Larch Arabinogalactan

Reviewed on 9/17/2019

What other names is Larch Arabinogalactan known by?

Abies gmelinii, AG, Ara-6, Arabinogalactan de Alerce, Arabinogalactan, Arabinogalactane, Arabinogalactane de Meleze, Arabinogalactane de Mélèze, Arabinogalactin, Arabinogalactine, Dietary Fiber, Fibre Alimentaire, Fibre Soluble, Gmelinii, Gomme de Mélèze, Larch, Larch Gum, Larch Tree, Larix, Larix dahurica, Larix decidua, Larix europaea, Larix gmelinii, Larix occidentalis, Lch, Mélèze, Mélèze d'Europe, Mongolian Larch, Mongolian Larchwood, Pinus Larix, Soluble Fiber, Stractan, Western Larch, Western Larch Arabinogalactan, Wood Gum, Wood Sugar.

What is Larch Arabinogalactan?

Arabinogalactan is a starch-like chemical that is found in many plants, but it is found in highest concentrations in Larch trees. Larch arabinogalactan is used for medicine. Most of the larch arabinogalactan you will find in stores is produced from Western Larch (Larch occidentalis). However, larch arabinogalactan can also be produced by other larch tree species.

Larch arabinogalactan is used for infections, including the common cold, flu, H1N1 (swine) flu, ear infections in children, and HIV/AIDS. It is also used to treat liver cancer, as well as a brain condition caused by liver damage (hepatic encephalopathy). Some people use it to provide dietary fiber, lower cholesterol, and to boost the immune system.

In foods, larch arabinogalactan is used as a stabilizer, binder, and sweetener.


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Insufficient Evidence to Rate Effectiveness for...

  • High cholesterol. Early research shows that taking larch arabinogalactan does not lower total cholesterol, low-density lipoprotein (LDL or “bad”) cholesterol, other blood fats called triglycerides, body weight, blood pressure, or sugar levels in healthy people. It is not yet known whether larch arabinogalactan improves these outcomes in people with high cholesterol.
  • Pneumonia. Early research shows that taking a specific larch arabinogalactan product (ResistAid) increases the immune system response to shots (vaccines) used to prevent pneumonia in healthy adults.
  • Common cold.
  • Flu.
  • H1N1 (swine) flu.
  • Liver disease.
  • Liver cancer.
  • Earache (otitis media).
  • Dietary fiber supplementation.
  • Boosting the immune system.
  • Inflammation.
  • Other conditions.
More evidence is needed to rate the effectiveness of larch arabinogalactan for these uses.

How does Larch Arabinogalactan work?

Larch arabinogalactan is a fiber that ferments in the intestine. It might increase intestinal bacteria, such as Lactobacillus, and have other effects that could be beneficial to digestive tract health. There is also information that suggests larch arabinogalactan might boost the immune system and help prevent cancer cells in the liver from growing.

Are there safety concerns?

Larch arabinogalactan is LIKELY SAFE when eaten in food amounts. It's POSSIBLY SAFE when taken by mouth in appropriate amounts for less than 6 months. It can cause side effects such as bloating and intestinal gas (flatulence). Not enough is known about the safety of long-term use of larch arabinogalactan.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking larch arabinogalactan if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

“Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Larch arabinogalactan might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using larch arabinogalactan.

Organ transplant recipients: Larch arabinogalactan might increase the risk of organ transplant rejection. If you have received an organ transplant, don't use larch arabinogalactan until more is known.


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Are there any interactions with medications?

Medications that decrease the immune system (Immunosuppressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Larch arabinogalactan seems to increase the immune system. By increasing the Larch arabinogalactan seems to increase activity of the immune system. By increasing the immune system, larch arabinogalactan might decrease the effectiveness of medications that decrease the immune system.

Some medications that decrease immune system activity include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing considerations for Larch Arabinogalactan.

The appropriate dose of larch arabinogalactan depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for larch arabinogalactan. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.


Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

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Reviewed on 9/17/2019

Ambrus, J. L., Ambrus, C. M., Shields, R., Mink, I. B., and Cleveland, C. Effect of galactose and sugar substitutes on blood insulin levels in normal and obese individuals. J.Med. 1976;7(6):429-438. View abstract.

