lubiprostone, Amitiza

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Constipation Myths & Facts

What is lubiprostone, and how does it work (mechanism of action)?

Lubiprostone is an oral medication used for the treatment of idiopathic (due to an unknown cause) chronic constipation. Chronic constipation most commonly occurs because of slow transit of stool through the colon that allows too much fluid to be removed from the stool, leading to hard or lumpy stools, abdominal pain or discomfort, and straining during bowel movements, as well as difficulty passing stools. Signs and symptoms of chronic constipation can be reduced by increasing fluid in the stool. Lubiprostone causes an increase in the secretion of fluid into the intestines. The added fluid softens the stool and also may speed up transit of stool in the colon. Lubiprostone was approved by the FDA in January 2006.

What brand names are available for lubiprostone?

Amitiza

Is lubiprostone available as a generic drug?

GENERIC AVAILABLE: No.

Do I need a prescription for lubiprostone?

Yes.

What are the side effects of lubiprostone?

The most common side effects of lubiprostone are:

Nausea was reduced when lubiprostone was administered with food. Some patients may experience shortness of breath.

Quick Guide19 Constipation Myths and Facts

19 Constipation Myths and Facts

What is the dosage for lubiprostone?

The recommended dose of lubiprostone is 24 mcg taken orally twice daily with food and water

Which drugs or supplements interact with lubiprostone?

Lubiprostone has no known drug interactions.

Is lubiprostone safe to take if I'm pregnant or breastfeeding?

Use of lubiprostone in pregnant women has not been adequately evaluated during pregnancy.

It is not known whether lubiprostone is excreted in human milk.

What else should I know about lubiprostone?

What preparations of lubiprostone are available?

Capsules: 8 and 24 mcg

How should I keep lubiprostone stored?

Lubiprostone should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

Reference: FDA Prescribing Information

Quick Guide19 Constipation Myths and Facts

19 Constipation Myths and Facts

Summary

Lubiprostone (Amitiza) is a drug prescribed for the treatment of chronic constipation in adults, and irritable bowel syndrome (IBS) in women. Side effects drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking this medication.

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See more info: lubiprostone on RxList
Reviewed on 4/3/2015
References
Reference: FDA Prescribing Information

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