- What is lisinopril and hydrochlorothiazide, and how does it work (mechanism of action)?
- What brand names are available for lisinopril and hydrochlorothiazide?
- Is lisinopril and hydrochlorothiazide available as a generic drug?
- Do I need a prescription for lisinopril and hydrochlorothiazide?
- What are the side effects of lisinopril and hydrochlorothiazide?
- What is the dosage for lisinopril and hydrochlorothiazide?
- Which drugs or supplements interact with lisinopril and hydrochlorothiazide?
- Is lisinopril and hydrochlorothiazide safe to take if I'm pregnant or breastfeeding?
- What else should I know about lisinopril and hydrochlorothiazide?
What is lisinopril and hydrochlorothiazide, and how does it work (mechanism of action)?
Zestoretic and Prinzide are combinations of two drugs, lisinopril and hydrochlorothiazide which are used for treating high blood pressure.
What is the dosage for lisinopril and hydrochlorothiazide?
The dose of Zestoretic or Prinzide is tailored to the patient's individual need, based on each component of the medication.
Which drugs or supplements interact with lisinopril and hydrochlorothiazide?
Please read the lisinopril and hydrochlorothiazide articles.
Is lisinopril and hydrochlorothiazide safe to take if I'm pregnant or breastfeeding?
Please read the lisinopril and hydrochlorothiazide articles. Please read the lisinopril and hydrochlorothiazide articles.
What else should I know about lisinopril and hydrochlorothiazide?
What preparations of lisinopril and hydrochlorothiazide are available?
Tablets: 12.5/10, 12.5/20, and 25/20 mg hydrochlorothiazide/mg lisinopril.
How should I keep lisinopril and hydrochlorothiazide stored?
Zestoretic and Prinzide should be stored at 59 F to 86 F (15 C to 30 C) and protected from excessive light and humidity.
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Lisinopril and hydrochlorothiazide (Zestoretic, Prinzide) is a combination of two drugs, lisinopril and hydrochlorothiazide, and is prescribed to treat hypertension (high blood pressure). Side effects, drug interactions, and pregnancy information should be reviewed prior to taking this medication.
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Related Disease Conditions
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Kidney (Renal) Failure
Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss, dehydration, or medication. Some of the renal causes of kidney failure include sepsis, medications, rhabdomyolysis, multiple myeloma, and acute glomerulonephritis. Post renal causes of kidney failure include bladder obstruction, prostate problems, tumors, or kidney stones.Treatment options included diet, medications, or dialysis.
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Chronic cough is a cough that does not go away and is generally a symptom of another disorder such as asthma, allergic rhinitis, sinus infection, cigarette smoking, GERD, postnasal drip, bronchitis, pneumonia, medications, and less frequently tumors or other lung disease. Chronic cough treatment is based on the cause, but may be soothed natural and home remedies.
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is short in duration (10-20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
Heart Attack (Myocardial Infarction)
A heart attack occurs when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. Learn about warning signs, causes, complications, risk factors, and treatment.
Things to Know About High Blood Pressure Treatment
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least 3 months, 2 years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
Whooping Cough (Pertussis)
Whooping cough (pertussis) is a highly contagious respiratory infection caused by the bacteria Bordetella pertussis. There are an estimated 300,000 plus deaths annually from whooping cough (pertussis). Whooping cough commonly affects infants and young children but can be prevented with immunization with the vaccine. First stage whooping cough symptoms are a runny nose, sneezing, low-grade fever, a mild cough with the cough gradually becoming more severe. After one to two weeks, the second stage of whooping cough begins.
Children's Cough Causes and Treatments
Children's cough causes include infection, acid reflux, asthma, allergies or sinus infection, whooping cough, and exposure to irritants. Treatment for a child's cough include cough medicine for children over the age of four.
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management. Symptoms of heart attack in men and women include chest discomfort and pain in the shoulder, neck, jaw, stomach, or back.
Emphysema, Chronic Bronchitis, and Colds
If you have a COPD such as emphysema, avoiding chronic bronchitis and colds is important to avoid a more severe respiratory infection such as pneumonia. Avoiding cigarette smoking, practice good hygeine, stay away from crowds, and alerting your healthcare provider if you have a sinus infection or cold or cough that becomes worse. Treatment options depend upon the severity of the emphysema, bronchitis, or cold combination.
Treatment & Diagnosis
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Medications & Supplements
- ACE Inhibitors
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- lisinopril (Zestril, Prinivil, Qbrelis) ACE Inhibitor
- ramipril (Altace)
- trandolapril (Mavik)
- benazepril (Lotensin HTC)
- captopril (Capoten)
- enalapril (Vasotec, Epaned)
- Side Effects of Zestoretic (lisinopril and hydrochlorothiazide)
- quinapril (Accupril)
- benazepril and hydrochlorothiazide (Lotensin HCT)
- fosinopril sodium, Monopril
- captopril and hydrochlorothiazide (Capozide)
- enalapril and hydrochlorothiazide (Vaseretic)
Prevention & Wellness
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.