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- What is lubiprostone, and how does it work (mechanism of action)?
- What brand names are available for lubiprostone?
- Is lubiprostone available as a generic drug?
- Do I need a prescription for lubiprostone?
- What are the side effects of lubiprostone?
- What is the dosage for lubiprostone?
- Which drugs or supplements interact with lubiprostone?
- Is lubiprostone safe to take if I'm pregnant or breastfeeding?
- What else should I know about lubiprostone?
What is lubiprostone, and how does it work (mechanism of action)?
Lubiprostone is an oral medication used for the treatment of idiopathic (due to an unknown cause) chronic constipation. Chronic constipation most commonly occurs because of slow transit of stool through the colon that allows too much fluid to be removed from the stool, leading to hard or lumpy stools, abdominal pain or discomfort, and straining during bowel movements, as well as difficulty passing stools. Signs and symptoms of chronic constipation can be reduced by increasing fluid in the stool. Lubiprostone causes an increase in the secretion of fluid into the intestines. The added fluid softens the stool and also may speed up transit of stool in the colon. Lubiprostone was approved by the FDA in January 2006.
What are the side effects of lubiprostone?
The most common side effects of lubiprostone are:
- frequent bowel movements,
- fecal incontinence,
- decreased appetite, and
What is the dosage for lubiprostone?
The recommended dose of lubiprostone is 24 mcg taken orally twice daily with food and water
Which drugs or supplements interact with lubiprostone?
Lubiprostone has no known drug interactions.
Is lubiprostone safe to take if I'm pregnant or breastfeeding?
Use of lubiprostone in pregnant women has not been adequately evaluated during pregnancy.
It is not known whether lubiprostone is excreted in human milk.
What else should I know about lubiprostone?
What preparations of lubiprostone are available?
Capsules: 8 and 24 mcg
How should I keep lubiprostone stored?
Lubiprostone should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Quick GuideDigestive Disorders: 23 Constipation Myths and Facts
Lubiprostone (Amitiza) is a drug prescribed for the treatment of chronic constipation in adults, and irritable bowel syndrome (IBS) in women. Side effects drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking this medication.
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