- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
- What is lisinopril, and how does it work (mechanism of action)?
- What are the side effects of lisinopril?
- Why does lisinpril cause a cough?
- What is the dosage of lisinopril, and how should I take it?
- Which drugs or supplements interact with medication?
- What brand names are available for lisinopril?
- Is lisinopril available as a generic drug?
- Do I need a prescription for this medication?
- Is this drug safe to take if I'm pregnant or breastfeeding?
- What else should I know about this medicaiton?
What is lisinopril, and how does it work (mechanism of action)?
Lisinopril is an angiotensin converting enzyme (ACE) inhibitor used for treating high blood pressure, heart failure and for preventing kidney failure due to high blood pressure and diabetes. Other ACE inhibitors include:
- enalapril (Vasotec)
- quinapril (Accupril)
- captopril (Capoten)
- fosinopril (Monopril)
- benazepril (Lotensin)
- ramipril (Altace)
- moexipril (Univasc)
- trandolapril (Mavik)
ACE is important because it is an enzyme responsible for producing the chemical, angiotensin II. Angiotensin II causes muscles in most arteries, including the arteries of the heart, to contract, thereby narrowing the arteries and elevating blood pressure. ACE inhibitors such as lisinopril lower blood pressure by reducing the production of angiotensin II, thereby relaxing arterial muscle and enlarging arteries. When the blood pressure is lower, the heart - including the failing heart - does not have to work as hard to pump blood. The arteries supplying the heart with blood also enlarge during treatment with ACE inhibitors. This increases the flow of blood and oxygen to the heart, further improving the ability of the heart to pump blood.
The effects of ACE inhibitors are particularly beneficial to people with congestive heart failure. In the kidneys, the narrowing of the arteries by angiotensin II decreases blood flow and damages the kidneys. ACE inhibitors enlarge and reduce the blood pressure in the arteries going to the kidney. This reduces damage to the kidneys caused by the high blood pressure. The FDA approved lisinopril in December 1987.
What are the side effects of lisinopril?
First doses of lisinopril can cause dizziness due to a drop in blood pressure.
This drug also can cause:
Like all ACE inhibitors, lisinopril may cause a nonproductive cough that resolves when the drug is discontinued.
Lisinopril should be stopped if there are symptoms or signs of an allergic reaction including feelings of swelling of the face, lips, tongue or throat. Severe allergic reactions (anaphylaxis) and hives occasionally occur.
What is the dosage of lisinopril, and how should I take it?
- The starting dose of lisinopril for treating heart failure is 5 mg daily, and the effective dose range for treating heart failure is 5-40 mg daily. The dose can be increased by 10 mg every 2 weeks to achieve the maximum effect.
- The starting dose of lisinopril for treating high blood pressure is 10 mg daily. The usual dose range is 20-40 mg daily. A dose of 80 mg is not much more effective than 40 mg.
- Treatment of heart attack is started with an initial dose of 5 mg followed by 5 mg after 24 hours, 10 mg after 48 hours, and then 10 mg daily. Treatment is continued for 6 weeks.
Which drugs or supplements interact with medication?
In general, lisinopril should not be taken with potassium supplements or diuretics that conserve potassium, for example, hydrochlorothiazide/triamterene (Dyazide), since blood potassium levels may rise to dangerous levels.
There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, and many others), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors.
Nitritoid reactions (symptoms of facial flushing, nausea, vomiting and hypotension) may occur when injectable gold sodium aurothiomalate used in the treatment of rheumatoid arthritis, is combined with ACE inhibitors, including lisinopril.
What brand names are available for lisinopril?
Zestril, Prinivil, and Qbrelis are the brand names available for this drug.
Is this drug safe to take if I'm pregnant or breastfeeding?
What else should I know about this medicaiton?
What preparations of lisinopril are available?
Tablet: 2.5, 5, 10, 20, 30 and 40 mg
How should I keep lisinopril stored?
Lisinopril should be stored in a dry place at 15 C to 30 C (59 F to 86 F).
