- Heart Disease (Coronary Artery Disease) Slideshow Pictures
- Atrial Fibrillation Slideshow: Causes, Tests and Treatment
- Take the Heart Disease Quiz!
- Lasix (furosemide) vs. bumetanide: What's the difference?
- What are Lasix and bumetanide?
- What are the side effects of Lasix and bumetanide?
- What is the dosage of Lasix vs. bumetanide?
- What drugs interact with Lasix and bumetanide?
- Are Lasix and bumetanide safe to use while pregnant or breastfeeding?
Lasix (furosemide) vs. bumetanide: What's the difference?
- Lasix (furosemide) and bumetanide are potent diuretics (water pills) used treat excess accumulation of fluid or swelling of the body (edema) caused by heart failure, kidney disease, chronic kidney failure, or liver disease.
- Lasix is also used with other high blood pressure medications to treat high blood pressure (hypertension), and bumetanide is used off-label to treat hypertension.
- Lasix is a brand name for furosemide.
- Side effects of Lasix and bumetanide that are similar include dehydration, nausea, and ringing in the ears.
- Side effects of Lasix that are different from bumetanide include low blood pressure, electrolyte depletion, yellowing skin and eyes (jaundice), sensitivity to light, rash, pancreatitis, diarrhea, abdominal pain, dizziness, increased blood sugar, and increased uric acid levels.
- Side effects of bumetanide that are different from Lasix include dry mouth, thirst, weakness, drowsiness, reduced kidney function, heart arrhythmias, muscle aches and pains, and vomiting.
What are Lasix and bumetanide?
Lasix is a “loop” diuretic (water pill) that is used to eliminate water and salt (composed of sodium and chloride) from the body. In the kidneys, salt, water, and other small molecules are filtered out of the blood and into the kidney tubules. This filtered fluid ultimately becomes urine. Most of the sodium, chloride, and water filtered out of the blood are reabsorbed back into the blood before the fluid becomes urine. Lasix works by blocking the absorption of salt and water from the filtered fluid in the kidney tubules, causing an increase in the output of urine (diuresis).
Bumetanide is a potent diuretic (water pill) that causes a profound increase in urine output (diuresis) by preventing the kidney from retaining fluid prescribed for the management of edema associated with congestive heart failure, liver and kidney disease, and off-label treatment for high blood pressure. Specifically, it blocks the reabsorption of sodium and fluid from the kidney's tubules. It is in a class of diuretics called "loop" diuretics, which also includes Lasix (furosemide) and torsemide (Demadex).
What are the side effects of Lasix and bumetanide?
Common side effects of furosemide are:
Other important side effects include:
- Ringing in the ears (tinnitus)
- Sensitivity to light (photophobia)
- Abdominal pain
Increased blood sugar and uric acid levels also may occur.
Potent diuretics like bumetanide can cause low blood levels of potassium, magnesium, sodium, and calcium. Additionally, fluid losses can occur leading to dehydration.
The symptoms of dehydration may include:
- Dry mouth
- Reduced kidney function
- Heart arrhythmias
- Muscle aches and pains
Toxicity to the inner ear in the form of tinnitus (ringing in the ear) and hearing loss have been associated with loop diuretics. High plasma levels of bumetanide are toxic to the inner ear of animals. These effects on the inner ear are far more common with intravenous use of the drugs. High uric acid concentrations in the blood leading to attacks of gouty arthritis may occur during diuretic therapy.
Latest Heart News
Daily Health News
What is the dosage of Lasix vs. bumetanide?
The usual starting oral dose for treatment of edema in adults is 20-80 mg as a single dose. The same dose or an increased dose may be administered 6-8 hours later. Doses may be increased 20-40 mg every 6-8 hours until the desired effect occurs. The effective dose may be administered once or twice daily. Some patients may require 600 mg daily.
The starting oral dose for children is 2 mg/kg. The starting dose may be increased by 1-2 mg/kg every 6 hours until the desired effect is achieved. Doses greater than 6 mg/kg are not recommended.
The dose for most patients is 0.5 to 2 mg daily by mouth. Doses may be increased every 4 to 5 hours to a maximum dose of 10 mg daily. Intravenous (IV) or intramuscular (IM) injections may be used in place of tablets when oral administration is not possible. The IV dose is 1 mg initially followed by 0.5 to 2 mg/hour, and the IM dose is 0.5 to 10 mg daily. Dosing of bumetanide and other loop diuretics varies greatly among patients, and doses are carefully adjusted by physicians. Bumetanide may be taken with or without food.
What drugs interact with Lasix and bumetanide?
- Administration of Lasix with aminoglycoside antibiotics (for example, gentamicin) or ethacrynic acid (Edecrin, another diuretic) may cause hearing damage.
- Lasix competes with aspirin for elimination in the urine by the kidneys. Concomitant use of Lasix and aspirin may, therefore, lead to high blood levels of aspirin and aspirin toxicity.
