Vyvanse (lisdexamfetamine)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

ADHD Symptoms in Children

What brand names are available for lisdexamfetamine?

Vyvanse

Is lisdexamfetamine available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for lisdexamfetamine?

Yes

What are the uses for lisdexamfetamine?

What are the side effects of lisdexamfetamine?

Common side effects of Vyvanse include:

Other important side effects of Vyvanse include:

Increased blood pressure, sudden death in patients with heart problems, strokes, and heart attacks have been associated with Vyvanse. Patients may experience new or worsening of psychiatric symptoms (for example, manic episodes, hearing voices, hallucinations) or worsening of aggressive behavior or hostility.

Vyvanse like other amphetamines may be abused. Amphetamines have been associated with tolerance, psychological dependence, and social disability. Stopping amphetamines suddenly may cause a withdrawal syndrome that includes extreme fatigue and mental depression. Therefore, there use should be discontinued by slowly reducing the dose.

Priapism defined as painful and nonpainful penile erection lasting more than 4 hours, have been reported in pediatric and adult patients treated with stimulants. The erection usually resolves when the drug is stopped. Prompt medical attention is required in the event of suspected priapism.

Quick GuideADHD Symptoms in Children

ADHD Symptoms in Children

What is the dosage for lisdexamfetamine?

  • The recommended starting dose of Vyvanse for treating ADHD in adults is 30 mg and for pediatric patients ages (6-12) it is 20 to 30 mg once daily in the morning. Doses may be increased by 10-20 mg/day at weekly intervals. The maximum dose is 70 mg daily.
  • The recommended dose for treating binge eating in adult is 50 to 70 mg daily. The starting dose is 30 mg/day and the dose is gradually increased by 20 mg at weekly intervals to reach the recommended daily dose.

Which drugs or supplements interact with lisdexamfetamine?

  • Monoamine oxidase inhibitor (MAOIs) antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl) and procarbazine (Matulane), slow the elimination of amphetamines in the body. This increases the concentration of amphetamines and their effect. This can cause serious elevations in blood pressure (hypertensive crisis) with headaches, other signs of hypertensive crisis, and even fatal reactions. Vyvanse should not be administered until 14 days after MAOIs have been discontinued in order to allow the effects of the MAOIs to dissipate.
  • Amphetamines increase the effect of norepinephrine. Combining both drugs may lead to serious cardiovascular toxicity.

Is lisdexamfetamine safe to take if I'm pregnant or breastfeeding?

  • There are no adequate studies of Vyvanse in pregnant women. Amphetamines may cause premature delivery, low birth weight, and withdrawal symptoms in infants born to mothers who are dependent on amphetamines.
  • Amphetamines are excreted in breast milk. Mothers taking amphetamines should not breastfeed.

What else should I know about lisdexamfetamine?

What preparations of lisdexamfetamine are available?

Capsules: 10, 20, 30, 40, 50, 60, and 70 mg

How should I keep lisdexamfetamine stored?

Vyvanse should be stored at room temperature, 15 C to 30 C (59 F to 86 F), and protected from light.

Reference: FDA Prescribing Information

Quick GuideADHD Symptoms in Children

ADHD Symptoms in Children

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Reviewed on 9/12/2016
References
Reference: FDA Prescribing Information

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