- Side Effects
- Drug Interactions
- What Else to Know
- Pregnancy & Breastfeeding
Generic Name: lutetium Lu 177 vipivotide tetraxetan
Brand Name: Pluvicto
Drug Class: Radiopharmaceuticals
What is Lutetium Lu 177 vipivotide tetraxetan, and what is it used for?
Lutetium Lu 177 vipivotide tetraxetan is a radioligand therapy used for a specific type of advanced prostate cancer. Radioligand therapy is a targeted radiation treatment in which a radioactive chemical (radionuclide) is administered as an intravenous (IV) injection. Radioligand therapy is used to specifically target the cancer cells and kill them, and limit the harm to normal cells that can result from traditional radiation therapies.
Lutetium Lu 177 vipivotide tetraxetan is used to treat prostate-specific membrane antigen (PSMA)-positive, metastatic castration-resistant prostate cancer (mCRPC). These advanced metastatic prostate cancers do not respond to chemotherapy or treatments that lower testosterone. PSMA is a prostate-specific protein that is present in great amounts in the membranes of the cancer cells.
Lutetium Lu 177 vipivotide tetraxetan is a radioconjugate drug that contains vipivotide tetraxetan, a substance (ligand) that identifies and binds to PSMA on the cancer cells. The radionuclide lutetium Lu 177 then delivers radiation to the PSMA-expressing cells and the surrounding cells and destroys them.
- Lutetium Lu 177 vipivotide tetraxetan can cause fetal harm
- May cause temporary or permanent infertility in males
- Lutetium Lu 177 vipivotide tetraxetan contributes to the patient’s overall long-term cumulative radiation exposure, which increases the risk for cancer
- Minimize radiation exposure to patients, medical personnel, and household contacts during and after treatment
- Before patient is released, explain necessary radioprotection precautions to follow to minimize radiation exposure to others:
- Patient must avoid close contact (less than 3 feet) for 2 days with others at home and for 7 days with children and pregnant women
- Patient must refrain from sexual activity for 7 days
- Patient must sleep in a separate bedroom from other adults for 3 days, from children for 7 days, and from pregnant women for 15 days
- Lutetium Lu 177 vipivotide may cause severe and life-threatening bone marrow suppression (myelosuppression) that can result in anemia, thrombocytopenia, leukopenia, and neutropenia
- Perform complete blood cell counts before and during treatment and titrate the dose accordingly or discontinue therapy
- Advise patients to contact their healthcare provider in case of myelosuppression symptoms of (e.g., tiredness, weakness, pale skin, shortness of breath, bleeding or bruising more easily than normal, or difficulty in stopping bleeding) or frequent infections with signs such as fever, chills, sore throat, or mouth ulcers
- Can be severely toxic to the kidney; ensure that patients increase oral fluid intake and advise patients to urinate as often as possible to reduce bladder radiation
- Perform kidney function tests before and during treatment and adjust dosage accordingly or discontinue therapy based on severity of renal toxicity
IMAGESBrowse through our medical image collection to see illustrations of human anatomy and physiology See Images
What are the side effects of lutetium Lu 177 vipivotide tetraxetan?
Common side effects of lutetium Lu 177 vipivotide tetraxetan include:
- All grades
- Decrease in lymphocytes
- Decrease in hemoglobin
- Decrease in leukocytes
- Decrease in platelets
- Decrease in neutrophils
- Low red blood cell count (anemia)
- Decrease in calcium
- Decrease in sodium
- Increase in potassium
- Increase in liver enzyme AST
- Increase in creatinine
- Dry mouth
- Decrease in appetite
- Weight loss
- Abdominal pain
- Low platelet count (thrombocytopenia)
- Urinary tract infection
- Increase in sodium
- Decreased lymphocytes
- Decreased hemoglobin
Less common side effects of lutetium Lu 177 vipivotide tetraxetan include:
- Swelling of extremities (peripheral edema)
- Acute kidney injury
- Taste perversion (dysgeusia)
- Fever (pyrexia)
- Decrease in platelets
- Decrease in leukocytes
- Decrease in neutrophils
- Urinary tract infection
- Acute kidney injury
- Decrease in calcium
- Decrease in appetite
- Abdominal pain
- Increase in AST
Rare side effects of lutetium Lu 177 vipivotide tetraxetan include:
- Grades 3-4
- Weight loss
- Peripheral edema
- Decrease in sodium
- Increase in creatinine
- Increase in potassium
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug.
Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
Latest Cancer News
Daily Health News
What are the dosages of lutetium Lu 177 vipivotide tetraxetan?
Injection, solution for IV use
- 1,000 MBq/mL (27 mCi/mL) single-dose vial
Castration-Resistant Prostate Cancer
- Indicated for the treatment of men with prostate-specific membrane antigen (PSMA)-positive, metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor (AR) pathway inhibition and taxane-based chemotherapy
- 7.4 GBq (200 mCi) IV every 6 weeks for up to 6 doses, or until disease progression, or unacceptable toxicity
- Management of adverse reactions may require temporary dose interruption (extending the dosing interval from every 6 weeks up to every 10 weeks), dose reduction, or permanent discontinuation
- If treatment delay persists for longer than 4 weeks, treatment must be discontinued
- Dose may be reduced by 20% to 5.9 GBq (160 mCi) once; do not re-escalate dose
- If further adverse reactions occur that would require an additional dose reduction, treatment must be discontinued
- Anemia, thrombocytopenia, leukopenia, or neutropenia
- Grade 2: Withhold until improvement to Grade 1 or baseline
- Grade 3 or higher: Withhold until improvement to Grade 1 or baseline, reduce dose by 20% to 5.9 GBq (160 mCi)
- Recurrent Grade >3 myelosuppression after 1 dose reduction: Permanently discontinue
- Withhold until improvement
- Confirmed serum creatinine increase (Grade 2 or higher)
- Confirmed creatinine clearance (CrCl) higher than 30mL/minute; calculate using Cockcroft-Gault equation with actual body weight
- Withhold until improvement/baseline and reduce dose by 20%
- CrCl confirmed increase 40% or higher from baseline AND
- CrCl confirmed higher than 40% decrease from baseline; calculate using Cockcroft-Gault equation with actual body weight
- Permanently discontinue
- Grade 3 or higher
- Recurrent renal toxicity after 1 dose reduction
- Grade 2: Withhold until improvement or return to baseline, consider reducing dose by 20%
- Grade 3: Withhold until improvement or return to baseline, reduce dose by 20% to 5.9 GBq (160 mCi)
- Recurrent Grade 3 dry mouth after 1 dose reduction: Permanently discontinue
Gastrointestinal (GI) toxicity
- Grade 3 or higher
- Not amenable to medical intervention: Withhold until improvement to Grade 2 or baseline, reduce dose by 20% to 5.9 GBq (160 mCi)
- Recurrent Grade 3 or higher GI toxicity after 1 dose reduction: Permanently discontinue
- Grade 3 or higher: Withhold until improvement to Grade 2 or baseline
Electrolyte or metabolic abnormalities
- Grade 2 or higher: Withhold until improvement to Grade 1 or baseline
- AST or ALT more than 5 times ULN in absence of liver metastases: Permanently discontinue
Other nonhematologic toxicity
- Permanently discontinue for
- Any unacceptable toxicity
- Any serious adverse reaction requiring treatment delay of >4 weeks
- Any recurrent Grade 3 or 4 or persistent and intolerable Grade 2 adverse reactions after 1 dose reduction
- Mild-to-moderate (CrCl 30-89 mL/minute): No dosage adjustment recommended; but frequently monitor kidney function and adverse reactions, as this group of patients may be at great risk of toxicity
- Severe (CrCl 15-29 mL/minute) or end-stage renal disease: Not studied
- No data are available
- Patient selection: Select patients with previously treated mCRPC using LOCAMETZ or another approved PSMA-11 imaging agent based on PSMA expression in tumors
- In case of radiation overdosage with lutetium Lu 177 vipivotide tetraxetan, the radiation absorbed dose is reduced by increasing the excretion of the radionuclide with increased urine output through diuresis.
- Based on the effective radiation dose that was applied, overdose is treated with additional supportive care measures.
