- Habits That Can Help You Lose Weight Slideshow
- Lose Weight Without Dieting Slideshow
- Surprising Sources of Hidden Sugar Slideshow
- What is lorcaserin HCL (Belviq), and how does it work (mechanism of action)?
- What brand names are available for lorcaserin HCL (Belviq)?
- Is lorcaserin HCL (Belviq) available as a generic drug?
- Do I need a prescription for lorcaserin HCL (Belviq)?
- What are the side effects of lorcaserin HCL (Belviq)?
- What is the dosage for lorcaserin HCL (Belviq)?
- Which drugs or supplements interact with lorcaserin HCL (Belviq)?
- Is lorcaserin HCL (Belviq) safe to take if I'm pregnant or breastfeeding?
- What else should I know about lorcaserin HCL (Belviq)?
What is lorcaserin HCL (Belviq), and how does it work (mechanism of action)?
Lorcaserin is an orally administered medication that promotes weight loss. It is used with diet and exercise in overweight adults with a weight-related medical problem or obese adults to lose weight and keep it off. Lorcaserin is a serotonin 2C (5-HT2C) receptor agonist. Although the exact mechanism of action is not known, lorcaserin is thought to selectively stimulate 5-HT2C receptors in the hypothalamus, the area of the brain known to play a major role in regulating hunger and food intake. By activating these receptors, lorcaserin may decrease food consumption by decreasing appetite and making a person feel full even after eating less food than usual.
Lorcaserin was approved by the FDA in June, 2012. Use and distribution of lorcaserin is under strict control by the federal government as it has a potential for abuse and drug dependence. As such, lorcaserin is classified as a schedule IV controlled substance.
What are the side effects of lorcaserin HCL (Belviq)?
The most common side effects are:
Other less common but serious side effects associated with lorcaserin include:
What is the dosage for lorcaserin HCL (Belviq)?
The recommended dose of lorcaserin is 10 mg administered by mouth twice a day. Lorcaserin may be taken without regard to meals. Lorcaserin should be discontinued in patients who fail to achieve at least a 5% weight loss by week 12 since these patients are not likely to experience meaningful weight loss with continued treatment.
Which drugs or supplements interact with lorcaserin HCL (Belviq)?
Due to the potential risk for serotonin syndrome, a rare but serious disorder caused by abnormally high levels of serotonin, extreme caution should be exercised when using lorcaserin with certain medications. Examples include triptans (a type of medication used for treating migraine headaches), linezolid (Zyvox), tryptophan, lithium (Lithobid, Eskalith), tramadol (Ultram), St. John's Wort, dextromethorphan (a common over-the-counter medicine for treating colds and coughs), and various classes of commonly used antidepressants including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MOAIs).
Lorcaserin may increase blood levels of drugs broken down by CYP 2D6 liver enzymes. Caution must be used if lorcaserin is used with drugs that are extensively metabolized via this pathway.
Is lorcaserin HCL (Belviq) safe to take if I'm pregnant or breastfeeding?
Weight loss offers no potential benefit during pregnancy and may harm the unborn baby. Use of lorcaserin during pregnancy is not recommended. Lorcaserin is classified as FDA pregnancy risk category X (animal and/or human data demonstrating fetal abnormalities).
It is not known if lorcaserin is excreted in breast milk. Many drugs are excreted in human milk and have the potential of causing harm to the nursing infant. A decision should be made to either discontinue nursing or taking the drug.
Lorcaserin HCL (Belviq) is a drug that promotes weight loss by affecting the brain's hypothalamus. People taking lorcaserin HCL eat less and feel fuller. Side effects, drug interactions, and use during pregnancy should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
Childhood Obesity Quiz: Test Your Medical IQ
Childhood obesity has reached epidemic proportions. Take the Childhood Obesity Quiz to test your knowledge of the facts and...
Top Diets: The Best Dieting Tips Ever for Weight Loss
What separates good diets from the best diets? These weight loss strategies--like drink more water, eat breakfast, sleep...
Skinny Sipping: Best and Worst Drinks for Losing Weight in Pictures
From coffee to cocktails, learn which beverages can help or hinder a healthy lifestyle. See the best and worst drinks for weight...
Bad' Foods That Are Good for Weight Loss in Pictures
Some bad foods can be good for weight loss. MedicineNet reveals which tempting foods can actually help you lose weight and keep...
10 Metabolism Boosting Facts and Myths
Losing weight by increasing your metabolism is challenging. There are many metabolism myths and only a few surefire tricks to get...
How to Lose Weight Without Dieting: 24 Fast Facts
Weight loss without dieting? No diet, no problem. Learn the best way to lose weight with these weight loss tips designed to help...
Bikini-Body Pictures: Workout & Beauty Tips for Swimsuit Season
Discover 25 ways to get ready for swimsuit season. See exercises, diet tips, and other healthy beauty fixes that will motivate...
How to Lose Weight Fast: Easy Weight Loss Tips
Here are the best ways for men and women to lose weight. Fast facts from experts show weight loss is possible for everyone trying...
Healthy Dieting Myths and Facts
Learn about healthy dieting myths and facts. Can't tell fact from fiction about weight loss and healthy eating? Discover the...
Low-Carb Snacks in Pictures
Interested in low-carb snacking? Here are some ideas about smart snacks that are filling and low in carbohydrates....
Related Disease Conditions
Obesity is the state of being well above one's normal weight. A person has traditionally been considered to be obese if they are...
Regular physical activity can reduce the risk of disease. Regular exercise can also reduce the symptoms of stress and anxiety....
Fast-food consumption and lack of exercise are just a couple of causes of childhood obesity. Health effects of childhood obesity...
Treatment & Diagnosis
- Childhood Obesity Overweight FAQs
- Food Synergy Secrets for Weight Loss
- Weight Lifting in Weight Loss (Audio Podcast)
- Weight Loss Come to a Halt? Get Unstuck
- Weight Loss Tips to Start Your Diet off Right
- Motivation Along The Weight Loss Path
- Weight Loss Goals: Is Your Goal Realistic?
- Dieter Makeovers: Look Great During Weight Loss
- Weight Loss Wonders & Nutrition Nightmares
- Weight Loss: No diet approach - Audio Newsletter
- Men vs. Women: Weight Loss Wars
- Weight Loss While On Vacation
- Weight Loss Style, What's Yours?
- Obstacles To Weight Loss: What Gets In The Way?
- Protein For Health and Weight Loss
- Weight Loss Program, Almost-Instant Gratification
- Energy Boost: Eat for Energy & Weight Loss
- Calcium Intake Can Enhance Weight Loss
- Weight Loss: Plateau No More
- Weight Loss: Break the Late-Night Eating Habit
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.