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- What is lubiprostone, and how does it work (mechanism of action)?
- What brand names are available for lubiprostone?
- Is lubiprostone available as a generic drug?
- Do I need a prescription for lubiprostone?
- What are the side effects of lubiprostone?
- What is the dosage for lubiprostone?
- Which drugs or supplements interact with lubiprostone?
- Is lubiprostone safe to take if I'm pregnant or breastfeeding?
- What else should I know about lubiprostone?
What is lubiprostone, and how does it work (mechanism of action)?
Lubiprostone is an oral medication used for the treatment of idiopathic (due to an unknown cause) chronic constipation. Chronic constipation most commonly occurs because of slow transit of stool through the colon that allows too much fluid to be removed from the stool, leading to hard or lumpy stools, abdominal pain or discomfort, and straining during bowel movements, as well as difficulty passing stools. Signs and symptoms of chronic constipation can be reduced by increasing fluid in the stool. Lubiprostone causes an increase in the secretion of fluid into the intestines. The added fluid softens the stool and also may speed up transit of stool in the colon. Lubiprostone was approved by the FDA in January 2006.
What are the side effects of lubiprostone?
The most common side effects of lubiprostone are:
- frequent bowel movements,
- fecal incontinence,
- decreased appetite, and
Quick GuideDigestive Disorders: 23 Constipation Myths and Facts
What is the dosage for lubiprostone?
The recommended dose of lubiprostone is 24 mcg taken orally twice daily with food and water
Which drugs or supplements interact with lubiprostone?
Lubiprostone has no known drug interactions.
Is lubiprostone safe to take if I'm pregnant or breastfeeding?
Use of lubiprostone in pregnant women has not been adequately evaluated during pregnancy.
It is not known whether lubiprostone is excreted in human milk.
What else should I know about lubiprostone?
What preparations of lubiprostone are available?
Capsules: 8 and 24 mcg
How should I keep lubiprostone stored?
Lubiprostone should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Lubiprostone (Amitiza) is a drug prescribed for the treatment of chronic constipation in adults, and irritable bowel syndrome (IBS) in women. Side effects drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking this medication.
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Related Disease Conditions
Stool Color, Changes in Color, Texture, and Form
Stool color changes can very from green, red, maroon, yellow, white, or black. Causes of changes of stool color can range from...
Constipation (Relief, Home Remedies, Treatment Medications)
Constipation is defined medically as fewer than three stools per week and severe constipation as less than one stool per week....
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms that include abdominal pain, bloating,...
IBS-D (Irritable Bowel Syndrome with Diarrhea)
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Treatment & Diagnosis
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Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top lubiprostone Related Articles
ConstipationConstipation is defined medically as fewer than three stools per week and severe constipation as less than one stool per week. Constipation usually is caused by the slow movement of stool through the colon. There are many causes of constipation including:
- Poor bowel habits
- Low fiber diets
- Abuse of laxatives
- Hormonal disorders and
- Diseases primarily of other parts of the body that also affect the colon
IBS SlideshowWhat is irritable bowel syndrome (IBS)? Learn about symptoms, causes, and foods that trigger IBS. Get lifestyle tips for managing IBS through diet and with IBS medications.
IBS vs IBD Differences and Similarities
IBS (irritable bowel syndrome) and IBD (inflammatory bowel disease) are both problems with the digestive tract (gastrointestinal or GI tract), but they are not the same disease. IBS is a functional disorder (a problem with the way the GI tract functions), and IBD is a disease that causes chronic prolonged inflammation of the GI tract, that can lead to ulcers and other problems that may require surgery. The most common forms of IBD are Crohn's disease and ulcerative colitis, or UC.
Researchers do not know the exact cause of either disease, but they believe that IBS may be caused and triggered by a variety of factors (foods, stress, and the nervous system of the GI tract), while IBD may be genetic or due a problem with the immune system.
Common symptoms of both diseases are an urgent need to have a bowel movement, diarrhea, nausea, vomiting, and abdominal pain and cramping.
There are differences between the signs and symptoms of irritable bowel syndrome and inflammatory bowel disease, for example, symptoms unique to IBD are:
- Joint pain or soreness
- Skin changes
- Rectal bleeding
- Eye redness or pain
- Unintentional weight loss
- Feeling tired
Symptoms unique to irritable bowel syndrome include:
- Sexual problems
- Abdominal bloating
- Whitish mucous in the stool
- Changes in bowel movements and in the way stools look
- An urgent need to urinate
- Urinating frequently
Treatment for IBS is with diet recommendations from a doctor or nutritionist, medication, and lifestyle changes like stress management and avoiding foods that trigger the condition. Treatments for IBD depend upon the type of disease, its symptoms, and health of the patient. Surgery may be necessary for some individuals.
Brown, AC, et al. "Existing Dietary Guidelines for Crohn's Disease and Ulcerative Colitis." Medscape.
Lehrer, J. "Irritable Bowel Syndrome." Medscape. Updated: Apr 04, 2017.
Rowe, W. "Inflammatory Bowel Disease." Medscape. Updated: Jun 17, 2016.
Romanowski, A, MS, RD. "Matching the Right Diet to the Right Patient." Medscape. Jan 27, 2017.
IBS-D Irrititable Bowel Syndrome with Diarrhea
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include
- intestinal gas (flatulence),
- loose stools,
- frequent stools,
- abdominal pain,
- diarrhea, and
New non-FDA approved IBS tests may help diagnose IBS and IBS-D. Treatment of IBS-D is geared to toward managing symptoms with diet, medication, and lifestyle changes.
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms that include abdominal pain, bloating, increased gas (flatulence), abdominal cramping, diarrhea, constipation, and food intolerance.
Two new tests are now available that may help diagnose irritable bowel syndrome with diarrhea and constipation (IBS-M) irritable bowel syndrome with diarrhea (IBS-D), and irritable bowel syndrome with constipation (IBS-C). Treatment for IBS includes diet changes, medications, and other lifestyle changes to manage symptoms.
Irritable Bowel Syndrome in Children
Irritable bowel syndrome (IBS) in children is a functional gastrointestinal disorder with signs and symptoms of:
- Abdominal pain
The cause of IBS is unknown, however, certain foods, stress, anxiety, and depression may contribute to the symptoms of IBS. There is no cure for IBS in children; however, medications, dietary changes, and stress management may relieve symptoms.
Stool Color ChangesStool color changes can very from green, red, maroon, yellow, white, or black. Causes of changes of stool color can range from foods a person eats, medication, diseases or conditions, pregnancy, cancer, or tumors. Stool can also have texture changes such as greasy or floating stools. Stool that has a uncharacteristically foul odor may be caused by infections such as giardiasis or medical conditions.