What drugs interact with lutetium Lu 177 vipivotide tetraxetan?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Severe interactions of lutetium Lu 177 vipivotide tetraxetan include:
- Lutetium Lu 177 vipivotide tetraxetan has serious interactions with at least 13 different drugs.
- Lutetium Lu 177 vipivotide tetraxetan has moderate interactions with at least 15 different drugs.
- Lutetium Lu 177 vipivotide tetraxetan has no known minor interactions.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information.
Check with your doctor or health care provider if you have any questions about the medication.
What else should I know about lutetium Lu 177 vipivotide tetraxetan?
- Increase oral fluid intake and urine output as much as possible to reduce the risk of bladder radiation
- Follow all the precautions during and after treatment as advised by your healthcare provider to minimize radiation exposure to others
- Seek medical help immediately in case of symptoms such as fatigue, weakness, shortness of breath, bleeding disorders, or frequent infections
Pregnancy and breastfeeding
- There are no animal reproduction studies, however, based on the mechanism of action, all radiopharmaceutical agents including lutetium Lu 177 vipivotide tetraxetan can cause fetal harm.
- Pregnant persons should avoid close contact (less than three feet) with patients treated with lutetium Lu 177 vipivotide tetraxetan, for 7 days after the treatment, and in addition, avoid sleeping in the same room for 15 days after the treatment.
- Male patients with female partners of reproductive potential must use effective contraception during treatment and for 14 weeks after the last dose.
- Cumulative dose of 44.4 GBq may cause temporary or permanent infertility in males.
- There are no data on presence in breast milk or its effects on breastfed infants or milk production.
Lutetium Lu 177 vipivotide tetraxetan is a radioligand therapy used for a specific type of advanced prostate cancer. Lutetium Lu 177 vipivotide tetraxetan can cause fetal harm. May cause temporary or permanent infertility in males. Side effects of Lutetium Lu 177 vary depending on the grade. Male patients with female partners of reproductive potential must use effective contraception during treatment and for 14 weeks after the last dose. There are no data on presence in breast milk or its effects on breastfed infants or milk production.
Multimedia: Slideshows, Images & Quizzes
Signs of Prostate Cancer: Symptoms, PSA Test, Treatments
What is prostate cancer? Prostate cancer is the most common cancer in men. Learn the signs and symptoms of prostate cancer, along...
Erectile Dysfunction (ED) Causes and Treatment
Having erection problems? What is erectile dysfunction (ED)? Learn about erectile dysfunction causes and treatments such as drugs...
Enlarged Prostate (BPH) Symptoms, Diagnosis, Treatment
Benign Prostatic Hyperplasia (BPH) is a condition cause by an enlarged prostate. Get more information on how an enlarged prostate...
Men's Health: Natural Ways to Boost Testosterone
Find out from WebMD what you can do to raise your testosterone levels naturally, including changes to your diet and lifestyle.
Screening Tests Every Man Should Have
Getting the right screening test at the right time is one of the most important things a man can do for his health. Learn at what...
Prostate Cancer Quiz
Is prostate cancer the most common cancer in men? Take this prostate cancer quiz to find out and learn the causes, symptoms, and...
Benign Prostatic Hyperplasia (Enlarged Prostate) Quiz
Take the Enlarge Prostate Quiz and challenge your knowledge of prostate problems. Learn causes, symptoms, treatments, and...
Erectile Dysfunction (Impotence) Quiz: Causes & Treatment
Did you know that certain medical condition may be responsible for ED? Some causes of impotence are medically treatable and...
Picture of Prostate Gland
A gland within the male reproductive system that is located just below the bladder. See a picture of Prostate Gland and learn...
Picture of Prostate
Side View of the Prostate. The prostate is a walnut-sized gland located between the bladder and the penis. See a picture of the...
Picture of Male Pattern Baldness
The male pattern baldness (MPB) form of androgenetic alopecia (there is also a female pattern baldness) accounts for more than...
Men's Health: What Foods Should Men Eat for Good Health?
What foods have the most health benefits for men? For losing weight, gaining muscle, and lowering your risk of prostate cancer,...
Men's Health: Guys, Don't Make These 10 Health Mistakes
Are you making these common mistakes when it comes to your health? WebMD shows you how to be smartwer when it comes to seeing the...
