- What is lansoprazole, and how does it work (mechanism of action)?
- What brand names are available for lansoprazole?
- Is lansoprazole available as a generic drug?
- Do I need a prescription for lansoprazole?
- What are the side effects of lansoprazole?
- What is the dosage for lansoprazole?
- Which drugs or supplements interact with lansoprazole?
- Is lansoprazole safe to take if I'm pregnant or breastfeeding?
- What else should I know about lansoprazole?
What is lansoprazole, and how does it work (mechanism of action)?
Proton pump inhibitors are used for the treatment of conditions such as ulcers, gastroesophageal reflux disease (GERD) and Zollinger-Ellison syndrome that are caused by stomach acid. Lansoprazole, like other proton-pump inhibitors, blocks the enzyme in the wall of the stomach that produces acid. By blocking the enzyme, the production of acid is decreased, and this allows the stomach and esophagus to heal.
What brand names are available for lansoprazole?
Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid 24HR, Prevacid, Prevacid SoluTab
What are the side effects of lansoprazole?
Lansoprazole like other PPIs is well-tolerated. The most common side effects are:
Other important side effects include:
Proton pump inhibitors may increase the risk of Clostridium difficile infection. High doses and long-term use (1 year or longer) may increase the risk of osteoporosis-related fractures of the hip, wrist, or spine. Prolonged use also reduces absorption of vitamin B12 (cyanocobalamin).
Long-term use of PPIs has also been associated with low levels of magnesium (hypomagnesemia). Analysis of patients taking PPIs for long periods of time showed an increased risk of heart attacks.
Therefore, it is important to use the lowest doses and shortest duration of treatment necessary for the condition being treated.
What is the dosage for lansoprazole?
For initial treatment of duodenal ulcers the recommended dose for adults is 15 mg daily for 4 weeks.
For the treatment of GERD, the recommended initial treatment is 15 mg for up to 8 weeks.
For maintaining healing (long-term) in duodenal ulcer and GERD the recommended treatment is 15 mg daily.
For the management of Zollinger-Ellison Syndrome, the starting dose for adults is 60 mg daily, and the dose is adjusted based on response. Doses up to 180 mg have been used in some patients with Zollinger-Ellison syndrome.
Intravenous lansoprazole is approved for patients who are unable to take oral lansoprazole. The approved intravenous dose is 30 mg daily for up to 7 days.
It is recommended that capsules be taken before meals for maximum effect. Capsules should be swallowed whole and should not be crushed, split or chewed.
For those with difficulty swallowing, the capsule should be opened and the granular contents sprinkled on a tablespoon of apple sauce, ENSURE pudding, cottage cheese, yogurt or strained pears and swallowed immediately. Granules also may be mixed in two ounces (60 ml) of apple, orange or tomato juice and swallowed immediately. For patients with a nasogastic tube, mix the granules can be mixed in two ounces of apple juice and injected through the nasogastric tube.
Which drugs or supplements interact with lansoprazole?
Lansoprazole is less likely than omeprazole (Prilosec, Zegerid) to interact with other drugs.
The absorption of certain drugs may be affected by stomach acidity, and, as a result, lansoprazole and other PPIs that reduce stomach acid also reduce the absorption and concentration in blood of ketoconazole (Nizoral) and increase the absorption and concentration in blood of digoxin (Lanoxin). This may lead to reduced effectiveness of ketoconazole or increased digoxin toxicity, respectively.
Is lansoprazole safe to take if I'm pregnant or breastfeeding?
Use of lansoprazole in pregnant women has not been adequately evaluated.
Lansoprazole has not been studied in nursing women.
What else should I know about lansoprazole?
What preparations of lansoprazole are available?
Capsules: 15 and 30 mg. Oral suspension: in 15 and 30 mg unit dose cartons of 30. Lansoprazole also is available in 15 and 30 mg tablets that disintegrate when placed under the tongue (Prevacid SoluTab). Lansoprazole is available for intravenous injection in vials containing 30 mg of powdered lansoprazole (30 mg/5 ml when mixed with sterile water).
How should I keep lansoprazole stored?
Store at room temperature between 15 C and 30 C (59 F and 86 F). Keep away from moisture.
Subscribe to MedicineNet's General Health Newsletter
Lansoprazole (Heartburn Relief 24 Hour, Heartburn Treatment 24 Hour, Prevacid 24HR, Prevacid, Prevacid SoluTab) is in a class of drugs called PPIs (proton pump inhibitors). Prevacid capsules are available over-the-counter. Other forms of lansoprazole are by prescription only. Lansoprazole is for the treatment of GERD, treating ulcers of the stomach and duodenum, and Zollinger-Ellison syndrome. Side effects, safety information, warnings and precautions and drug interactions should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
What's Causing Your Abdominal Pain?
