What is lubiprostone? What is lubiprostone?
Lubiprostone is an oral medication used for the treatment of idiopathic (due to an unknown cause) chronic constipation. Chronic constipation most commonly occurs because of slow transit of stool through the colon that allows too much fluid to be removed from the stool, leading to hard or lumpy stools, abdominal pain or discomfort, and straining during bowel movements, as well as difficulty passing stools. Signs and symptoms of chronic constipation can be reduced by increasing fluid in the stool. Lubiprostone causes an increase in the secretion of fluid into the intestines. The added fluid softens the stool and also may speed up transit of stool in the colon. Lubiprostone was approved by the FDA in January 2006.
What brand names are available for lubiprostone?
Is lubiprostone available as a generic drug?
Do I need a prescription for lubiprostone?
What are the side effects of lubiprostone?
The most common side effects of lubiprostone are:
- frequent bowel movements,
- fecal incontinence,
- decreased appetite, and
What is the dosage for lubiprostone?
The recommended dose of lubiprostone is 24 mcg taken orally twice daily with food and water
Which drugs or supplements interact with lubiprostone?
Lubiprostone has no known drug interactions.
Is lubiprostone safe to take if I'm pregnant or breastfeeding?
Use of lubiprostone in pregnant women has not been adequately evaluated during pregnancy.
It is not known whether lubiprostone is excreted in human milk.
What else should I know about lubiprostone?
What preparations of lubiprostone are available?
Capsules: 8 and 24 mcg
How should I keep lubiprostone stored?
Lubiprostone should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Lubiprostone (Amitiza) is a drug prescribed for the treatment of chronic constipation in adults, and irritable bowel syndrome (IBS) in women. Side effects drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking this medication.
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Related Disease Conditions
Stool Color, Changes, Texture and Form
Stool color changes can very from green, red, maroon, yellow, white, or black. Causes of changes of stool color can range from foods a person eats, medication, diseases or conditions, pregnancy, cancer, or tumors. Stool can also have texture changes such as greasy or floating stools. Stool that has a uncharacteristically foul odor may be caused by infections such as giardiasis or medical conditions.
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome or IBS is a GI disorder with symptoms of constipation, abdominal pain, bloating, and gas. IBS treatment includes medications, dietary changes, and lifestyle changes.
Constipation is defined medically as fewer than three stools per week and severe constipation as less than one stool per week. Constipation usually is caused by the slow movement of stool through the colon. There are many causes of constipation including medications, poor bowel habits, low-fiber diets, laxative abuse, and hormonal disorders, and diseases primarily of other parts of the body that also affect the colon.
IBS-D (Irritable Bowel Syndrome with Diarrhea)
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include intestinal gas (flatulence), loose stools, frequent stools, abdominal pain, diarrhea, and nausea. New non-FDA approved IBS tests may help diagnose IBS and IBS-D. Treatment of IBS-D is geared to toward managing symptoms with diet, medication, and lifestyle changes.
IBS vs. IBD: Differences and Similarities
IBS (irritable bowel syndrome) and IBD (inflammatory bowel disease) are both problems with the digestive tract (gastrointestinal or GI tract), but they are not the same disease. Check out the center below for more medical references on IBS and IBD, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.