Things That May Slow Prostate Cancer Progression
Studies are ongoing, but are there certain foods and healthy practices that can slow the growth of tumors in the prostate? Learn...
Related Disease Conditions
What Are the 5 Warning Signs of Prostate Cancer?
Prostate cancer rarely produces symptoms in the early stage; however, few signs can help in detecting prostate cancer.
The prostate is a gland that is part of the male reproductive system and is located between the bladder and penis. Signs and symptoms of prostate problems include painful ejaculation, burning or pain while urinating, blood in the urine or semen, dribbling urine, frequent urination, urinary incontinence, and pain in the lower back, hips, upper thighs, or the pelvic or rectal area. Common causes of prostate problems in men are prostatitis, enlargement of the prostate gland (benign prostatic hyperplasia (BPH), and prostate cancer. Causes of prostate problems can assist in diagnosing prostate cancer. Treatments for prostate problems include medications, surgery, and hormone or radiation therapy.
Prostatitis (Inflammation of the Prostate Gland)
Prostatitis is an inflammation of the prostate gland. Signs and symptoms of prostatitis include painful or difficulty urinating; fever; chills; body aches; blood in the urine; pain in the rectum, groin, abdomen, or low back; and painful ejaculation or sexual dysfunction. Causes of prostatitis include STDs, bacteria from urinary tract infections, or E. coli. Treatment for prostatitis depends on if it is a bacterial infection or chronic inflammation of the prostate gland.
Is Drinking a Lot of Water Good for Your Prostate?
Doctors recommend drinking six to eight glasses of water (or 1.5 to 2 liters) daily. For prostate problems, limit water intake before going to bed at night. This will keep you from waking up at night to urinate repeatedly.
What Is the Fastest Way To Cure Erectile Dysfunction?
Learn about the symptoms of erectile dysfunction, treatment options, and the quickest way to help you resolve the condition. It is more likely that you'll develop erectile dysfunction as you get older, but aging itself does not cause erectile dysfunction. Many factors can cause erectile dysfunction, including those that affect your endocrine, vascular, and nervous systems. What is erectile dysfunction, and what are the signs and symptoms? Learn about the risks and causes of erectile dysfunction and what treatments are available for erectile dysfunction.
Erectile Dysfunction (ED, Impotence)
Erectile dysfunction (ED, impotence) is the failure to achieve or maintain an erection. There are many potential underlying causes of erectile dysfunction, including stress and emotional problems, brain dysfunction, problems with blood supply to the penis, and structural problems with the penis.
Prostate Cancer Staging and Survival Rates
The prognosis for prostate cancer, as with any cancer, depends on how advanced the cancer has become, according to established stage designations. The patient's PSA score at diagnosis, as well as their Gleason score (the grading system used to determine the aggressiveness of prostate cancer) determines the prognosis and final stage designation. Prostate cancer has a high survival rate in general, but your chances depend on the stage of the cancer.
How Does Prostate Cancer Kill You in the End?
Prostate cancer is cancer of the prostate gland in men. Death from prostate cancer most often happens when cancer has spread (metastasized) to other organs in the body.
Men's Health: Keys to a Healthy Life
Second Source article from Government
How Quickly Does Prostate Cancer Spread?
Prostate cancer is a cancer that develops in the prostate gland in men and it is one of the most common types of cancer. In some cases, it can take up to eight years to spread from the prostate to other parts of the body (metastasis), typically the bones. In other cases, it may be more aggressive.
Early Prostate Cancer
Second Source article from Government
Atherosclerosis and Erectile Dysfunction
Second Source article from WebMD
Prostate Cancer: Erectile Dysfunction
Second Source article from The Cleveland Clinic
Does an Enlarged Prostate Affect a Man Sexually?
An enlarged prostate can cause sexual problems in men. Sexual problems, such as erectile dysfunction or ejaculation problems, may occur in men with noncancerous enlargement of the prostate (benign prostatic hyperplasia or BPH).
