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Yes. Systemic Lupus Erythematosus (Lupus) can cause seizures. Researchers report that seizures occur from lupus at the onset of their disease in less than 5% of patients. Seizures occur from lupus during their lifetime in approximately 10% of patients. Seizures are one of the classical 11 criteria that are used to diagnose. For more information, read our full medical article on lupus.