Bayliss, C. E. and Houston, A. P. Characterization of plant polysaccharide- and mucin-fermenting anaerobic bacteria from human feces. Appl.Environ.Microbiol. 1984;48(3):626-632. View abstract.

Beuth, J., Ko, H. L., Oette, K., Pulverer, G., Roszkowski, K., and Uhlenbruck, G. Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and D-galactose. J.Cancer Res.Clin.Oncol. 1987;113(1):51-55. View abstract.

Beuth, J., Ko, H. L., Schirrmacher, V., Uhlenbruck, G., and Pulverer, G. Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan. Clin.Exp.Metastasis 1988;6(2):115-120. View abstract.

Classen, B., Mau, S. L., and Bacic, A. The arabinogalactan-proteins from pressed juice of Echinacea purpurea belong to the hybrid class of hydroxyproline-rich glycoproteins. Planta Med. 2005;71(1):59-66. View abstract.

Draper, P., Khoo, K. H., Chatterjee, D., Dell, A., and Morris, H. R. Galactosamine in walls of slow-growing mycobacteria. Biochem.J. 10-15-1997;327 ( Pt 2):519-525. View abstract.

Egert, D. and Beuscher, N. Studies on antigen specifity of immunoreactive arabinogalactan proteins extracted from Baptisia tinctoria and Echinacea purpurea. Planta Med. 1992;58(2):163-165. View abstract.

Glatman-Freedman, A., Martin, J. M., Riska, P. F., Bloom, B. R., and Casadevall, A. Monoclonal antibodies to surface antigens of Mycobacterium tuberculosis and their use in a modified enzyme-linked immunosorbent spot assay for detection of mycobacteria. J.Clin.Microbiol. 1996;34(11):2795-2802. View abstract.

Gonda, R., Tomoda, M., Ohara, N., and Takada, K. Arabinogalactan core structure and immunological activities of ukonan C, an acidic polysaccharide from the rhizome of Curcuma longa. Biol.Pharm.Bull. 1993;16(3):235-238. View abstract.

Groman, E. V. and Gou, D. Development of an immunoassay for larch arabinogalactan and its use in the detection of larch arabinogalactan in rat blood. Carbohydr.Res. 6-11-1997;301(1-2):69-76. View abstract.

Guther, M. L., Travassos, L. R., and Schenkman, S. Identification of C3 acceptors responsible for complement activation in Crithidia fasciculata. J.Protozool. 1988;35(4):475-480. View abstract.

Hagmar, B., Ryd, W., and Skomedal, H. Arabinogalactan blockade of experimental metastases to liver by murine hepatoma. Invasion Metastasis 1991;11(6):348-355. View abstract.

Hauer, J. and Anderer, F. A. Mechanism of stimulation of human natural killer cytotoxicity by arabinogalactan from Larix occidentalis. Cancer Immunol.Immunother. 1993;36(4):237-244. View abstract.

Janczura, E., Abou-Zeid, C., Gailly, C., and Cocito, C. Chemical identification of some cell-wall components of microorganisms isolated from human leprosy lesions. Zentralbl.Bakteriol.Mikrobiol.Hyg.[A] 1981;251(1):114-125. View abstract.

Kiyohara, H., Cyong, J. C., and Yamada, H. Relationship between structure and activity of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa. Carbohydr.Res. 10-31-1989;193:193-200. View abstract.

Kleinhenz, M. E., Ellner, J. J., Spagnuolo, P. J., and Daniel, T. M. Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan. Monocyte dependence and indomethacin reversibility. J.Clin.Invest 1981;68(1):153-162. View abstract.

Kremer, L. S. and Besra, G. S. Current status and future development of antitubercular chemotherapy. Expert.Opin.Investig.Drugs 2002;11(8):1033-1049. View abstract.

Kremer, L., Guerardel, Y., Gurcha, S. S., Locht, C., and Besra, G. S. Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile. Microbiology 2002;148(Pt 10):3145-3154. View abstract.

