- What is loratadine/pseudoephedrine? How does it work (mechanism of action)?
- What is loratadine/pseudoephedrine used for?
- What are the side effects of the combination of loratadine and pseudoephedrine?
- What is the dosage for the combination of loratadine and pseudoephedrine?
- Which drugs or supplements interact with the combination of loratadine and pseudoephedrine?
- Is loratadine and pseudoephedrine safe to take if you are pregnant or breastfeeding?
- What else should you know about loratadine and pseudoephedrine?
What is loratadine/pseudoephedrine? How does it work (mechanism of action)?
- Loratadine/pseudoephedrine is a combination of two drugs, an antihistamine (loratadine) and a decongestant (pseudoephedrine). Loratadine is a long-acting antihistamine that blocks the actions of histamine that causes some of the symptoms of allergic reactions. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that are associated with allergy symptoms. Loratadine blocks one type of histamine receptor (the H1 receptor) and thus prevents activation of cells with H1 receptors by histamine. Unlike some antihistamines, loratadine does not enter the brain from the blood and, therefore, does not cause drowsiness when taken at recommended doses. It is one of a few antihistamines that do not cause sedation. Pseudoephedrine decongests tissues by causing blood vessels to constrict.
- Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour, and many others are brand names for loratadine and pseudoephedrine.
- The combination of loratadine and pseudoephedrine is available in generic form and is available over-the-counter (OTC) without a prescription.
What are the side effects of the combination of loratadine and pseudoephedrine?
Side effects of loratadine/pseudoephedrine include:
What is the dosage for the combination of loratadine and pseudoephedrine?
- Loratadine/pseudoephedrine may be taken with or without food.
- It must be used cautiously in patients with heart (coronary artery) disease and angina (because pseudoephedrine can stimulate the heart) as well as in patients with diabetes (because there is a small chance that pseudoephedrine can raise the level of blood sugar).
- The dose for children older than 12 years and adults is 1 tablet every 12 hours of immediate release tablets or 1 tablet every 24 hours for extended release tablets.
Which drugs or supplements interact with the combination of loratadine and pseudoephedrine?
- Loratadine/pseudoephedrine should not be taken at the same time as or within 14 days of monoamine oxidase inhibitors (MAOIs).
- Erythromycin, cimetidine (Tagamet), itraconazole (Sporanox), and ketoconazole (Nizoral) increase the blood concentration of loratadine by inhibiting the elimination of loratadine. This may result in increased adverse events from loratadine.
- St. John's wort, carbamazepine, and rifampin reduce blood levels of loratadine.
Is loratadine and pseudoephedrine safe to take if you are pregnant or breastfeeding?
What else should you know about loratadine and pseudoephedrine?
What preparations of loratadine and pseudoephedrine are available?
Tablets containing 5 mg loratadine and 120 mg pseudoephedrine (12 hour formulation) and tablets containing 10 mg loratadine and 240 mg pseudoephedrine (24 hour formulation) are available.
How should I keep loratadine and pseudoephedrine stored?
Tablets should be stored at 15 C to 30 C (59 F to 86 F).
Loratadine and pseudoephedrine (Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour, and many others) is a combination of two drugs used to temporarily relieve a runny nose, sneezing, and nasal stuffiness from a common cold. It also is used to relieve nasal and non-nasal symptoms of a variety of allergic conditions like seasonal allergic rhinitis. Side effects, drug interactions, dosing and storage, and pregnancy safety should be reviewed prior to taking this medication.
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Related Disease Conditions
Cough: 19 Tips on How to Stop a Cough
Coughing is a reflex that helps a person clear their airways of irritants. There are many causes of an excessive or severe cough including irritants like cigarette and secondhand smoke, pollution, air fresheners, medications like beta blockers and ACE inhibitors, the common cold, GERD, lung cancer, and heart disease.Natural and home remedies to help cure and soothe a cough include staying hydrated, gargle salt water, use cough drops or lozenges, use herbs and supplements like ginger, mint, licorice, and slippery elm, and don't smoke. Over-the-counter products (OTC)to cure and soothe a cough include cough suppressants and expectorants, and anti-reflux drugs. Prescription drugs that help cure a cough include narcotic medications, antibiotics, inhaled steroids, and anti-reflux drugs like proton pump inhibitors or PPIs, for example, omeprazole (Prilosec), rabeprazole (Aciphex), and pantoprazole (Protonix).
What Is Mucus?
Mucus is a normal substance produced by lining tissues in the body. Excess mucus or mucus that is yellow, green, brown, or bloody may indicate a problem. Mucus production may increase when allergies, a cold, flu, cough, or sore throat are present. Antihistamines and cold and flu medications may help alleviate excess mucus. A neti pot may be used to decrease nasal congestion and clear mucus.
Sinus Infection (Sinusitis)
Sinus infection (sinusitis) is caused by allergies, infection, and chemicals or other irritants of sinuses. Signs and symptoms include headache, fever, and facial tenderness, pressure, or pain. Treatments of sinus infections are generally with antibiotics and at times, home remedies.
The common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and maybe a fever. Antibiotics have no effect upon the common cold, and there is no evidence that zinc and vitamin C are effective treatments.