Lisinopril (Zestril, Prinivil, Qbrelis) is an ACE inhibitor prescribed for the treatment of:
- High blood pressure
- Heart failure
- Heart attack survival
- Preventing kidney failure due to high blood pressure
Side effects are, nasal congestion, anxiety, headaches, insomnia, drowsiness, and nausea. ACE inhibitors may cause a nonproductive cough that resolves once you stop taking the drug. Drug interactions include potassium supplements or derivatives of potassium, lithium (Eskalith, Lithobid), nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen), and symptoms of flushing; high blood pressure; nausea; and vomiting. Warnings and precautions, pregnancy information, and other safety information should be reviewed prior to taking any medication.
If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Multimedia: Slideshows, Images & Quizzes
High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes
Take this quiz and test your IQ of high blood pressure (hypertension), the cardiovascular disease that causes most strokes and...
Diabetes Quiz: Test Your Medical IQ
Take the Diabetes Quiz and learn the causes, signs, symptoms, and types of this growing epidemic. What does diabetes have to do...
Kidney Disease Quiz: Test Your Medical IQ
Kidney disease is common. Take this kidney disease quiz to test your knowledge and learn the symptoms, causes and types of kidney...
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Picture of Hypertension
High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140...
Picture of Heart Detail
The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an...
Picture of Heart
The muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more...
Heart Disease: Symptoms, Signs, and Causes
What is heart disease (coronary artery disease)? Learn about the causes of heart disease. Symptoms of heart disease include chest...
Salt Shockers: Where High-Sodium Foods Lurk, and How to Avoid Them
Salty Foods can be everywhere. So how can you maintain a low-sodium diet and beware of the risks of high blood pressure which can...
Type 2 Diabetes Diagnosis, Treatment, Medication
Learn about type 2 diabetes warning signs, symptoms, diagnosis, and treatment options. Read how diet and exercise can help manage...
Pictures of Famous People With Diabetes
See pictures of celebrities that have been diagnosed with type 1 or type 2 diabetes including Mary Tyler Moore, Salma Hayek, and...
Heart-Healthy Diet: 25 Foods to Protect Your Cardiovascular System
See 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and...
Heart Disease: Causes of a Heart Attack
Learn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease...
The Benefits of Omega 3 Foods on Heart Health
What are the benefits of omega 3 fatty acids? Learn how Omega 3 rich foods like fish oil, salmon, walnuts, & more can boost brain...
Am I Having a Heart Attack? Symptoms of Heart Disease
Heart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs...
High Blood Pressure (Hypertension): Symptoms, Causes, Treatments
What causes high blood pressure (hypertension)? Know the warning signs and symptoms of high blood pressure. Read about high blood...
Type 1 Diabetes: What Are The Symptoms?
What is type 1 diabetes? Is there a cure for type 1 diabetes? Learn about type 1 diabetes symptoms, warning signs, causes, and...
Diabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating
Discover the best and worst meals for diabetes-savvy dining. See how to avoid carbs and control your blood sugar with healthier...
Blood Sugar Swings: Tips for Managing Diabetes & Glucose Levels
Learn to better control your glucose levels by preventing blood sugar swings. Beware of caffeine, sugary foods, spices, exercise,...
Diabetes Management Tips and Preventing Complications
Learn 10 simple ways to better manage your diabetes. See tips for controlling blood sugar, diet and exercise and other helpful...
Pictures of 10 Muscle-Building Exercises for Diabetes
Watch this slideshow on Diabetes and Exercise. If you have diabetes, see how strengthening your muscles with these 10 weight...
High-Fiber Super Foods: Whole Grains, Fruits, & More
Learn about high-fiber foods. From fresh fruits to whole grains, these fiber-rich foods can lower cholesterol, prevent...
Heart Health Pictures: How to Lower Triglycerides
Learn 14 ways to lower triglycerides. Learn to keep your heart healthy and triglyceride levels in check with these diet,...
Food Swaps for Meals and Snacks for Heart Health in Pictures
Explore 10 food swaps for heart-wise dining. Learn what food to buy and how to cook in order to make a big difference for your...
Related Disease Conditions
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are...
High Blood Pressure (Hypertension) Signs, Causes, Diet, and Treatment
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million...
A heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart...
