loratadine, Claritin, Claritin RediTabs, Alavert, Claritin Hives Relief, Children's Claritin

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical and Pharmacy Editor: William C. Shiel Jr., MD, FACP, FACR
    William C. Shiel Jr., MD, FACP, FACR

    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

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What is loratadine, and how does it work (mechanism of action)?

Loratadine is a long-acting, non-sedating antihistamine that is used for the treatment of allergies. Histamine is a chemical that causes many of the signs and symptoms of an allergy. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine on their surfaces. Histamine stimulates the cells to release chemicals that produce effects that we associate with allergy, including welts, itching, and tissue swelling. Loratadine blocks one type of histamine receptor (the H1 receptor) and thus prevents activation of cells with H1 receptors by histamine. Unlike some antihistamines, loratadine does not enter the brain from the blood and, therefore, does not cause drowsiness when taken at recommended doses. The FDA approved loratadine in April 1993.

What brand names are available for loratadine?

Claritin, Claritin RediTabs, Alavert, Claritin Hives Relief, Children's Claritin, and others

Is loratadine available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for loratadine?

No

What are the uses for loratadine?

What are the side effects of loratadine?

The most common adverse events with loratadine are:

Nervousness and difficulty sleeping have also been reported.

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What is the dosage for loratadine?

The usual dose of loratadine is 10 mg daily for adults and children older than six years of age. The dose for children 2 to 6 years of age is 5 mg daily.

Which drugs or supplements interact with loratadine?

: Erythromycin, cimetidine (Tagamet), and ketoconazole (Nizoral) increase the blood concentration of loratadine by inhibiting the elimination of loratadine. This may result in increased adverse events from loratadine.

St. John's wort, carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol, Epitol, Teril), and rifampin reduce blood levels of loratadine.

Is loratadine safe to take if I'm pregnant or breastfeeding?

Loratadine is secreted in breast milk at levels similar to blood levels. Nursing mothers should decide whether to stop breastfeeding or discontinue loratadine.

What else should I know about loratadine?

What preparations of loratadine are available?

  • Tablets: 10 mg.
  • Tablets, disintegrating: 5 and 10 mg.
  • Tablets, chewable: 5 mg.
  • Syrup: 5 mg/5 ml.

How should I keep loratadine stored?

Tablets should be stored between 2 C and 30 C (36 F and 86 F), and syrup should be stored between 2 C and 25 C (36 and 77 F).

Reference: FDA Prescribing Information

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See more info: loratadine on RxList
Reviewed on 8/24/2015
References
Reference: FDA Prescribing Information

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