Get the facts on the most common causes of abdominal pain. Learn the difference between a stomachache and more serious causes of...
GERD Quiz: Test Your Digestive Diseases IQ
Who is at risk for developing GERD? Are you? Take this quiz to learn what GERD is, if you're at risk, and what you can do about...
Heartburn: Foods to Eat, Foods to Avoid
Learn the symptoms of heartburn and which foods cause heartburn or GERD. Discover home remedies and which foods may provide...
Picture of Peptic Ulcer
A hole in the lining of the stomach, duodenum, or esophagus. See a picture of Peptic Ulcer and learn more about the health topic....
Picture of Gastroesophageal Reflux (GERD)
The stomach contents regurgitate and back up (reflux) into the esophagus The food in the stomach is partially digested by...
Picture of Esophagus
The esophagus is a muscular tube connecting the throat (pharynx) with the stomach. See a picture of the Esophagus and learn more...
Digestive Disorders: Common Misconceptions
Learn about the digestive system and common misconceptions of digestive disorders. Read about what causes ulcers, heartburn,...
Related Disease Conditions
H. pylori (Helicobacter Pylori) Infection
Helicobacter pylori (H. pylori) is a bacteria that causes chronic inflammation (gastritis) of the inner lining of the stomach,...
Gastritis Symptoms, Causes, Diet, Home Remedies, Treatment, and Cure
Gastritis (acute and chronic) is an inflammation of the lining of the stomach Some people have no gastritis symptoms, but when...
Esophagitis is caused by an infection or irritation of the esophagus. Infections that cause esophagitis include candida yeast...
Indigestion (Dyspepsia, Upset Stomach Pain) Symptoms, Relief Remedies, Medicine
Indigestion (dyspepsia) can be caused by diseases or conditions that involve the gastrointestinal (GI) tract, and also by some...
Is H. pylori Contagious? Symptoms and Tests
H. pylori (Helicobacter pylori) infection: Is it contagious? H. pylori infection is caused by fecal contamination in either food...
Learn about osteoporosis, a condition characterized by the loss of bone density, which leads to an increased risk of bone...
Peptic Ulcer (Stomach Ulcer)
Peptic or stomach ulcers are ulcers are an ulcer in the lining of the stomach, duodenum, or esophagus. Ulcer formation is related...
GERD (Acid Reflux, Heartburn)
GERD (gastroesophageal reflux disease) is a condition in which the acidified liquid contents of the stomach backs up into the...
Heartburn is a burning sensation experienced from acid reflux (GERD). Symptoms of heartburn include chest pain, burning in the...
Reflux Laryngitis (Diet, Home Remedies, Medicine)
Reflux laryngitis is caused by acid refluxing back up through the esophagus and voice box. Reflux laryngitis causes irritation...
Barrett's esophagus occurs as a complication of chronic gastroesophageal reflux disease (GERD), primarily in white males. GERD...
Scleroderma is an autoimmune disease of the connective tissue. It is characterized by the formation of scar tissue (fibrosis) in...
Eosinophilic esophagitis is an inflammation of the esophagus. Eosinophilic esophagitis has many causes including acid reflux,...
Nonsteroidal Anti-inflammatory Drugs and Ulcers
Nonsteroidal antiinflammatory drugs (NSAIDs) are prescribed medications for the treatment of inflammatory conditions. Examples of...
Heartburn vs. Acid Reflux (Differences and Similarities)
Heartburn and acid reflux are not the same thing. Heartburn is actually a symptom of acid reflux. Heartburn gets its name...
GERD and GER (Acid Reflux) in Infants and Children
GERD (gastroesophageal reflux disease) is the upward movement of stomach content, including acid, into the esophagus and...
Treatment & Diagnosis
- GERD Gastroesophageal Reflux Disease FAQs
- Medication Disposal
- Dangers of Mixing Medications
- Ulcers May Be Caused By Your Cat
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Ulcers: What Causes Ulcers?
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
- Could Common Heartburn Drugs Up Stroke Risk?
- FAQ: Heartburn Meds and Health Risks
- Could Popular Heartburn Drugs Upset Your 'Good' Gut Bugs?
- Chronic Heartburn May Raise Odds for Throat Cancer: Study
- Heartburn Meds May Often Be Taken for Too Long, at Too-High Doses
- Prescription Drugs for Kids: What's Up, Down
- Heartburn Meds Won't Help, May Harm Kids With Asthma
- Anti-Reflux Drugs, Antibiotics May Raise C. diff Risk
- Some Acid Reflux Drugs Linked to C. diff
- Study: Stomach Acid Drugs Linked to Fracture Risk
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information