- A Visual Guide to Heart Disease
- Medical Illustrations of the Heart Image Collection
- Take the Heart Disease Quiz!
- What is lidocaine injection?
- Is lidocaine injection available as a generic drug?
- Do I need a prescription for lidocaine injection?
- Why is lidocaine injection prescribed to patients?
- What are the side effects of lidocaine injection?
- What is the dosage for lidocaine injection?
- Which drugs or supplements interact with lidocaine injection?
- Is lidocaine injection safe to use during pregnancy or while breastfeeding?
- What else should I know about lidocaine injection?
What is lidocaine injection?
Lidocaine is an antiarrhythmic agent (affects heart rhythm) as well as a local anesthetic (amide type).
Quick GuideHeart Disease: Symptoms, Signs, and Causes
Why is lidocaine injection prescribed to patients?
Lidocaine is prescribed for local or regional anesthesia (loss of sensation) during surgical procedures as well as for control of ventricular arrhythmias associated with heart attack or cardiac surgery.
What are the side effects of lidocaine injection?
Side effects vary by dose and site of administration. The most common adverse reactions include:
Additional side effects include:
Rare, but serious side effects include:
What is the dosage for lidocaine injection?
The initial dose for anesthesia in adults depends on the procedure, necessary depth of anesthesia, blood flow to the region, desired duration of anesthesia, and condition of the patient. For anesthesia, the maximum dose is 4.5 mg/kg and should not exceed 300 mg per dose. For control of arrhythmias (abnormal heart rhythm), an initial intravenous or intraosseous (injected into bone) dose is 1 to 1.5 mg/kg. If providing dose by endotrachial tube the initial dose is 2 to 3.75 mg/kg. Lidocaine is rapidly metabolized. Any conditions that later liver functions may alter the half live of lidocaine.
Which drugs or supplements interact with lidocaine injection?
Dronedarone increases blood levels of lidocaine and its side effects by reducing its breakdown in the liver. Lidocaine increases the effect of bupivicaine liposomal because it increases the availability of bupivicaine. The two drugs should not be mixed. Carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol), phenobarbital, and rifampin may reduce blood levels of lidocaine by increasing its breakdown in the liver. Erythromycin, amprenavir (Agenerase), omeprazole (Prilosec), and ciprofloxacin (Cirpo, Cirpo XR, Proquin XR) may increase levels of lidocaine by reducing its breakdown in the liver.
Is lidocaine injection safe to use during pregnancy or while breastfeeding?
There are no adequate studies of use in pregnant women. Available evidence does not suggest harm to the fetus. Lidocaine crosses the placenta and does enter the fetal blood stream so close monitoring of the heart is recommended.
Lidocaine is excreted in breast milk so it should be used cautiously by nursing mothers. The amount absorbed by the infant is not expected to be significant.
What else should I know about lidocaine injection?
What preparations of lidocaine injection are available?
Injection Solution with or without preservatives: 0.4%, 0.5%, 0.8%, 1%, 1.5%, 2%, 4%, 5% in 2, 5, 10, 20, 30, 50, 250, 500 mL.
How should I keep lidocaine injection stored?
Lidocaine should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
How does lidocaine injection work?
Lidocaine is similar to bupivacaine and procaine. Lidocaine, like other local anesthetics causes a loss of sensation by reducing the flow of sodium in and out nerves to decrease the initiation and transfer of nerve signals. Compared to procaine, lidocaine has a more rapid onset, longer duration of action, and more potent activity. Lidocaine works as an antiarrhythmic by also decreasing conduction of electrical signals in damaged (ischemic) heart tissue.
When was lidocaine injection approved by the FDA?
Lidocaine was approved by the FDA in November 1948.
REFERENCE: FDA Prescribing Information.
Quick GuideHeart Disease: Symptoms, Signs, and Causes
lidocaine injection (Xylocaine) is a medication that is an antiarrhythmic agent and a local anesthetic used for local or regional anesthesia during surgical procedures of ventricular arrhythmias associated with heart attack or cardiac surgery. Side effects, dosage, storage, drug interactions, and pregnancy safety information should be reviewed prior to administering this medication.
Related Disease Conditions
An abscessed tooth is an infection within a tooth that has spread to the root. Symptoms of an abscessed tooth may include pain,...
An arrhythmia is an abnormal heart rhythm. With an arrhythmia, the heartbeats may be irregular or too slow (bradycardia), to...
The shoulder is the most often dislocated joint in the body due to its mobility. Dislocation occurs when the head of the humerus...
A toothache is a pain on or around a tooth. It may be caused by a variety of things from a cavity, abscess, or even sinusitis....
Heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack...
Abnormal Heart Rhythms (Heart Rhythm Disorders)
Heart rhythm disorders vary from minor palpitations, premature atrial contractions (PACs), premature ventricular contractions...
