- Related Diseases
- Images & Quizzes
- Heartburn Slideshow: Foods to Eat, Foods to Avoid
- Digestive Disease Myths
- Take the GERD Quiz
- What is lansoprazole, and how does it work (mechanism of action)?
- What brand names are available for lansoprazole?
- Is lansoprazole available as a generic drug?
- Do I need a prescription for lansoprazole?
- What are the side effects of lansoprazole?
- What is the dosage for lansoprazole?
- Which drugs or supplements interact with lansoprazole?
- Is lansoprazole safe to take if I'm pregnant or breastfeeding?
- What else should I know about lansoprazole?
What is lansoprazole, and how does it work (mechanism of action)?
Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome that are caused by stomach acid. Lansoprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal.
What brand names are available for lansoprazole?
Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid 24HR, Prevacid, Prevacid SoluTab
What are the side effects of lansoprazole?
Lansoprazole like other PPIs is well-tolerated. The most common side effects are:
Other important side effects include:
Proton pump inhibitors may increase the risk of Clostridium difficile infection. High doses and long-term use (1 year or longer) may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine. Prolonged use also reduces absorption of vitamin B12 (cyanocobalamin).
Long-term use of PPIs has also been associated with low levels of magnesium (hypomagnesemia). Analysis of patients taking PPIs for long periods of time showed an increased risk of heart attacks.
Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated.
Quick GuideHeartburn: Causes, Symptoms, Remedies, Treatments
What is the dosage for lansoprazole?
For initial treatment of duodenal ulcers the recommended dose for adults is 15 mg daily for 4 weeks.
For the treatment of GERD, the recommended initial treatment is 15 mg for up to 8 weeks.
For maintaining healing (long-term) in duodenal ulcer and GERD the recommended treatment is 15 mg daily.
For the management of Zollinger-Ellison Syndrome, the starting dose for adults is 60 mg daily, and the dose is adjusted based on response. Doses up to 180 mg have been used in some patients with Zollinger-Ellison syndrome.
Intravenous lansoprazole is approved for patients who are unable to take oral lansoprazole. The approved intravenous dose is 30 mg daily for up to 7 days.
It is recommended that capsules be taken before meals for maximum effect. Capsules should be swallowed whole and should not be crushed, split or chewed.
For those with difficulty swallowing, the capsule should be opened and the granular contents sprinkled on a tablespoon of apple sauce, ENSURE pudding, cottage cheese, yogurt or strained pears and swallowed immediately. Granules also may be mixed in two ounces (60 ml) of apple, orange or tomato juice and swallowed immediately. For patients with a nasogastic tube, mix the granules can be mixed in two ounces of apple juice and injected through the nasogastric tube.
Which drugs or supplements interact with lansoprazole?
Lansoprazole is less likely than omeprazole (Prilosec, Zegerid) to interact with other drugs.
The absorption of certain drugs may be affected by stomach acidity, and, as a result, lansoprazole and other PPIs that reduce stomach acid also reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, respectively.
Is lansoprazole safe to take if I'm pregnant or breastfeeding?
Use of lansoprazole in pregnant women has not been adequately evaluated.
Lansoprazole has not been studied in nursing women.
What else should I know about lansoprazole?
What preparations of lansoprazole are available?
Capsules: 15 and 30 mg. Oral suspension: in 15 and 30 mg unit dose cartons of 30. Lansoprazole also is available in 15 and 30 mg tablets that disintegrate when placed under the tongue (Prevacid SoluTab). Lansoprazole is available for intravenous injection in vials containing 30 mg of powdered lansoprazole (30 mg/5 ml when mixed with sterile water).
How should I keep lansoprazole stored?
Store at room temperature between 15 C and 30 C (59 F and 86 F). Keep away from moisture.
Reference: FDA Prescribing Information
Quick GuideHeartburn: Causes, Symptoms, Remedies, Treatments
Daily Health News
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
- lansoprazole (Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid 24) Related Diseases
- lansoprazole (Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid 24) Images & Quizzes
- lansoprazole (Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid 24) Index
Top lansoprazole Related ArticlesComplete List
Abdominal Pain PicturesGet the facts on the most common causes of abdominal pain. Learn the difference between a stomachache and more serious causes of abdominal pain. Diagnosis of abdominal pain is based on symptoms and the location of pain, like sharp pain in the lower abdomen.
