What is Latisse (bimatoprost)?
Latisse (bimatoprost) is a synthetic prostaglandin analog that resembles and mimics the effects of natural chemicals (prostaglandins) produced by the body, and is used for reducing intraocular pressure (IOP) and increasing the growth of eyelashes. The exact mechanism of action is unknown.
Latisse may reduce IOP by increasing the outflow of aqueous humor from the eye of individuals with narrow angle glaucoma. Excessive aqueous humor may cause optic nerve damage and visual loss. Latisse may increase eyelash growth by increasing the duration of the growing phase of the eyelash.
Common side effects of Latisse include:
- itching of the eyes,
- growth of eyelashes,
- eye irritation,
- dry eyes,
- eye redness,
- eyelash darkening and reversible darkening of skin around the eyes,
- permanent brown pigmentation in the colored part of the eye, and
- hair growth in other areas of the body that it comes in contact with.
Serious side effects of Latisse include severe burning or itching of your eyes.
Drug interactions of Latisse include prostaglandin-like drugs used for treating elevated IOP when Latisse is used for eyelash growth. Latisse should be administered at least five minutes before or after other eye medications.
Latisse contains benzalkonium chloride, which may be absorbed by soft contact lenses. Contact lenses should be removed prior to application of Latisse, and may be reinserted 15 minutes following administration.
What are the important side effects of Latisse (bimatoprost)?
Common side effects include:
- Itching of the eyes
- Growth of eyelashes
- Eye irritation
- Dry eyes
- Eye redness
- Eye lash darkening and reversible darkening of skin around the eyes
Bimatoprost may also cause permanent brown pigmentation in the colored part of the eye and hair growth in other areas of the body that it comes in contact with.
Latisse (bimatoprost) side effects list for healthcare professionals
The following adverse reactions are described elsewhere in the labeling:
- Effects on Intraocular Pressure
- Iris Pigmentation
- Lid Pigmentation
- Hair Growth Outside the Treatment Area
- Intraocular Inflammation
- Macular Edema
Clinical Trial Experience
The following information is based on clinical trial results from a multicenter, double-masked, randomized, vehicle-controlled, parallel study including 278 adult patients for four months of treatment.
The most frequently reported adverse reactions were:
- eye pruritus,
- conjunctival hyperemia,
- skin hyperpigmentation,
- ocular irritation,
- dry eye symptoms, and
- periorbital erythema.
These reactions occurred in less than 4% of patients. Additional adverse reactions seen in clinical trials experience include foreign body sensation, hair growth abnormal, and iris hyperpigmentation.
Additional adverse reactions reported with bimatoprost ophthalmic solution (Umigan) for the reduction of intraocular pressure include:
- ocular dryness,
- visual disturbance,
- ocular burning,
- eye pain,
- superficial punctate keratitis,
- eye discharge,
- allergic conjunctivitis,
- conjunctival edema,
- infections (primarily colds and upper respiratory tract infections),
- headaches, and
The following adverse reactions have been identified during postapproval use of Latisse. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
The reactions include:
- dry skin of the eyelid and/or periocular area,
- eye swelling,
- eyelid edema,
- hypersensitivity (local allergic reactions),
- lacrimation increased,
- madarosis and trichorrhexis (temporary loss of a few lashes to loss of sections of eyelashes, and temporary eyelash breakage, respectively),
- periorbital and lid changes associated with a deepening of the eyelid sulcus,
- rash (including macular and erythematous),
- skin discoloration (periorbital), and
- vision blurred.
Latisse (bimatoprost) is a synthetic prostaglandin analog that resembles and mimics the effects of natural chemicals (prostaglandins) produced by the body, and is used for reducing intraocular pressure (IOP) and increasing the growth of eyelashes. The exact mechanism of action is unknown. Common side effects of Latisse include itching of the eyes, growth of eyelashes, eye irritation, dry eyes, eye redness, eyelash darkening and reversible darkening of skin around the eyes, permanent brown pigmentation in the colored part of the eye, and hair growth in other areas of the body that it comes in contact with. Serious side effects of Latisse include severe burning or itching of your eyes. Use of Latisse in pregnancy has not been adequately evaluated. It is unknown if Latisse is excreted in human breast milk.
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Related Disease Conditions
Eye allergy (or allergic eye disease) are typically associated with hay fever and atopic dermatitis. Medications and cosmetics may cause eye allergies. Allergic eye conditions include allergic conjunctivitis, conjunctivitis with atopic dermatitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis. Dry eye, tear-duct obstruction, and conjunctivitis due to infection are frequently confused with eye allergies. Eye allergies may be treated with topical antihistamines, decongestants, topical mast-cell stabilizers, topical anti-inflammatory drugs, systemic medications, and allergy shots.
Glaucoma is a common eye condition in which the fluid pressure inside the eye rises because of slowed fluid drainage from the eye. If untreated, glaucoma may damage the optic nerve and other parts of the eye, causing the loss of vision or even blindness.
Eye Problems and Diabetes
Diabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
Dry eyes are caused by an imbalance in the tear-flow system of the eye, but also can be caused by the drying out of the tear film. This can be due to dry air created by air conditioning, heat, or other environmental conditions. Treatment may involve self-care measures, medications, or rarely, surgery.
Eye Care and Eye Disorder
Many common eye disorders resolve without treatment and some may be managed with over-the-counter (OTC) products. It's important to visit a physician or ophthalmologist is the problem involves the eyeball itself or the condition hasn't improved after 72 hours of use of an eye-care OTC product.
Eyeglasses, Sunglasses, and Magnifying Glasses
Nonprescription eyeglasses are available over the counter (OTC) and are typically used by people who can no longer read fine print. OTC trifocals are helpful for those who require multiple distances or focal lengths for near and intermediate tasks. OTC sunglasses should offer 100% protection from the sun's UVA and UVB rays. OTC magnifying glasses are useful for viewing tiny objects or fine print.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.