Medically Reviewed on 9/1/2023

Brand Name: Combivir

Generic Name: lamivudine and zidovudine

Drug Class: Antivirals, Other

What is Combivir, and what is it used for?

Combivir is used, in combination with other agents, for the treatment of HIV infection.

What are the side effects of Combivir?

The most serious side effects of Combivir are

Other side effects include

Accumulation or redistribution of fat also may occur.

What is the dosage for Combivir?

  • For the treatment of HIV infection, the recommended oral dose for adults or children weighing 30 kg or more is one tablet twice daily.
  • Combivir is administered without regard to meals since food does not affect its absorption.

What drugs interact with Combivir?

  • Fluconazole (Diflucan), probenecid, trimethoprim (Trimpex) and valproic acid (Depakote) reduce the elimination of zidovudine and therefore increase the concentration in blood of zidovudine. This can lead to increased side effects from zidovudine.
  • Lamivudine and zalcitabine (Hivid) reduce the action of one another. Therefore Combivir should not be combined with zalcitabine. Stavudine (Zerit) or doxorubicin reduce the activity of zidovudine and should not be combined with Combivir.
  • Combining zidovudine with ganciclovir (Cytovene), interferon alfa, ribavirin (Rebetol), or other drugs that suppress bone marrow production of blood cells increases the effect of zidovudine on production of blood cells.


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Pregnancy and breastfeeding

  • Use of Combivir during pregnancy has not been adequately evaluated. However, use of zidovudine by HIV infected women reduces the transmission of HIV to the baby.
  • Use of Combivir by nursing mothers has not been studied. Lamivudine and zidovudine are excreted in breast milk. HIV infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected.

What else should I know about Combivir?

What preparations of lamivudine and zidovudine are available?

Tablets: 150/300 mg (lamivudine/zidovudine)

How should I keep lamivudine and zidovudine stored?

The tablets should be stored at 2 C to 30 C (36 F to 86 F).


Combivir is a drug that is used in combination with other agents to treat HIV infection. Serious side effects include fatty liver, pancreatitis, liver enlargement, rhabdomyolysis, lactic acidosis. Drug interactions, and dosage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.

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Medically Reviewed on 9/1/2023
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