Digestive Myths PicturesLearn about the digestive system and common misconceptions of digestive disorders. Read about what causes ulcers, heartburn, constipation, and more.
Indigestion (dyspepsia) can be caused by diseases or conditions that involve the gastrointestinal (GI) tract, and also by some diseases and conditions that do not involve the GI tract. Indigestion can be a chronic condition in which the symptoms fluctuate infrequency and intensity. Signs and symptoms that accompany indigestion include:
- Upper abdominal pain
- Abdominal bloating and distention
- Feeling full after eating only a small portion of food
Home remedies, medication, and lifestyle changes can help relieve and cure indigestion and its associated symptoms.
Esophageal pH MonitoringEsophageal pH monitoring is a procedure for measuring the reflux (regurgitation or backwash) of acid from the stomach into the esophagus. The Esophageal pH test is used to diagnose gastroesophageal reflux disease (GERD) and to determine if the acid is responsible for symptoms such as:
- and sore throat.
Esophagitis is caused by an infection or irritation of the esophagus. Infections that cause esophagitis include candida yeast infection of the esophagus as well as herpes. Signs and symptoms of esophagitis include:
- Mouth sores
- Chest pain
- Bad breath
- Sore throat
- Difficulty swallowing
Treatment of esophagitis includes diet, lifestyle changes, and medication depending upon the cause.
Esophagus PictureThe esophagus is a muscular tube connecting the throat (pharynx) with the stomach. See a picture of the Esophagus and learn more about the health topic.
GastritisGastritis is an inflammation of the stomach lining. Causes of gastritis include drinking too much alcohol, medications such as NSAIDs, ibuprofen, aspirin, H. pylori infection, severe infections, burns, anemia, and autoimmune disorders. Gastritis is diagnosed with endoscopy, blood tests, or stool tests. Treatment depends upon the cause of gastritis.
Gastroesophageal Reflux Disease (GERD)GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the esophagus. The symptoms of uncomplicated GERD are:
- regurgitation, and
Take the GERD QuizWho is at risk for developing GERD? Are you? Take this quiz to learn what GERD is, if you're at risk, and what you can do about it.
Heartburn (Reflux)Heartburn is a burning sensation experienced from acid reflux (GERD). Symptoms of heartburn include
- chest pain,
- burning in the throat,
- difficulty swallowing,
- the feeling of food sticking in the throat, and
- a burning feeling in the chest.
- dietary habits,
- lifestyle habits, and
- medical causes.
- lifestyle changes,
- OTC medication,
- prescription medication, and
Heartburn Foods SlidesLearn the symptoms of heartburn and which foods cause heartburn or GERD. Discover home remedies and which foods may provide treatment for heartburn relief.
Helicobacter PyloriHelicobacter pylori (H. pylori) is a bacteria that causes chronic inflammation (gastritis) of the inner lining of the stomach, and also is the most common cause of ulcers worldwide. About 50% of people in the world carries or is infected with H. pylori. Common symptoms of H. pylori infection are occasional abdominal discomfort, bloating, belching or burping, and nausea and vomiting. H. pylori infection is difficult to erdicate, and treatment is with two or more antibiotics.
OsteoporosisLearn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone fracture. Unless one experiences a fracture, a person may have osteoporosis for decades without knowing it. Treatment for osteoporosis may involve medications that stop bone loss and increase bone strength and bone formation, as well as quitting smoking, regular exercise, cutting back on alcohol intake, and eating a calcium- and vitamin D-rich balanced diet.
Peptic or stomach ulcers are ulcers are an ulcer in the lining of the stomach, duodenum, or esophagus. Ulcer formation is related to H. pylori bacteria in the stomach, use of anti-inflammatory medications, and cigarette smoking. Symptoms of peptic or stomach ulcers include:
- Abdominal burning or hunger pain
- Abdominal discomfort after meals
Treatment for stomach ulcers depends upon the cause.
SclerodermaScleroderma is an autoimmune disease of the connective tissue. It is characterized by the formation of scar tissue (fibrosis) in the skin and organs of the body, leading to thickness and firmness of involved areas. Scleroderma is also referred to as systemic sclerosis, and the cause is unknown. Treatment of scleroderma is directed toward the individual features that are most troubling to the patient.