia
- Bipolar Disorder May Vary Depending on Weight, Eating Disorders
- Study Sees Link Between Mom's Flu, Bipolar Risk for Children
- Bipolar Disorder Drugs May 'Tweak' Genes Affecting Brain
- Scans May Reveal Pre-Schizophrenia Brain Changes
- Brain Scans Might Help Spot Risk for Bipolar Disorder
- Schizophrenia Patients Who Take Antipsychotics Live Longer, Study Says
- Pregnant Women With Bipolar Disorder May Have Higher Risk of Premature Birth
- Family History of Schizophrenia, Bipolar Disorder May Up Kids' Risk for Autism
- New Clues to Schizophrenia
- Genes Associated With Autism Also Related to Schizophrenia
- Bipolar Drug May Spur Weight Gain, Thyroid Problems: Review
- Study Looks at Deep Brain Stimulation in Bipolar Patients
- Psych Episode Near Childbirth May Presage Bipolar Disorder
- Bipolar Kids May Focus on Different Facial Features
- Heavy Meth Use Linked to Schizophrenia
- Catherine Zeta-Jones Treated for Bipolar Disorder
- Bipolar Disorder Often Untreated
- Anesthetic Shows Promise for Bipolar Disorder
- Schizophrenia Linked to Raised Risk of Injury While Hospitalized
- Creativity, Schizophrenia Share Similarities in the Brain
- Working-Memory Gene Linked to Schizophrenia
- Epilepsy Drugs for Bipolar Disorder: Fewer Suicides?
- Schizophrenia Linked to Early Death
- Scientists ID 3 New Candidate Genes for Schizophrenia
- Bipolar Teens at Greater Risk of Substance Abuse
- Bipolar Disorder Might Be Overdiagnosed
- Infection With Common Parasite Raises Schizophrenia Risk
- Genes Yield More Clues to Schizophrenia
- Invega Approved for Schizophrenia
Mental Health Resources
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top lurasidone hydrochloride Latuda Related Articles
Bipolar DisorderBipolar disorder (or manic depression) is a mental illness characterized by depression, mania, and severe mood swings. Treatment may incorporate mood-stabilizer medications, antidepressants, and psychotherapy.
Bipolar Disorder in Children and TeensBipolar disorder, or manic-depressive illness, is a disorder that causes unusual and extreme mood changes. Symptoms of bipolar disorder in children and teens include having trouble concentrating, behaving in risky ways, and losing interest in activities they once enjoyed. Treatment for bipolar disorder in children and teenagers incorporates psychotherapy and medications.
Bipolar Disorder QuizWho is at risk for developing bipolar disorder? Are you? Take this Bipolar Disorder Quiz to learn more about bipolar disorder, if you're at risk, and what you can do about it.
Bipolar SlideshowBipolar disorder (once called manic depression) causes extreme mood shifts and can be disorienting. Our experts define bipolar disorder, discuss bipolar symptoms, and describe bipolar medications that can help.
Bipolar Disorder vs SchizophreniaBipolar disorder and schizophrenia are mental illnesses that share some risk factors and treatments. Symptoms of bipolar disorder include mood changes and manic and depressive episodes. Symptoms of schizophrenia include unusual behavior, delusions, and hallucinations.
Obsessive Compulsive Disorder (OCD)Obsessive compulsive disorder (OCD) is an anxiety disorder that causes a person to suffer repeated obsessions and compulsions. Symptoms include irresistible impulses despite a person's realization that the thoughts are irrational, excessive hand washing, skin picking, lock checking, or repeatedly rearranging items. People with OCD are more likely to develop trichotillomania, muscle or vocal tics, or an eating disorder. Treatment for OCD includes psychotherapy, behavioral therapy, and medication.
SchizophreniaSchizophrenia is a disabling brain disorder that may cause hallucinations and delusions and affect a person's ability to communicate and pay attention. Symptoms of psychosis appear in men in their late teens and early 20s and in women in their mid-20s to early 30s. With treatment involving the use of antipsychotic medications and psychosocial treatment, schizophrenia patients can lead rewarding and meaningful lives.
Schizophrenia SlideshowWhat is schizophrenia? Learn about schizophrenia symptoms, signs, and treatment. Read about schizophrenia types such as paranoid schizophrenia, catatonic schizophrenia, and disorganized schizophrenia.
Schizophrenia QuizSchizophrenia is a complex psychiatric disorder. Learn more about the challenges of mental illness with the Schizophrenia Quiz.
Schizotypal Personality DisorderSchizotypal personality disorder is characterized by odd behaviors, feelings, perceptions, and ways of relating to others that interfere with one's ability to function. Medication and psychotherapy can help the sufferer to manage their symptoms.