Kundu, M., Basu, J., and Chakrabarti, P. Purification and characterization of an extracellular lectin from Mycobacterium smegmatis. FEBS Lett. 10-9-1989;256(1-2):207-210. View abstract.

Lagrange, P. H. [New information on the structure of mycobacteria]. Rev.Pneumol.Clin. 1994;50(5):199-206. View abstract.

Larch arabinogalactan. Altern.Med.Rev. 2000;5(5):463-466. View abstract.

Macfarlane, S., McBain, A. J., and Macfarlane, G. T. Consequences of biofilm and sessile growth in the large intestine. Adv.Dent.Res. 1997;11(1):59-68. View abstract.

Maciejewska, A., Wojtczak, J., Bielichowska-Cybula, G., Domanska, A., Dutkiewicz, J., and Molocznik, A. [Biological effect of wood dust]. Med.Pr 1993;44(3):277-288. View abstract.

Melancon-Kaplan, J., Hunter, S. W., McNeil, M., Stewart, C., Modlin, R. L., Rea, T. H., Convit, J., Salgame, P., Mehra, V., Bloom, B. R., and . Immunological significance of Mycobacterium leprae cell walls. Proc.Natl.Acad.Sci.U.S.A 1988;85(6):1917-1921. View abstract.

Moreno, C., Mehlert, A., and Lamb, J. The inhibitory effects of mycobacterial lipoarabinomannan and polysaccharides upon polyclonal and monoclonal human T cell proliferation. Clin.Exp.Immunol. 1988;74(2):206-210. View abstract.

Morris, S. L. Antigens of the Mycobacterium avium, Mycobacterium intracellulare complex. Eur.J.Epidemiol. 1991;7(4):328-338. View abstract.

Muchmore, A. V., Decker, J. M., and Blaese, R. M. Spontaneous cytotoxicity by human peripheral blood monocytes: inhibition by monosaccharides and oligosaccharides. Immunobiology 1981;158(3):191-206. View abstract.

Nergard, C. S., Diallo, D., Michaelsen, T. E., Malterud, K. E., Kiyohara, H., Matsumoto, T., Yamada, H., and Paulsen, B. S. Isolation, partial characterisation and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. J.Ethnopharmacol. 2004;91(1):141-152. View abstract.

Nergard, C. S., Matsumoto, T., Inngjerdingen, M., Inngjerdingen, K., Hokputsa, S., Harding, S. E., Michaelsen, T. E., Diallo, D., Kiyohara, H., Paulsen, B. S., and Yamada, H. Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Carbohydr.Res. 1-17-2005;340(1):115-130. View abstract.

Odonmazig, P., Ebringerova, A., Machova, E., and Alfoldi, J. Structural and molecular properties of the arabinogalactan isolated from Mongolian larchwood (Larix dahurica L.). Carbohydr.Res. 1-15-1994;252:317-324. View abstract.

Owen, P. L. and Johns, T. Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout. J.Ethnopharmacol. 1999;64(2):149-160. View abstract.

Popov, S. V., Popova, G. Y., Ovodova, R. G., Bushneva, O. A., and Ovodov, Y. S. Effects of polysaccharides from Silene vulgaris on phagocytes. Int.J.Immunopharmacol. 1999;21(9):617-624. View abstract.

Prescott, J. H., Enriquez, P., Jung, C., Menz, E., and Groman, E. V. Larch arabinogalactan for hepatic drug delivery: isolation and characterization of a 9 kDa arabinogalactan fragment. Carbohydr.Res. 11-30-1995;278(1):113-128. View abstract.

Rampton, D. S., Cohen, S. L., Crammond, V. D., Gibbons, J., Lilburn, M. F., Rabet, J. Y., Vince, A. J., Wager, J. D., and Wrong, O. M. Treatment of chronic renal failure with dietary fiber. Clin.Nephrol. 1984;21(3):159-163. View abstract.

Roy, A., Agarwal, A., and Ralhan, R. Anti-arabinogalactan IgM/IgG ratio: a screening index for leprosy patients. Indian J.Lepr. 1990;62(4):435-442. View abstract.

Rumyantseva, N. I. Arabinogalactan proteins: involvement in plant growth and morphogenesis. Biochemistry (Mosc.) 2005;70(10):1073-1085. View abstract.

