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- What what is lamivudine and zidovudine, and what is it used for?
- What are the side effects of lamivudine and zidovudine?
- What is the dosage for lamivudine and zidovudine?
- Which drugs or supplements interact with lamivudine and zidovudine?
- Is lamivudine and zidovudine safe to take if I'm pregnant or breastfeeding?
- What else should I know about lamivudine and zidovudine?
What what is lamivudine and zidovudine, and what is it used for?
- Combivir is used, in combination with other agents, for the treatment of HIV infection.
What brand names are available for lamivudine and zidovudine?
Is lamivudine and zidovudine available as a generic drug?
Do I need a prescription for lamivudine and zidovudine?
What are the side effects of lamivudine and zidovudine?
The most serious side effects of Combivir are
- a decrease in blood cells,
- muscle pain (myopathy),
- muscle breakdown (rhabdomyolysis),
- liver enlargement,
- immune reconstitution syndrome,
- exacerbation of hepatitis B,
- fatty liver,
- hypersensitivity reactions, and
- metabolic disturbance (lactic acidosis).
Other side effects include
- abdominal pain,
- nausea and vomiting,
- weight loss,
- cough, and
Accumulation or redistribution of fat also may occur.
What is the dosage for lamivudine and zidovudine?
- For the treatment of HIV infection, the recommended oral dose for adults or children weighing 30 kg or more is one tablet twice daily.
- Combivir is administered without regard to meals since food does not affect its absorption.
Which drugs or supplements interact with lamivudine and zidovudine?
- Fluconazole (Diflucan), probenecid, trimethoprim (Trimpex) and valproic acid (Depakote) reduce the elimination of zidovudine and therefore increase the concentration in blood of zidovudine. This can lead to increased side effects from zidovudine.
- Lamivudine and zalcitabine (Hivid) reduce the action of one another. Therefore Combivir should not be combined with zalcitabine. Stavudine (Zerit) or doxorubicin reduce the activity of zidovudine and should not be combined with Combivir.
- Combining zidovudine with ganciclovir (Cytovene), interferon alfa, ribavirin (Rebetol), or other drugs that suppress bone marrow production of blood cells increases the effect of zidovudine on production of blood cells.
Is lamivudine and zidovudine safe to take if I'm pregnant or breastfeeding?
- Use of Combivir during pregnancy has not been adequately evaluated. However, use of zidovudine by HIV infected women reduces the transmission of HIV to the baby.
- Use of Combivir by nursing mothers has not been studied. Lamivudine and zidovudine are excreted in breast milk. HIV infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected.
What else should I know about lamivudine and zidovudine?
What preparations of lamivudine and zidovudine are available?
Tablets: 150/300 mg (lamivudine/zidovudine)
How should I keep lamivudine and zidovudine stored?
The tablets should be stored at 2 C to 30 C (36 F to 86 F).
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Daily Health News
Combivir (lamivudine and zidovudine) is a drug that is used in combination with other agents to treat HIV infection. Serious side effects include fatty liver, pancreatitis, liver enlargement, rhabdomyolysis, lactic acidosis. Drug interactions, and dosage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
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Human Immunodeficiency Virus (HIV)
HIV (human immunodeficiency virus) infection left untreated causes AIDS (acquired immunodeficiency syndrome). Still incurable, AIDS describes immune system collapse that opens the way for opportunistic infections and cancers to kill the patient. Early symptoms and signs of HIV infection include flu-like symptoms and fungal infections, but some people may not show any symptoms for years. Highly active antiretroviral therapy (ART) is the standard treatment for HIV infection. These combination drug regimens have made HIV much less deadly, but a cure or vaccine for the pandemic remains out of reach. HIV is usually transmitted through sexual contact or sharing IV drug needles, but can also infect someone through contact with infected blood. Sexual abstinence, safe sex practices, quitting IV drugs (or at least using clean needles), and proper safety equipment by clinicians and first responders can drastically reduce transmission rates for HIV/AIDS.
AIDS (Acquired Immunodeficiency Syndrome)
AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci, tuberculosis, toxoplasmosis, seizures, weakness, meningitis, yeast infection of the esophagus, and Kaposi's sarcoma. Anti-retroviral therapy (HAART) is used in the treatment of AIDS.
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Medications & Supplements
- Retrovir (zidovudine, ZDV, formerly called AZT)
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- didanosine (Videx, Videx EC)
- delavirdine (Rescriptor)
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- zalcitabine, Hivid - discontinued
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