What is Lupkynis (voclosporin), and how is it used?
Lupkynis is a prescription medicine used with other medicines to treat adults with active lupus nephritis.
Lupkynis should not be taken with a medicine called cyclophosphamide. Talk with your healthcare provider if you are not sure if you take this medicine.
How does Lupkynis work?
Lupkynis is a calcineurin-inhibitor immunosuppressant. The mechanism of voclosporin suppression of calcineurin has not been fully established. Activation of lymphocytes involves an increase in intracellular calcium concentrations that bind to the calcineurin regulatory site and activate calmodulin binding catalytic subunit and through dephosphorylation activates the transcription factor, Nuclear Factor of Activated T-Cell Cytoplasmic (NFATc). The immunosuppressant activity results in inhibition of lymphocyte proliferation, T-cell cytokine production, and expression of T-cell activation surface antigens.
Studies in animal models also support a non-immunological role for calcineurin inhibition in kidney function to stabilize actin cytoskeleton and stress fibers in podocytes leading to increased podocyte integrity in glomeruli.
What are the side effects of Lupkynis
Lupkynis can cause serious side effects, including:
- Increased risk of cancer. People who take Lupkynis have an increased risk of getting certain kinds of cancer, including skin cancer and cancer of the lymph glands (lymphoma).
- Increased risk of infection. Lupkynis is a medicine that affects your immune system. Lupkynis can lower the ability of your immune system to fight infections. Serious infections can happen in people receiving Lupkynis that can lead to hospitalizations and can cause death. Call your healthcare provider right away if you have symptoms of an infection such as:
Lupkynis may cause serious side effects, including:
- kidney problems. Kidney problems are common side effects of Lupkynis and may be serious. Your healthcare provider may do certain tests to check your kidney function while you take Lupkynis.
- high blood pressure. High blood pressure is a common side effect of Lupkynis and may be serious. Your healthcare provider will monitor your blood pressure while you take Lupkynis and may ask you to check your blood pressure at home.
- nervous system problems. Nervous system problems are a common side effect of Lupkynis and may be serious. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these symptoms while taking Lupkynis. These could be signs of serious nervous system problems:
- high levels of potassium in your blood. Your healthcare provider may do certain tests to check your potassium levels while you take Lupkynis.
- a serious heart rhythm problem (QT prolongation).
- severe low red blood cell count (anemia).
The most common side effects of Lupkynis are:
These are not all the possible side effects of Lupkynis.
Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
You may also report side effects to www.fda.gov/medwatch.
What is the dosage for Lupkynis?
- Take Lupkynis exactly as your healthcare provider tells you to take it.
- Your healthcare provider may change your dose, if needed. Do not stop taking or change your dose of Lupkynis without talking to your healthcare provider.
- Swallow Lupkynis capsules whole. Do not break, crush, chew or dissolve Lupkynis capsules before swallowing. If you cannot swallow Lupkynis capsules whole, tell your healthcare provider.
- Take Lupkynis on an empty stomach, either 1 hour before or 2 hours after a meal and as close to 12 hours between doses as possible. Do not take your doses of Lupkynis less than 8 hours apart. If a dose is missed, take it as soon as possible within 4 hours after missing the dose. If more than 4 hours has passed, skip the missed dose and take the next dose at the regular time. Do not take 2 doses at the same time.
- If you take too much Lupkynis, call your healthcare provider or go to the nearest hospital emergency room right away.
- Talk with your healthcare provider if you have been taking Lupkynis for close to one year. It is not known if taking Lupkynis is safe or effective beyond a year.
What drugs interact with Lupkynis?
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Lupkynis may affect the way other medicines work, and other medicines may affect how Lupkynis works.
Do not take Lupkynis:
- with medicines known as strong CYP3A4 inhibitors such as ketoconazole, itraconazole, and clarithromycin.