Gynecomastia (Enlarged Male Breasts)
Gynecomastia, an enlargement of the gland tissue in the male breast is caused by an imbalance of hormones. Certain medical conditions may also lead to gynecomastia such as cirrhosis, malnutrition, disorders of the male sex organs, kidney failure, thyroid disorders, and medications. Gynecomastia is generally treated with medication, and if necessary, surgery.
What Happens If You Don't Treat Prostate Cancer?
If prostate cancer is left untreated, it may grow and possibly spread out of the prostate gland to the local tissues or distant sites such as liver and lungs.
Prostatitis vs. BPH (Enlarged Prostate): What Is the Difference?
Prostatitis and BPH (benign prostatic hyperplasia, enlarged prostate gland) are both conditions of the prostate gland. There are four types of prostatitis that can be caused by infections (usually bacterial) or other health conditions or problems, acute bacterial prostatitis (type I), chronic bacterial prostatitis (type II), chronic prostatitis and chronic pelvic pain syndrome (type III), and asymptomatic inflammatory prostatitis (type IV). BPH is inflammation of the prostate gland, and most men have the condition by age 50. Doctor's don't know what causes this inflammation, but they theorize that it may be related to hormones. Both of these conditions can cause similar symptoms like low back pain, pain during urination, or difficulty or the inability to urinate. However, prostatitis has many more symptoms and signs than BPH, and they based on the type of prostatitis. Examples include low back pain and/or abdominal pain, painful urination, fever, chills, feeling tired, recurrent urinary tract infections (UTIs), painful urination intermittently, intermittent obstruction urinary tract symptoms (frequent, painful, or incomplete urination), pelvic pain and/or discomfort, pain with ejaculation, and erectile dysfunction (ED). If you think you have either of these conditions contact your doctor or other health care professional. Bacterial prostatitis can be cured with antibiotics; however, there is no cure for BPH.
Can Erectile Dysfunction Caused By Diabetes Be Reversed?
Erectile dysfunction is a frustrating condition where your penis cannot get or maintain an erection firm enough for sex. There is no specific treatment to reverse damage to blood vessels caused by diabetes, there are several options to help you have erections.
Enlarged Prostate (BPH, Benign Prostatic Hyperplasia)
Benign prostatic hyperplasia (BPH or enlarged prostate) is very common in men over 50 years of age. Half of all men over the age of 50 develop symptoms of BPH, but few need medical treatment. This noncancerous enlargement of the prostate can impede urine flow, slow the flow of urine, create the urge to urinate frequently and cause other symptoms like complete blockage of urine and urinary tract infections. More serious symptoms are urinary tract infections (UTIs) and complete blockage of the urethra, which may be a medical emergency. BPH is not cancer. Not all men with the condition need treatment, and usually is closely monitored if no symptoms are present. Treatment measures usually are reserved for men with significant symptoms, and can include medications, surgery, microwave therapy, and laser procedures. Men can prevent prostate problems by having regular medical checkups that include a prostate exam.
What Is Stage IV Prostate Cancer Life Expectancy?
The survival rate in most people with advanced prostate cancer is 30 percent at the fifth year of diagnosis. This means around 70 percent of the diagnosed men are not alive in the fifth year after diagnosis.
What Are the Five Stages of Prostate Cancer?
The Gleason grading system grades prostate cancer from 1 to 5. According to cells’ appearances under a microscope, this system grades the most common (primary) and second most common (secondary) patterns of cells in a tissue sample collected via biopsy.
How Do You Check for Prostate Cancer at Home?
Prostate cancer is highly treatable in its early stages. Thanks to the increase in cancer screening, cancer is also being diagnosed early.
What Is the Most Accurate Test for Prostate Cancer?
The most accurate test for detecting prostate cancer is a prostate biopsy, which involves taking a tissue sample from the prostate and examining it under a microscope.
What Foods Kill Prostate Cancer?
Prostate cancer refers to the uncontrolled growth of cells in the prostate gland. There is no particular food or recipe that can directly kill prostate cancer cells. Some foods that may be helpful in prostate cancer recovery and relapse prevention include foods containing lycopene, beans, green tea, cruciferous vegetables and fruit like cranberries, strawberries, blueberries and pomegranates.