- Lasix also may reduce excretion of lithium (Eskalith, Lithobid) by the kidneys, causing increased blood levels of lithium and possible side effects from lithium.
- Sucralfate (Carafate) reduces the action of Lasix by binding Lasix in the intestine and preventing its absorption into the body. Ingestion of Lasix and sucralfate should be separated by two hours.
- When combined with other antihypertensive drugs there is an increased risk of low blood pressure or reduced kidney function.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) -- for example, ibuprofen, indomethacin (Indocin, Indocin-SR) -- may interfere with the blood pressure-reducing effect of Lasix.
- Bumetanide can cause low blood potassium, calcium, and magnesium levels. These changes can increase the risk of toxicity from digoxin (Lanoxin).
- Combining bumetanide with other diuretics such as metolazone (Zaroxolyn), hydrochlorothiazide, or chlorthalidone (Hygroton) can exaggerate the losses of potassium and magnesium.
- The body's ability to eliminate lithium (Lithobid, Eskalith) may decrease in patients receiving bumetanide. Therefore, careful monitoring of lithium levels in blood is recommended when bumetanide and lithium are taken together in order to prevent increases in lithium levels and lithium toxicity.
- Indomethacin (Indocin) can reduce the diuretic and blood pressure-lowering effects of other loop diuretics (for example Lasix) and it probably can do the same with bumetanide. Other nonsteroidal anti-inflammatory drugs (NSAIDs) -- for example, ibuprofen (Motrin), naproxen (Naprosyn) -- may interact similarly.
- Concomitant use of bumetanide and aminoglycosides may increase the risk of hearing impairment since both agents can affect hearing.
Are Lasix and bumetanide safe to use while pregnant or breastfeeding?
There have been no adequate studies on the effects of bumetanide on the fetus. Thus, the doctor must carefully weigh the potential but unknown risks and benefits of bumetanide before prescribing it for pregnant women.
It is not known if bumetanide is excreted into breast milk. Thus, the doctor must carefully weigh its potential benefits against the unknown risks before prescribing it to women who are breastfeeding.
Lasix (furosemide) and bumetanide are potent diuretics (water pills) used to treat excess accumulation of fluid or swelling of the body (edema) caused by heart failure, kidney disease, chronic kidney failure, or liver disease. Lasix is also used with other high blood pressure medications to treat high blood pressure (hypertension), and bumetanide is used off-label to treat hypertension.
Multimedia: Slideshows, Images & Quizzes
Heart Disease: Causes of a Heart Attack
Heart disease prevention includes controlling risk factors like diet, exercise, and stress. Heart disease symptoms in women may...
High Blood Pressure (Hypertension): Symptoms, Causes, Treatments
What causes high blood pressure (hypertension)? Know the warning signs and symptoms of high blood pressure. Read about high blood...
Hypertension: What High Blood Pressure Can Do to Your Body
High blood pressure puts you at risk for a number of other conditions. Here's what to look out for.
Heart Disease: Symptoms, Signs, and Causes
What is heart disease (coronary artery disease)? Learn about the causes of heart disease. Symptoms of heart disease include chest...
High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes
Take this quiz and test your IQ of high blood pressure (hypertension), the cardiovascular disease that causes most strokes and...
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Kidney Disease Quiz: Test Your Medical IQ
Kidney disease is common. Take this kidney disease quiz to test your knowledge and learn the symptoms, causes and types of kidney...
Liver Disease Quiz: Fatty Liver Disease, Cirrhosis & Symptoms
What is liver disease? Take the Liver Disease Quiz and test your knowledge about this organ and its function.
Heart Failure Quiz
What is heart failure? Learn about this dangerous condition, as well as who is at risk, and what to do about it.
Picture of Hypertension
High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140...
Related Disease Conditions
Congestive Heart Failure (CHF) Symptoms, Treatment, and Life Expectancy
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Liver disease can be cause by a variety of things including infection (hepatitis), diseases, for example, gallstones, high cholesterol or triglycerides, blood flow obstruction to the liver, and toxins (medications and chemicals). Symptoms of liver disease depends upon the cause and may include nausea, vomiting, upper right abdominal pain, and jaundice. Treatment depends upon the cause of the liver disease.
High Blood Pressure (Hypertension) Signs, Causes, Diet, and Treatment
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to the heart. Heart disease can lead to heart attack. Risk factors for heart disease include: Smoking High blood pressure High cholesterol Diabetes Family history Obesity Angina, shortness of breath, and sweating are just a few symptoms that may indicate a heart attack. Treatment of heart disease involves control of heart disease risk factors through lifestyle changes, medications, and/or stenting or bypass surgery. Heart disease can be prevented by controlling heart disease risk factors.
Second Source article from Government
Hypertension-Related Kidney Disease
Second Source WebMD Medical Reference
Diabetes and Kidney Disease
In the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. albumin and eGFR are two key markers for kidney disease in people with diabetes. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease. For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
Treatment & Diagnosis
Medications & Supplements
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.