Salyers, A. A., Arthur, R., and Kuritza, A. Digestion of larch arabinogalactan by a strain of human colonic Bacteroides growing in continuous culture. J.Agric.Food Chem. 1981;29(3):475-480. View abstract.

Salyers, A. A., Vercellotti, J. R., West, S. E., and Wilkins, T. D. Fermentation of mucin and plant polysaccharides by strains of Bacteroides from the human colon. Appl.Environ.Microbiol. 1977;33(2):319-322. View abstract.

Schepetkin, I. A., Faulkner, C. L., Nelson-Overton, L. K., Wiley, J. A., and Quinn, M. T. Macrophage immunomodulatory activity of polysaccharides isolated from Juniperus scopolorum. Int.Immunopharmacol. 2005;5(13-14):1783-1799. View abstract.

Sensi, P. Approaches to the development of new antituberculosis drugs. Rev.Infect.Dis. 1989;11 Suppl 2:S467-S470. View abstract.

Shanmugam, M., Mody, K. H., and Siddhanta, A. K. Blood anticoagulant sulphated polysaccharides of the marine green algae Codium dwarkense (Boergs.) and C. tomentosum (Huds.) Stackh. Indian J.Exp.Biol. 2001;39(4):365-370. View abstract.

Singha, P. K., Roy, S., and Dey, S. Antimicrobial activity of Andrographis paniculata. Fitoterapia 2003;74(7-8):692-694. View abstract.

Takayama, K., Wang, C., and Besra, G. S. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin.Microbiol.Rev. 2005;18(1):81-101. View abstract.

Thude, S., Classen, B., Blaschek, W., Barz, D., and Thude, H. Binding studies of an arabinogalactan-protein from Echinacea purpurea to leucocytes. Phytomedicine. 2006;13(6):425-427. View abstract.

Tsuji, S., Matsumoto, M., Takeuchi, O., Akira, S., Azuma, I., Hayashi, A., Toyoshima, K., and Seya, T. Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of toll-like receptors. Infect.Immun. 2000;68(12):6883-6890. View abstract.

Uhlenbruck, G., Beuth, J., Oette, K., Roszkowski, W., Ko, H. L., and Pulverer, G. Prevention of experimental liver metastases by arabinogalactan. Naturwissenschaften 1986;73(10):626-627. View abstract.

Vince, A. J., McNeil, N. I., Wager, J. D., and Wrong, O. M. The effect of lactulose, pectin, arabinogalactan and cellulose on the production of organic acids and metabolism of ammonia by intestinal bacteria in a faecal incubation system. Br.J.Nutr. 1990;63(1):17-26. View abstract.

Wack, M., Classen, B., and Blaschek, W. An acidic arabinogalactan-protein from the roots of Baptisia tinctoria. Planta Med. 2005;71(9):814-818. View abstract.

Wopfner, N., Gadermaier, G., Egger, M., Asero, R., Ebner, C., Jahn-Schmid, B., and Ferreira, F. The spectrum of allergens in ragweed and mugwort pollen. Int.Arch.Allergy Immunol. 2005;138(4):337-346. View abstract.

Yamada, H., Kiyohara, H., Cyong, J. C., and Otsuka, Y. Structural characterisation of an anti-complementary arabinogalactan from the roots of Angelica acutiloba Kitagawa. Carbohydr.Res. 2-1-1987;159(2):275-291. View abstract.

Yamamoto, S., Sakai, I., and Iseki, S. Purification, composition and immunochemical properties of arabinogalactan-protein H active glycopeptides from Euonymus sieboldiana seeds. Immunol.Commun. 1981;10(3):215-236. View abstract.

Anon. Best herb for fighting off colds. Bottom Line 1999;20:1.

D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.

Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103. View abstract.

Kim LS, Waters RF, Burkholder PM. Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial. Altern Med Rev 2002;7:138-49. View abstract.

Kind LS, Macedo-Sobrinho B, Ako D. Enhanced vascular permeability induced in mice by larch arabinogalactan. Immunology 1970;19:799-807. View abstract.

Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9. View abstract.

Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. View abstract.

Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. View abstract.