lidocaine HCl injection

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is lidocaine-injection (local), and how does it work (mechanism of action)?

Lidocaine injection is a local anesthetic. This means that it reduces sensation or pain in the area of the body where it is injected and does not affect other areas. It is similar to bupivacaine (Marcaine), articaine (Zorcaine), and Mepivacaine (Carbocaine). These drugs reduce sensation or pain by blocking nerve impulses that send pain sensations to the brain. Lidocaine starts working within 90 seconds and the effects last about 20 minutes. The FDA approved lidocaine in November 1948.

What brand names are available for lidocaine-injection (local)?

Xylocaine, Xylocaine MPF

Is lidocaine-injection (local) available as a generic drug?


Do I need a prescription for lidocaine-injection (local)?


What are the side effects of lidocaine-injection (local)?

Common side effects of lidocaine are:

Other important side effects which may be serious include:

People allergic to anesthetics similar to lidocaine should not use lidocaine.

What is the dosage for lidocaine-injection (local)?

Dosing varies considerably depending on the use. Total recommended doses range from 20 mg to 300 mg.

Which drugs or supplements interact with lidocaine-injection (local)?

Administering lidocaine solutions containing epinephrine or norepinephrine (which are added to prolong the action of the lidocaine) to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe and prolonged high blood pressure. Such combinations should be avoided. A similar reaction may occur with drugs used to increase blood pressure (vasopressors).

Is lidocaine-injection (local) safe to take if I'm pregnant or breastfeeding?

Lidocaine has not been adequately studied in pregnant women. Studies in animals have not shown evidence of harm to the fetus.

It is not known whether lidocaine is excreted in breast milk.

What else should I know about lidocaine-injection (local)?

What preparations of lidocaine-injection (local) are available?

Injectable Solution: 0.5%, 1%, 1.5%, 2%, 4%, and 5%; 200, 400 and 800 mg/100 mL

How should I keep lidocaine-injection (local) stored?

All solutions should be stored at room temperature, 25 C (77 F) and protected from light.

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Lidocaine HCl injection (Xylocaine)is a medication used for local or regional anesthesia to perform certain surgeries and procedures. Side effects, drug interactions, and indication should be discussed with your doctor before having this medication administered.

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REFERENCE: FDA prescribing information.