Male Breast Cancer
Male breast cancer accounts for 1% of all breast cancers, and most cases are found in men between the ages of 60 and 70. A man's risk of developing breast cancer is one in 1,000. Signs and symptoms include a firm mass located below the nipple and skin changes around the nipple, including puckering, redness or scaling, retraction and ulceration of the nipple. Treatment depends upon staging and the health of the patient.
What Are the Best Three Exercises for Erectile Dysfunction?
What Are the Best Three Exercises for Erectile Dysfunction? Learn whether exercises can help and what other treatments can help to relieve your symptoms.
Prostate Cancer Early Signs and Symptoms
Difficulty with urination – frequency, weak stream, trouble getting started, etc. – is usually the first sign of prostate cancer. But these and other early symptoms of prostatic cancer can also come from benign prostate conditions, so diagnostic testing is important, including PSA tests and digital rectal exam.
What Is the Best Medicine for Erectile Dysfunction?
The best medicine for erectile dysfunction (ED) depends on the cause of your condition, as well as your budget and lifestyle.
Men's health is an important component to a happy lifestyle and healthy relationships. Eating healthy, exercise, managing stress, and knowing when to have medical tests for a particular age is key to disease prevention in men.
Prostate cancer is the most common cancer in men after skin cancer. Risk factors include age, family history, ethnicity, and diet. Prostate cancer is diagnosed by a digital rectal exam, prostate-specific antigen (PSA) test, and prostate biopsy. Symptoms may include frequent need to urinate, incontinence, pain, blood in the urine, fatigue, and more. Prognosis and treatment depend on cancer staging. Watchful waiting, surgery, radiation, cryotherapy, and other management strategies are available. Research and clinical trials strive to find new and better treatments for prostate cancer.
What Are the Risk Factors for Prostate Cancer?
All men are at risk of prostate cancer; however, some men are at more risk than others. Apart from being male, current risk factors for prostate cancer include the following.
Do Urologists Treat Erectile Dysfunction?
Urologists are the doctors that can examine, diagnose and treat your erectile dysfunction (ED).
Can Prostate Cancer Be Completely Cured?
Prostate cancer is the second most common cancer in men. Due to routine screening of prostate-specific antigen (PSA) levels in the United States, nearly 90% of prostate cancers get detected in early stages. When found early, there are several treatment options available and prostate cancer has a high chance of getting cured.
Prostate Cancer Treatment: Focal Therapy and Other Experimental Treatments
Several new and experimental treatments for prostate cancer are under study, including treatments that use ultrasound, lasers, tissue-freezing gas, and new ways of administering radiation. These new methods are types of focal therapy, that is, treatment focused on the cancer cells in the prostate, rather than systemic therapy that administers medications or other treatments to the whole body with the aim of treating the prostate.
What Is the Main Cause of Erectile Dysfunction?
Penile erection is a complex process in which the brain, nerves, muscles and blood vessels play a major role. The main causes of erectile dysfunction include psychological and health conditions, medications, trauma, and lifestyle factors.
How Does a Male Get a UTI?
Urinary tract infections (UTIs) in men are less common, but they can occur when E. coli bacteria enters the urinary tract through the urethra. Learn about causes and risk factors.
What Are the First Signs of Prostate Problems?
The first signs and symptoms of prostate disorder usually include problems with urination. Please consult your doctor if you experience any of the signs and symptoms to avoid the worsening of the prostate problems.
Prostate Cancer Facts
Prostate cancer is a leading cause of cancer and cancer death in males; in some men, identifying it early may prevent or delay metastasis and death from prostate cancer. The prostate is a walnut-shaped gland that is a part of the male reproductive system that wraps around the male urethra at it exits the bladder. Prostate cancer is common in men over 50 years of age, with the risk of developing prostate cancer increases with aging.
Early-Stage Prostate Cancer Treatment
If prostate cancer is detected early and appears to be slow-growing, invasive procedures, chemotherapy, radiation and other approaches can sometimes do more harm than good. Many prostate cancer treatments come with side effects, like incontinence or impotence, so it’s in the patient’s interest to put off invasive treatments as long as is medically safe. Active surveillance is where doctors "watch and wait" for changes that could prompt medical intervention.
How Is Prostate Cancer Diagnosed?