- if you are allergic to voclosporin or any of the ingredients in Lupkynis. See the end of this Medication Guide for a complete list of ingredients in Lupkynis.
Before you take Lupkynis, tell your healthcare provider about all your medical conditions, including if you:
Is Lupkynis safe to use while pregnant or breastfeeding?
Tell your healthcare provider about all your medical conditions, including if you:
- are pregnant or plan to become pregnant when taking Lupkynis. Lupkynis may harm your unborn baby.
- are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you will take Lupkynis or breastfeed. You should not do both. After you stop your treatment with Lupkynis, do not start breastfeeding again until 7 days after your last dose of Lupkynis.
Lupkynis (voclosporin) is a prescription medicine used with other medicines to treat adults with active lupus nephritis, an autoimmune disease of the kidneys. Learn about the dosage, side effects and pregnancy safety for this immunosuppressant medication.
Multimedia: Slideshows, Images & Quizzes
What Is Lupus? Symptoms, Rash, and Treatment
What is Lupus? Learn about lupus symptoms like butterfly rash, joint pain and fatigue. Find causes, diagnosis, and treatments for...
Systemic Lupus Erythematosus Quiz: Test Your SLE IQ
This Lupus Quiz covers causes, signs, symptoms, facts, and treatments for this inflammatory autoimmune disease.
Picture of Systemic Lupus Erythematosus 1
A chronic inflammatory condition caused by an autoimmune disease. See a picture of Systemic Lupus Erythematosus (SLE) and learn...
Picture of Lupus
A chronic inflammatory condition caused by an autoimmune disease. See a picture of Lupus Rash and learn more about the health...
Picture of Systemic Lupus Erythematosus 2
Erythematous, edematous plaques appear in a "butterfly" distribution on the face. See a picture of Systemic Lupus Erythematosus...
Picture of Acute Systemic Lupus
Acute systemic lupus erythematosus. See a picture of Acute Systemic Lupus and learn more about the health topic.
Related Disease Conditions
Lupus (Systemic Lupus Erythematosus or SLE)
Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE).
Second Source article from WebMD
Second Source article from Government
What Is Usually the First Sign of Lupus?
Fatigue, fever, joint pain and weight changes are usually the first signs of lupus. Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system of the body attacks its healthy tissue. It affects joints, skin, brain, lungs, kidneys and blood vessels, leading to inflammation and tissue damage of the affected organs.
What Are the 4 Types of Lupus?
Lupus is an autoimmune disease in which the immune system attacks healthy tissue. It affects the joints, skin, brain, lungs, kidneys, and blood vessels, leading to inflammation and tissue damage in the affected organs.
How Do You Get Lupus?
Lupus is a chronic autoimmune disease in which the body’s immune system targets and attacks its own tissues and organs. The specific reason for getting lupus is unknown. Researchers understand, however, lupus involves some interaction among various factors including one’s genes, ethnicity, immune system, hormones, and the environment. Lupus is a lifelong disease that can directly or indirectly affect any part of the body.
What Are the Four Types of Lupus?
Lupus is an autoimmune disease in which the immune system attacks healthy tissue. It affects joints, skin, brain, lungs, kidneys and blood vessels, leading to inflammation and tissue damage of the affected organs. The four types are lupus dermatitis, systemic lupus erythematosus (SLE), drug-induced, and neonatal.
Is Lupus Contagious?
Systemic lupus erythematosus in an inflammatory disease. Symptoms and signs include joint pain, fever, and rash. Though lupus is incurable, early medical intervention can help to reduce inflammation and protect the affected individual's organs.
What Are the 12 Symptoms of Lupus?
Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system of the body attacks healthy tissue. It affects joints, skin, brain, lungs, kidneys and blood vessels, leading to inflammation and tissue damage of the affected organs. More than 90% of cases occur in females. Fatigue, weakness, joint pain and rash are some of the most common of the symptoms of lupus.
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Latest Medications News
Daily Health News
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.