Combivir (lamivudine and zidovudine)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

HIV/AIDS Myths and Facts

What brand names are available for lamivudine and zidovudine?

Combivir

Is lamivudine and zidovudine available as a generic drug?

GENERIC AVAILABLE: Yes.

Do I need a prescription for lamivudine and zidovudine?

Yes.

What are the uses for lamivudine and zidovudine?

  • Combivir is used, in combination with other agents, for the treatment of HIV infection.

What are the side effects of lamivudine and zidovudine?

The most serious side effects of Combivir are

Other side effects include

Accumulation or redistribution of fat also may occur.

Quick GuideHIV AIDS Facts: Symptoms and Treatments

HIV AIDS Facts: Symptoms and Treatments

What is the dosage for lamivudine and zidovudine?

  • or the treatment of HIV infection the recommended oral dose for adults or children weighing 30 kg or more is one tablet twice daily.
  • Combivir is administered without regard to meals since food does not affect its absorption.

Which drugs or supplements interact with lamivudine and zidovudine?

  • Fluconazole (Diflucan), probenecid, trimethoprim (Trimpex) and valproic acid (Depakote) reduce the elimination of zidovudine and therefore increase the concentration in blood of zidovudine. This can lead to increased side effects from zidovudine.
  • Lamivudine and zalcitabine (Hivid) reduce the action of one another. Therefore Combivir should not be combined with zalcitabine. Stavudine (Zerit) or doxorubicin reduce the activity of zidovudine and should not be combined with Combivir.
  • Combining zidovudine with ganciclovir (Cytovene), interferon alfa, ribavirin (Rebetol), or other drugs that suppress bone marrow production of blood cells increases the effect of zidovudine on production of blood cells.

Is lamivudine and zidovudine safe to take if I'm pregnant or breastfeeding?

  • Use of Combivir during pregnancy has not been adequately evaluated. However, use of zidovudine by HIV infected women reduces the transmission of HIV to the baby.
  • Use of Combivir by nursing mothers has not been studied. Lamivudine and zidovudine are excreted in breast milk. HIV infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected.

What else should I know about lamivudine and zidovudine?

What preparations of lamivudine and zidovudine are available?

Tablets: 150/300 mg (lamivudine/zidovudine)

How should I keep lamivudine and zidovudine stored?

The tablets should be stored at 2 C to 30 C (36 F to 86 F).

Reference: FDA Prescribing Information

Quick GuideHIV AIDS Facts: Symptoms and Treatments

HIV AIDS Facts: Symptoms and Treatments

Summary

Combivir (lamivudine and zidovudine) is a drug that is used in combination with other agents to treat HIV infection. Serious side effects include:

Drug interactions, and dosage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

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Reviewed on 9/20/2016
References
Reference: FDA Prescribing Information

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