Prostate cancer is largely a disease of men over 40, so it’s around this age doctors recommend the first prostate screening. The first exam is a blood test to determine if there are abnormal prostate specific antigen (PSA) levels in your blood – PSA is produced by the prostate. If the PSA is high, your doctor will perform a digital rectal exam, during which the doctor feels your prostate from inside your rectum with a gloved finger. Other diagnostic tests include an endoscopic biopsy of tumor tissue for analysis in a lab.
What Are the Top 4 Causes of Male Infertility?
Infertility is a condition where a heterosexual couple cannot conceive a baby after having unprotected sexual intercourse for six to twelve months. The top four causes of male infertility are sperm disorders, physical issues, genetic disorders and gender transition.
Where Is the Prostate?
The prostate gland, commonly known as the prostate, is one of the male reproductive organs located just below the bladder, above the penis, and in front of the rectum. It is connected to the penis by a tube (urethra) that empties urine from the bladder. The size and shape of the prostate are similar to a walnut.
What Are the Signs of Male Menopause?
Andropause is the name used to refer to the symptoms men get when going through male menopause.
What Are the Key Signs of Prostate Cancer?
Learn the 23 key signs that may indicate the presence of prostate cancer below.
What Is the Latest Treatment for Prostate Cancer?
Prostate cancer affects 1 in 5 men. Learn how it is diagnosed and treated by doctors.
Can Prostate Cancer Kill You?
Yes. Like any other cancer, prostate cancer is a potential killer. However, this is true of the metastasized prostate cancer that has remained undiagnosed for a long time. The disease is vastly curable when diagnosed early.
Male menopause refers to the decline in testosterone production in men. As men age, they often experience many of the same symptoms that women experience in menopause. Testosterone replacement therapy may relieve some of these symptoms.
Prostate Cancer: Radical Prostatectomy Surgery
Radical prostatectomy, or surgical removal of the entire prostate gland, isn’t typically the first choice in prostate cancer treatment. Sometimes a radical approach is necessary to keep the cancer from metastasizing, however. Some cases are too severe or diagnosed too late for drugs or radiation to have much effect. In these cases, treatment teams may opt for a radical prostatectomy, despite potential side effects like impotence and incontinence.
What Are the 4 Stages of Prostate Cancer?
Prostate cancer is cancer that develops in the prostate glands of men. It is one of the most common types of cancer. It is usually seen in men older than 50 years of age. The prostate is a small walnut-shaped gland in men that produces seminal fluid. This fluid nourishes and transports sperm.
Is Male Infertility Permanent?
Male fertility is not necessarily permanent, and whether it is treatable depends on the underlying cause. However, one-third of male infertility cases have no known cause.
What Are the Main Causes of Prostate Cancer?
The exact cause of prostate cancer is not known. Studies have revealed that prostate cancer occurs when the deoxyribonucleic acid (DNA) or genetic material of a normal prostate cell undergoes a sudden and abnormal change called a mutation.
Prostate Cancer Treatment: Hormonal Therapy
Prostate cancer is highly sensitive to, and dependent on, the level of the male hormone testosterone, which drives the growth of prostate cancer cells. Testosterone belongs to a family of hormones called androgens, and today front-line hormonal therapy for advanced and metastatic prostate cancer is called androgen deprivation therapy (ADT).
Can Prostate Cancer Be Detected by a Blood Test?
Prostate cancer develops in the prostate gland of men. It is one of the most common types of cancer. It is usually seen in men older than 50 years of age. The prostate is a small walnut-shaped gland that produces seminal fluid required to nourish and transports sperm. Prostate cancer develops slowly. More often, it is confined to the prostate gland, requiring minimal or no treatment.
Prostate Infection: Causes, Symptoms, and Remedies
If the prostate gland becomes swollen and tender, it is called prostatitis or prostate infection. The prostate gland is a walnut-shaped organ that lies just below a man's urinary bladder.
Prostate Cancer: Radiation, Brachytherapy and Radiopharmaceuticals
Radiation treatment for prostate cancer is a powerful tool at doctors’ disposal. Using radiation vs. surgery or other invasive treatments to kill cancer cells may still cause side effects, but ideally they are less severe. Radiation therapy can be performed via external beam therapy (EBRT) or the placement of radioactive seeds into the prostate (prostate brachytherapy) or using radioactive drugs (radiopharmaceuticals).
