- Related Diseases
- Images & Quizzes
- 10 Common Allergy Triggers Slideshow Pictures
- Take the Quiz on Allergies
- Nasal Allergy Relief Products Slideshow
- What is loratadine and pseudoephedrine, and how does it work (mechanism of action)?
- What brand names are available for loratadine and pseudoephedrine?
- Is loratadine and pseudoephedrine available as a generic drug?
- Do I need a prescription for loratadine and pseudoephedrine?
- What are the side effects of loratadine and pseudoephedrine?
- What is the dosage for loratadine and pseudoephedrine?
- Which drugs or supplements interact with loratadine and pseudoephedrine?
- Is loratadine and pseudoephedrine safe to take if I'm pregnant or breastfeeding?
- What else should I know about loratadine and pseudoephedrine?
What is loratadine and pseudoephedrine, and how does it work (mechanism of action)?
Loratadine/pseudoephedrine is a combination of two drugs, an antihistamine (loratadine) and a decongestant (pseudoephedrine). Loratadine is a long-acting antihistamine that blocks the actions of histamine that causes some of the symptoms of allergic reactions. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that are associated with allergy symptoms. Loratadine blocks one type of histamine receptor (the H1 receptor) and thus prevents activation of cells with H1 receptors by histamine. Unlike some antihistamines, loratadine does not enter the brain from the blood and, therefore, does not cause drowsiness when taken at recommended doses. It is one of a few antihistamines that do not cause sedation. Pseudoephedrine decongests tissues by causing blood vessels to constrict.
What brand names are available for loratadine and pseudoephedrine?
Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour, and many others
What are the side effects of loratadine and pseudoephedrine?
Side effects of loratadine/pseudoephedrine include:
Quick GuideBad Bugs: Identify Bug Bites From Mosquitos, Spiders and More
What is the dosage for loratadine and pseudoephedrine?
- Loratadine/pseudoephedrine may be taken with or without food.
- It must be used cautiously in patients with heart (coronary artery) disease and angina (because pseudoephedrine can stimulate the heart) as well as in patients with diabetes (because there is a small chance that pseudoephedrine can raise the level of blood sugar).
- The dose for children older than 12 years and adults is 1 tablet every 12 hours of immediate release tablets or 1 tablet every 24 hours for extended release tablets.
Which drugs or supplements interact with loratadine and pseudoephedrine?
- Loratadine/pseudoephedrine should not be taken at the same time as or within 14 days of monoamine oxidase inhibitors (MAOIs).
- Erythromycin, cimetidine (Tagamet), itraconazole (Sporanox), and ketoconazole (Nizoral) increase the blood concentration of loratadine by inhibiting the elimination of loratadine. This may result in increased adverse events from loratadine.
- St. John's wort, carbamazepine, and rifampin reduce blood levels of loratadine.
Is loratadine and pseudoephedrine safe to take if I'm pregnant or breastfeeding?
What else should I know about loratadine and pseudoephedrine?
What preparations of loratadine and pseudoephedrine are available?
Tablets containing 5 mg loratadine and 120 mg pseudoephedrine (12 hour formulation) and tablets containing 10 mg loratadine and 240 mg pseudoephedrine (24 hour formulation) are available.
How should I keep loratadine and pseudoephedrine stored?
Tablets should be stored at 15 C to 30 C (59 F to 86 F).
Medically reviewed by Eni Williams; PharmD., Ph.D.
FDA Prescribing Information
Quick GuideBad Bugs: Identify Bug Bites From Mosquitos, Spiders and More
Daily Health News
Subscribe to MedicineNet's Allergy and Asthma Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
- loratadine and pseudoephedrine (Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour) Related Diseases
- loratadine and pseudoephedrine (Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour) Images & Quizzes
- loratadine and pseudoephedrine (Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour) Index
FDA Prescribing Information
Top loratadine and pseudoephedrine Related ArticlesComplete List
Know Your Allergy TriggersAllergies are an overreaction of the immune system where the body's defenses react to substances such as pollen, food and more. Learn about common allergy triggers and how you can avoid an allergy attack.
AllergyAn allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is is short in duration (10 to 20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include
- nasal congestion,
- sore throat,
- muscle aches, and
Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
Bronchitis QuizWhat happens within the body when a person develops bronchitis? Take this quick quiz to learn the causes, symptoms, treatments, and complications of this common respiratory illness.
Cold & Flu QuizAches? Pain? Fever? This Cold & Flu Quiz tests your knowledge on the difference between coming down with the common cold and sickness from influenza virus.
Common ColdThe common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and maybe a fever. Antibiotics have no effect upon the common cold, and there is no evidence that zinc and vitamin C are effective treatments.
Cold Prevention SlidesThe common cold is arguably the most common human illness. Learn how long the common cold lasts, treatment for the common cold and ways to prevent it.
Common Cold QuizTake this quiz to learn the truth behind the infectious, contagious, uncomfortable disease known as the common cold. Test your knowledge of colds; get prevention tips, and learn what you may want to avoid when treating a cold!
Hay FeverHay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic symptoms: nasal congestion, runny nose, sneezing, eye and nose itching, and tearing eyes. Avoidance of known allergens is the recommended treatment, but if this is not possible, antihistamines, decongestants, and nasal sprays may help alleviate symptoms.
HivesHives, also called urticaria, is a raised, itchy area of skin that is usually a sign of an allergic reaction. The allergy may be to food or medications, but usually the cause of the allergy (the allergen) is unknown.
Allergy-Proof Your HomeTake this home allergy quiz and test your knowledge on allergens, dust mites, pollens and more to see how allergy-proof your home is.
Natural Cold & Flu RemediesWhat natural remedies work for the flu and common cold? Many claim cold symptoms and flu symptoms can be relieved with Echinacea, zinc, neti pots, garlic, vitamin C, saltwater gargles, nasal strips, or bed rest. Find out what cold and flu treatments work the natural way, and what doesn't.
Pink EyePinkeye, also called conjunctivitis, is redness or irritation of the conjunctivae, the membranes on the inner part of the eyelids and the membranes covering the whites of the eyes. These membranes react to a wide range of bacteria, viruses, allergy-provoking agents, irritants, and toxic agents.
Sinus HeadacheSinus headache is caused by a sinus infection or inflammation of the sinus cavities. Symptoms of a sinus headache include pain, runny or stuffy nose, and chronic cough. There are many causes of sinus headaches including sinusitis or sinus infection, allergies, smoke, infections, or colds. Treatment for sinus headache depends on the cause. Some home remedies may relieve sinus headache pain symptoms.
Sinuses PictureThe sinuses are an air-filled cavity in a dense portion of a skull bone. See a picture of the Sinuses and learn more about the health topic.
SinusitisSinus infection (sinusitis) is caused by allergies, infection, and chemicals or other irritants of sinuses. Signs and symptoms are headache, fever, and facial tenderness, pressure, or pain. Treatments of sinus infections are generally with antibiotics and at times, home remedies.
Sore Throat (Pharyngitis)Sore throats are generally described as pain or discomfort in the throat area. A sore throat may be caused by:
- bacterial infections,
- viral infections,
- trauma, or
- injury to the throat area.
What Is MucusMucus is a normal substance produced by lining tissues in the body. Excess mucus or mucus that is yellow, green, brown, or bloody may indicate a problem. Mucus production may increase when allergies, a cold, flu, cough, or sore throat are present. Antihistamines and cold and flu medications may help alleviate excess mucus. A neti pot may be used to decrease nasal congestion and clear mucus.