What is Lincocin (lincomycin)?

Lincocin (lincomycin) is an injectable antibiotic effective against many types of bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Propionibacterium acnes, and others. Lincocin kills bacteria by interfering with the ability of bacteria to produce important proteins necessary for them to survive.

Common side effects of Lincocin include:

Serious side effects of Lincocin include:

Drug interactions of Lincocin include:

  • neuromuscular blocking medications such as Tracrium (atracurium),
  • Pavulon (pancuronium),
  • Zemuron (rocuronium),
  • Anectine (succinylcholine),
  • and vecuronium. 

There are no adequate studies done on Lincocin to determine safe and effective use in pregnant women. Lincocin may be excreted in small amounts in breast milk. To avoid the potential harm to nursing infants, a decision should be made whether to discontinue Lincocin or discontinue breastfeeding before using in nursing mothers.

What are the important side effects of Lincocin (lincomycin)?


Rare but sometimes fatal intestinal problems have occurred (pseudomembranous colitis) with use of lincomycin. Therefore, it should only be used to treat serious infections where less toxic antibiotics are not appropriate. It should not be used to treat nonbacterial infections such as upper respiratory infections.

Side effects of lincomycin are:

Like other antibiotics lincomycin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colon (pseudomembranous colitis).

Patients who develop signs of pseudomembranous colitis after treatment with lincomycin should contact their doctor or other health care professional immediately. Symptoms may include:

Lincocin (lincomycin) side effects list for healthcare professionals

The following adverse reactions have been reported with the use of lincomycin.

Gastrointestinal Disorders

Diarrhea, nausea, vomiting, glossitis, stomatitis, abdominal pain, abdominal discomfort, anal pruritus

Skin And Subcutaneous Tissue Disorders

Toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, dermatitis bullous, dermatitis exfoliative, erythema multiforme, rash, urticaria, pruritus

Infections And Infestations

Vaginal infection, pseudomembranous colitis, Clostridium difficile colitis

Blood And lymphatic System Disorders

Pancytopenia, agranulocytosis, aplastic anemia, leukopenia, neutropenia, thrombocytopenic purpura

Immune System

disorders Anaphylactic reaction, angioedema, serum sickness

Hepatobiliary Disorders

Jaundice, liver function test abnormal, transaminases increased

Renal And Urinary Disorders

Renal impairment, oliguria, proteinuria, azotemia

Cardiac Disorders

Cardio-respiratory arrest

Vascular Disorders

Hypotension, thrombophlebitis

Ear And Labyrinth Disorders

Vertigo, tinnitus

Neurologic Disorders

Headache, dizziness, somnolence

General Disorders And Administration Site Conditions

Injection site abscess sterile, injection site induration, injection site pain, injection site irritation

Event has been reported with intravenous injection.
Reported with intramuscular injection.

What drugs interact with Lincocin (lincomycin)?

Lincomycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used in caution in patients receiving such agents.

Treatment & Diagnosis

Medications & Supplements

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 3/16/2020
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