Sore throat (throat pain) usually is described as pain or discomfort in the throat area. A sore throat may be caused by bacterial infections, viral infections, toxins, irritants, trauma, or injury to the throat area. Common symptoms of a sore throat include a fever, cough, runny nose, hoarseness, earaches, sneezing, and body aches. Home remedies for a sore throat include warm soothing liquids and throat lozenges. OTC remedies for a sore throat include OTC pain relievers such as ibuprofen or acetaminophen. Antibiotics may be necessary for some cases of sore throat.
How Long Does an Allergic Reaction Last?
Allergic reactions may last for varying lengths of time. They may take a few hours to a few days to disappear. If the exposure to the allergen continues, such as during a spring pollen season, allergic reactions may last for longer periods such as a few weeks to months.
Pink Eye (Conjunctivitis)
Pinkeye, also called conjunctivitis, is redness or irritation of the conjunctivae, the membranes on the inner part of the eyelids and the membranes covering the whites of the eyes. These membranes react to a wide range of bacteria, viruses, allergy-provoking agents, irritants, and toxic agents.
Hives, also called urticaria, is a raised, itchy area of skin. Most often the cause of hives is unknown. Sometimes it is a sign of an allergic reaction to food or medications, but the cause of the allergy (the allergen) is unknown. Dermatographism and swelling (angioedema) may accompany hives. Treatment to get rid of hives and alleviate symptoms typically includes antihistamines.
An allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is short in duration (10-20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
Sinus headache is caused by a sinus infection or inflammation of the sinus cavities. Symptoms of a sinus headache include pain, runny or stuffy nose, and chronic cough. There are many causes of sinus headaches including sinusitis or sinus infection, allergies, smoke, infections, or colds. Treatment for sinus headache depends on the cause. Some home remedies may relieve sinus headache pain symptoms.
Hay Fever (Allergic Rhinitis)
Hay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic symptoms: nasal congestion, runny nose, sneezing, eye and nose itching, and tearing eyes. Avoidance of known allergens is the recommended treatment, but if this is not possible, antihistamines, decongestants, and nasal sprays may help alleviate symptoms.
Do Allergy Desensitization Shots Work?
Allergies happen when your immune system overreacts to harmless substances called allergens. Allergy desensitization shots make your body less likely to react to allergen.
Sinus Infection vs. Allergies
Both sinus infections and allergies (allergic rhinitis) cause symptoms such as runny or stuffy nose and fatigue. Sinus infection (known as sinusitis) is inflammation of the sinuses, caused by infection from bacteria, viruses, and/or fungi (molds). Allergic rhinitis occurs when certain allergies cause nasal symptoms. When a person with allergies breathes in an allergen, such as pollen, dust, or animal dander, symptoms such as runny or stuffy nose, itching, sneezing, and fatigue occur.
Can Hot Weather Cause Sinus Problems?
Sinusitis is a condition where you experience irritation and swelling of your sinuses. Allergies and sinus problems are common during the warmer seasons.
How to Get Rid of a Sinus Infection Fast
The sinuses are air-filled cavities that surround the nose and drain into the nose. They are present in the forehead, the cheeks and near the eyes. Treatment for sinus infections includes over-the-counter pain relievers, decongestants, antibiotics, humidifiers, nasal irrigation, steam inhalation, rest, hydration and warm compresses.
Why Won’t My Allergy Symptoms Go Away?
Allergies happen when your body's immune system reacts to certain substances as though they are harmful. Allergy symptoms may not go away unless you avoid your triggers, stick to your medications, find the right combination of medications, and consider surgery.
What Is the Best Treatment for a Jellyfish Sting?
Jellyfish are the most common creatures found in seawater around the world. Jellyfish tentacles have stinging cells called nematocysts that secrete a poisonous substance (venom). The best treatment for jellyfish stings includes rinsing the area with water or vinegar, removing the tentacles, soaking the affected area in hot water, taking medications to ease itching and pain and seeking medical attention, if necessary.
How Do You Know if You Are Allergic to Pollen?
Pollen is a powdery yellow grain that fertilizes other plants of the same species. The only way to know for sure if a person has pollen allergy is to see a board-certified allergist for allergy testing.
What Are the Symptoms of Ragweed Allergy?
The common symptoms of ragweed allergy are sneezing, runny nose, itchy, watery red eyes, headache, nasal congestion, eye swelling, rashes and coughing.
Should I Exercise Outside if I Have Allergies?
An allergy is a condition in which the immune system overresponds to a foreign substance. With the right treatment and precautions, you can completely eliminate allergy flare-ups during your outdoor workout.
Treatment & Diagnosis
- Cold & Flu FAQs
- Common Cold FAQs
- Bronchitis FAQs
- Drugs: Buying Prescription Drugs Online Safely
- Asthma Rates Increasing
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- OTC Cold and Cough Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- Antihistamines (Oral)
- Side Effects of Sudafed (pseudoephedrine)
- Side Effects of Claritin (loratadine)
- loratadine, Claritin, Claritin RediTabs, Alavert, Claritin Hives Relief, Children's Claritin
- Side Effects of Claritin D (loratadine/pseudoephedrine)
- fexofenadine (Allegra, Mucinex Allergy)
- fexofenadine and pseudoephedrine (Allegra-D)
- Xyzal (levocetirizine dihydrochloride)
- Dymista (azelastine hydrochloride and fluticasone propionate)
- Beconase AQ (beclomethasone) Side Effects, Warnings, and Drug Interactions
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information.