- Irritable Bowel Syndrome (IBS) Slideshow Pictures
- Digestive Disease Myths
- Irritable Bowel Syndrome (IBS) Quiz
- What is linaclotide (Linzess), and how does it work (mechanism of action)?
- What brand names are available for linaclotide (Linzess)?
- Is linaclotide (Linzess) available as a generic drug?
- Do I need a prescription for linaclotide (Linzess)?
- What are the side effects of linaclotide (Linzess)?
- What is the dosage for linaclotide (Linzess)?
- Which drugs or supplements interact with linaclotide (Linzess)?
- Is linaclotide (Linzess) safe to take if I'm pregnant or breastfeeding?
- What else should I know about linaclotide (Linzess)?
What is linaclotide (Linzess), and how does it work (mechanism of action)?
Linaclotide is an oral medication for the treatment of constipation. It is the first in a new class of drugs called guanylate cyclase-C agonists. It is used for relieving symptoms of irritable bowel syndrome (IBS) with constipation and for treating chronic constipation of unknown cause (idiopathic constipation). Linaclotide works locally in the intestine (it is not absorbed into the body) to increase bowel movements and reduce pain. Linaclotide's effects are due to an increase in the production of a chemical called cyclic guanosine monophosphate which increases fluid secretion into the intestine and reduces the sensitivity of pain-sensing nerves. The FDA approved linaclotide in August 2012.
What are the side effects of linaclotide (Linzess)?
The most common side effects of linaclotide are:
Linaclotide should be stopped if patients develop severe diarrhea. Other important side effects include:
Rarely, patients may experience passage of blood from the rectum.
What is the dosage for linaclotide (Linzess)?
The dose for treating IBS with constipation is 290 mcg once daily, and the dose for treating chronic idiopathic constipation is 145 mcg once daily. Linaclotide should be taken on an empty stomach at least 30 minutes before the first meal of the day.
Is linaclotide (Linzess) safe to take if I'm pregnant or breastfeeding?
Linaclotide has not been adequately evaluated in pregnant women.
It is not known whether linaclotide is excreted in human milk. It is unlikely that linaclotide is excreted in breast milk because it is poorly absorbed and therefore undetectable in blood at recommended doses.
What else should I know about linaclotide (Linzess)?
What preparations of linaclotide (Linzess) are available?
Capsules: 145 and 290 mcg
How should I keep linaclotide (Linzess) stored?
Linaclotide should be stored at room temperature, 15 C to 30 C (59 F to 86 F). It should be kept in the original container and protected from moisture. The dessicant (drying agent) should not be removed from the container.
Linaclotide (Linzess) is a guanylate cyclase-C agnoist drug prescribed for the relief of symptoms of irritable bowel syndrome with constipation and for the treatment of chronic constipation of unknown cause. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Constipation (Relief, Home Remedies, Treatment Medications)
Constipation is defined medically as fewer than three stools per week and severe constipation as less than one stool per week....
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms that include abdominal pain, bloating,...
IBS Triggers (Prevention)
Irritable bowel syndrome (IBS) is a functional disease that can affect the quality of those who suffer from this condition....
IBS-D (Irritable Bowel Syndrome with Diarrhea)
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include intestinal gas...
Treatment & Diagnosis
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.