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- What is loracarbef, and how does it work (mechanism of action)?
- What brand names are available for loracarbef?
- Is loracarbef available as a generic drug?
- Do I need a prescription for loracarbef?
- What are the side effects of loracarbef?
- What is the dosage for loracarbef?
- Which drugs or supplements interact with loracarbef?
- Is loracarbef safe to take if I'm pregnant or breastfeeding?
- What else should I know about loracarbef?
What is loracarbef, and how does it work (mechanism of action)?
Loracarbef is a synthetic oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes cephalexin (Keflex), cefaclor (Ceclor), cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and many injectable antibiotics. Like other cephalosporins, loracarbef stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall. Loracarbef is effective against a wide variety of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, E. coli, and many others. Loracarbef was approved in December 1991.
What brand names are available for loracarbef?
(Lorabid: This brand no longer is available in the U.S. and there are no generic formulations.)
What are the side effects of loracarbef?
Loracarbef is generally well tolerated, and side effects are usually transient. More common side effects include nausea, abdominal pain, vomiting, skin rash, abnormal liver tests, vaginitis, itching, headaches, and dizziness.
Loracarbef should be avoided by patients with a known allergy to other cephalosporin antibiotics. Since loracarbef is chemically related to penicillin, an occasional patient can have an allergic reaction (sometimes even life threatening anaphylaxis) to both medications. Treatment with loracarbef and other antibiotics can alter the normal bacteria flora of the colon and permit overgrowth of the bacterium, Clostridium difficile, in the colon. This may lead to inflammation of the colon known as C. difficile or pseudo-membranous colitis. Patients who develop pseudo-membranous colitis as a result of antibiotic treatment can experience diarrhea, abdominal pain, fever, and sometimes even shock.
Which drugs or supplements interact with loracarbef?
Probenecid (Benemid) may increase the concentration of loracarbef in the blood by decreasing excretion of loracarbef by the kidney. This interaction is sometimes used to enhance the effect of cephalosporins.
Is loracarbef safe to take if I'm pregnant or breastfeeding?
Safe use during pregnancy has not been established.
Safe use in nursing mothers has not been established.
What else should I know about loracarbef?
What preparations of loracarbef are available?
Capsules: 200 and 400 mg. Suspension: 100 and 200 mg/5 ml.
How should I keep loracarbef stored?
Tablets and oral suspension may be stored at room temperature, 15 C to 30 C (59 F to 86 F) in a tightly closed container.
Loracarbef (Lorabid) is an oral antibiotic prescribed for the treatment of bacterial infections such as middle ear, tonsillitis, sore throat, laryngitis, bronchitis, sinusitis, and pneumonia. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking any medication.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Reference: FDA Prescribing Information