Scleroderma is an autoimmune disease of the connective tissue. It is characterized by the formation of scar tissue (fibrosis) in...
12 Congestive Heart Failure Symptoms, Stages, Causes, and Life Expectancy
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease,...
Cough (Chronic, Persistent Cough in Adults and Children)
Chronic cough is a cough that does not go away and is generally a symptom of another disorder such as asthma, allergic...
Pregnancy and Drugs (Prescription and OTC)
Taking prescription medications or over-the-counter drugs or supplements should be discussed with your doctor. There are some...
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management....
Kidney Failure (Symptoms, Signs, Stages, Causes, and Treatment)
Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss,...
12 Heart Attack Symptoms and Early Warning Signs
Recognizing heart attack symptoms and signs can help save your life or that of someone you love. Some heart attack symptoms,...
Heart Attack Pathology: Photo Essay
A heart attack is a layperson's term for a sudden blockage of a coronary artery. This photo essay includes graphics, pictures,...
Omega-3 Fatty Acids (Benefits, Uses, Foods)
Omega-3 fatty acids are essential fats that help decrease one's cholesterol and triglyceride levels as well as reduce the risk of...
Hypertensive Kidney Disease
High blood pressure can damage the kidneys and is one of the leading causes of kidney failure (end-stage renal kidney disease)....
Heart failure (congestive) is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and...
Stress and Heart Disease
The connection between stress and heart disease is not clear. Stress itself may be a risk factor, or high levels of stress may...
How the Heart Works
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood...
Vitamins & Exercise: Heart Attack Prevention Series
Vitamins and exercise can lower your risk for heart attack and heart disease. Folic acid, vitamins, and homocysteine levels are...
Diabetes Treatment (Type 1 and Type 2 Medications and Diet)
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar....
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include...
Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to...
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to...
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile...
Diabetes and Kidney Disease
In the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose...
Heart Attacks in Women
Heart disease, particularly coronary artery disease is the leading cause of heart attacks. Women are more likely to die from a...
Smoking and Heart Disease
Smoking increases the risk of heart disease in women and men. Nicotine in cigarettes decrease oxygen to the heart, increases...
Heart Disease in Women
Heart disease in women has somewhat different symptoms, risk factors, and treatment compared to heart disease in men. Many women...
Heart Disease Treatment in Women
Heart disease treatment in women should take into account female-specific guidelines that were developed by the American Heart...
Heart Attack Prevention Overview
Heart attacks are the major causes of unexpected, sudden death among men and women. A heart attack also is a significant cause...
Treatment & Diagnosis
- High Blood Pressure FAQs
- Heart Disease FAQs
- Diabetes FAQs
- Kidney Disease FAQs
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- quinapril, Accupril
- ramipril, Altace
- captopril, Capoten
- benazepril (Lotensin HTC)
- fosinopril sodium, Monopril
- enalapril, Vasotec, Epaned
- lisinopril and hydrochlorothiazide, Zestoretic, Prinzide
- benazepril and hydrochlorothiazide, Lotensin HCT
- enalapril and hydrochlorothiazide, Vaseretic
- captopril and hydrochlorothiazide, Capozide
- trandolapril, Mavik
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- ACE Inhibitors (Side Effects, List of Names, Uses, and Dosage)
- Drug Interactions
- High Blood Pressure Drugs (Hypertension)
- Congestive Heart Failure Medications
- Vasodilators (Drug Class Side Effects, List of Names)
Prevention & Wellness
- Bonus From Your Blood Pressure Med: Fewer Fractures?
- Prices of Generic Heart Failure Drugs Vary Widely
- Device Plus 'Aggressive' Drug Strategy May Curb Severe Heart Failure
- Prescription Drug Use on the Rise in U.S.
- Study Finds Two Drugs Aren't Better Than One for Kidney Disease
- Certain Allergies Plus Blood Pressure Meds Could Be Bad Mix
- Model Program Boosts Blood-Pressure Control for Patients
- Common Blood Pressure Drugs May Help Slow Dementia
- Drugs Can Sometimes Prevent Migraines, but at a Cost
- Blood Pressure Drugs Linked to Lip Cancer in Study
- The 10 Most Prescribed Drugs
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.