Piriformis syndrome may develop if the piriformis muscle spasms and compresses the sciatic nerve. This causes buttock pain that...
Heart Attacks in Women
Heart disease, particularly coronary artery disease is the leading cause of heart attacks. Women are more likely to die from a...
Learn more about cavities including symptoms, treatment, and prevention. See how tooth decay, plaque, and bacteria contribute to...
Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Daily Health News
Healthy Heart Resources
Subscribe to MedicineNet's Heart Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top lidocaine-injection Related ArticlesComplete List
Abscessed Tooth GuideAn abscessed tooth is an infection within a tooth that has spread to the root. Symptoms of an abscessed tooth may include pain, swelling, tenderness, redness, and the presence of a pus-filled lesion on the gum. A dental professional diagnoses an abscessed tooth and dental X-rays may be required. An abscessed tooth is treated with a root canal.
Arrhythmia (Irregular Heartbeat)An arrhythmia is an abnormal heart rhythm. With an arrhythmia, the heartbeats may be irregular or too slow (bradycardia), to rapid (tachycardia), or too early. When a single heartbeat occurs earlier than normal, it is called a prmature contraction.
CavitiesLearn more about cavities including symptoms, treatment, and prevention. See how tooth decay, plaque, and bacteria contribute to the creation of cavities and how regular brushing and flossing can help prevent dental caries.
Dislocated ShoulderThe shoulder is the most often dislocated joint in the body due to its mobility. Dislocation occurs when the head of the humerus is dislocated from its socket. Symptoms and signs of a shoulder dislocation include nausea and vomiting, lightheadedness, weakness, and sweating. There are various methods of reducing a dislocation and returning the humeral head to its normal place. The method for reduction of a shoulder dislocation depends upon the type of dislocation, the patient, the situation, and the clinician's experience. Intravenous narcotics and muscle relaxants are often administered to relax the muscles and relieve pain.
Epidural Steroid InjectionAn epidural steroid injection is a common procedure to treat spinal nerve irritation that causes chronic low back pain and/or leg pain (radicular pain). Disc herniation is also treated with epidural steroid injections. Epidural injections are also used to treat nerve compression in the neck (cervical radiculopathy).The procedure is quick and simple.
Heart AttackHeart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack can cause chest pain, heart failure, and electrical instability of the heart.
Heart Attack in WomenHeart disease, particularly coronary artery disease is the leading cause of heart attacks. Women are more likely to die from a heart attack than men. High cholesterol, high blood pressure, obesity, and high triglycerides are contributors to heart disease. Some of the common symptoms of a heart attack in women include chest pain, shortness of breath, nausea, feeling faint or woozy, and more. Heart disease can be prevented by lifestyle changes and controlling high blood pressure, cholesterol, weight, and diseases such as diabetes.
Heart Attack TreatmentA heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to prevent or stop this damage to the heart muscle. Heart attack treatments included medications, procedures, and surgeries to protect the heart muscle against injury.
Heart Rhythm DisordersHeart rhythm disorders vary from minor palpitations, premature atrial contractions (PACs), premature ventricular contractions (PVCs), sinus tachycardia, and sinus brachycardia, to abnormal heart rhythms such as tachycardia, ventricular fibrillation, ventricular flutter, atrial fibrillation, atrial flutter, paroxysmal supraventricular tachycardia (PSVT), Wolf-Parkinson-White syndrome, brachycardia, or heart blocks. Treatment is dependent upon the type of heart rhythm disorder.
Piriformis SyndromePiriformis syndrome may develop if the piriformis muscle spasms and compresses the sciatic nerve. This causes buttock pain that radiates down the back of the leg along the sciatic nerve. Symptoms include numbness, a pins and needles tingling sensation, and low back pain. Treatment of piriformis syndrome depends upon the syndrome's phase:
- recovery, or
Root CanalA root canal is a dental procedure that's used to save an infected tooth. Treatment involves removing the tooth's nerve and pulp and then cleaning and sealing the tooth. Symptoms and signs that indicate a root canal is needed include toothache, discoloration, swelling, tenderness, prolonged sensitivity to hot or cold, and a persistent pimple on the gums. Typically, a root canal is no more painful than having a filling placed.
Surgery QuestionsSurgery is the branch of medicine that employs operations in the treatment of disease or injury. Prior to surgery you might consider asking your surgeon questions about the operation (procedure).
Toothache OverviewA toothache is a pain on or around a tooth. It may be caused by a variety of things from a cavity, abscess, or even sinusitis. Toothache symptoms include pain, headache, ear ache, bad taste in the mouth, and gum swelling. Dental X-rays and other tests performed by a dentist are used to diagnose the cause of a toothache. Tootache treatment depends on the underlying cause. Taking proper care of the teeth and gums can help prevent toothache.