How Do You Treat Male PE?
Premature ejaculation (PE) may be embarrassing, but it can be treated. Learn about behavioral, psychological, and pharmacological treatment methods.
Prostate Cancer Treatment: Chemotherapy, Bone-Targeted and Immune Therapy
Doctors may introduce chemotherapy and immune therapy if other measures fail to cure a case of prostate cancer. However, unlike with other forms of cancer, chemotherapy isn’t the first choice for early prostate cancer. Immune therapy uses the body's own immune system to attack the prostate tumor, while bone-targeted therapy aims to preserve bone and prevent metastasis.
How Does a Doctor Diagnose Prostate Cancer?
The prostate gland or prostate is a part of the male reproductive system. It is a small (almost walnut-sized) gland located just below the bladder and in front of the rectum (the last part of the large bowel), surrounding the urethra (the tube carrying urine out of the bladder). The prostate has two main functions: producing and storing fluid that helps make semen and regulating bladder control.
When Should You Screen for Prostate Cancer?
Screening for prostate cancer helps detecta tumor early, enabling timely treatment and prevention of any complications. According to the American Cancer Society (ACS), the decision to get screened should be made by men in consultation with their doctor. The doctor needs to counsel the men about the uncertainties involved in the screening process, the risks and potential benefits of getting screened for prostate cancer.
How Can I Make My Prostate Strong?
You can strengthen a weak prostate by eating healthy, staying active, maintaining a healthy weight, managing stress, and getting enough sleep.
The Early Signs of Prostate Cancer
Prostate cancer in its early stages usually causes no signs and symptoms. Screening can help detect the cancer early.
What Happens If You Are Diagnosed With Prostate Cancer?
A diagnosis with prostate cancer does not mean that a person’s life has come to a full stop. Many people with prostate cancer, if diagnosed early, go on to live for many years. If the disease is diagnosed in very early stages, the doctor may only keep the patient under surveillance and treat as required. However, the patient must make some changes in their life during and after the treatment.
How Is Prostate Cancer Screening Done?
There are no standard or routine screening tests for prostate cancer. Studies are being done to find ways to make prostate-specific antigen (PSA) testing more accurate for early cancer detection.
How Common Is Male Infertility?
In at least 50% of infertility cases, a male factor is a contributing cause. This indicates that about 10% of males trying to conceive suffer from male infertility.
Treatment & Diagnosis
- Mental Health: Irritable Male Syndrome
- Erectile Dysfunction (Impotence)
- Prostate Cancer
- Enlarged Prostate (Benign Prostatic Hyperplasia)
- Male Menopause
- Prostate Health
- Male Breast Cancer
- Fertility: The Male Side of Fertility
- Prostate Cancer Treatment Update
- Hair Loss in Males
- Men's Health: Your Prostate Health
- Breast Cancer: The Male View on Survival and Support
- Male Infertility Issues-- Sheldon Marks, MD
- Impotence Erectile Dysfunction FAQs
- Enlarged Prostate BPH FAQs
- Prostate Cancer FAQs
- 8 Natural Remedies for Erectile Dysfunction (ED)
- Prostate Cancer - New Criteria
- Prostate Cancer Risk May Be Lowered By Vitamin E
- Erectile Dysfunction Drugs: Drug Interactions
- Can Alcoholism Cause Male Breast Enlargement?
- How Common and Dangerous Is Male Breast Cancer?
- Is Prostate Cancer Genetic?
- What Is the Prostate Cancer TNM Stage?
- What Does Prostate Cancer Do to You?
- How Do You Develop Prostate Cancer?
- What Are the Early Signs of Prostate Cancer?
- Does Stress Affect Male Fertility?
- Male Menopause
- Erection Protection: Is Erectile Dysfunction (ED) Prevention Possible?
- Effective Erectile Dysfunction Treatments: What to Do After an Impotence Diagnosis
- What Causes Erectile Dysfunction (Impotence)?
- Erectile Dysfunction and Weight Loss
- Men's Health: 10 Healthy Habits, Performance Boost
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.