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- What what is lamivudine and zidovudine, and what is it used for?
- What are the side effects of lamivudine and zidovudine?
- What is the dosage for lamivudine and zidovudine?
- Which drugs or supplements interact with lamivudine and zidovudine?
- Is lamivudine and zidovudine safe to take if I'm pregnant or breastfeeding?
- What else should I know about lamivudine and zidovudine?
What what is lamivudine and zidovudine, and what is it used for?
- Combivir is used, in combination with other agents, for the treatment of HIV infection.
What brand names are available for lamivudine and zidovudine?
Is lamivudine and zidovudine available as a generic drug?
Do I need a prescription for lamivudine and zidovudine?
What are the side effects of lamivudine and zidovudine?
The most serious side effects of Combivir are
- a decrease in blood cells,
- muscle pain (myopathy),
- muscle breakdown (rhabdomyolysis),
- liver enlargement,
- immune reconstitution syndrome,
- exacerbation of hepatitis B,
- fatty liver,
- hypersensitivity reactions, and
- metabolic disturbance (lactic acidosis).
Other side effects include
- abdominal pain,
- nausea and vomiting,
- weight loss,
- cough, and
Accumulation or redistribution of fat also may occur.
What is the dosage for lamivudine and zidovudine?
- For the treatment of HIV infection, the recommended oral dose for adults or children weighing 30 kg or more is one tablet twice daily.
- Combivir is administered without regard to meals since food does not affect its absorption.
Which drugs or supplements interact with lamivudine and zidovudine?
- Fluconazole (Diflucan), probenecid, trimethoprim (Trimpex) and valproic acid (Depakote) reduce the elimination of zidovudine and therefore increase the concentration in blood of zidovudine. This can lead to increased side effects from zidovudine.
- Lamivudine and zalcitabine (Hivid) reduce the action of one another. Therefore Combivir should not be combined with zalcitabine. Stavudine (Zerit) or doxorubicin reduce the activity of zidovudine and should not be combined with Combivir.
- Combining zidovudine with ganciclovir (Cytovene), interferon alfa, ribavirin (Rebetol), or other drugs that suppress bone marrow production of blood cells increases the effect of zidovudine on production of blood cells.
Is lamivudine and zidovudine safe to take if I'm pregnant or breastfeeding?
- Use of Combivir during pregnancy has not been adequately evaluated. However, use of zidovudine by HIV infected women reduces the transmission of HIV to the baby.
- Use of Combivir by nursing mothers has not been studied. Lamivudine and zidovudine are excreted in breast milk. HIV infected mothers should not breast feed because of the potential risk of transmitting HIV to an infant that is not infected.
What else should I know about lamivudine and zidovudine?
What preparations of lamivudine and zidovudine are available?
Tablets: 150/300 mg (lamivudine/zidovudine)
How should I keep lamivudine and zidovudine stored?
The tablets should be stored at 2 C to 30 C (36 F to 86 F).
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Combivir (lamivudine and zidovudine) is a drug that is used in combination with other agents to treat HIV infection. Serious side effects include fatty liver, pancreatitis, liver enlargement, rhabdomyolysis, lactic acidosis. Drug interactions, and dosage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
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Second Source article from Government
AIDS (Acquired Immunodeficiency Syndrome)
AIDS is the advanced stage of HIV infection. Symptoms and signs of AIDS include pneumonia due to Pneumocystis jiroveci, tuberculosis, toxoplasmosis, seizures, weakness, meningitis, yeast infection of the esophagus, and Kaposi's sarcoma. Anti-retroviral therapy (HAART) is used in the treatment of AIDS.
Human Immunodeficiency Virus (HIV)
HIV (human immunodeficiency virus) infection left untreated causes AIDS (acquired immunodeficiency syndrome). The human immunodeficiency virus (HIV) is a type of virus called a retrovirus, which can infect humans when it comes in contact with tissues that line the vagina, anal area, mouth, or eyes, or through a break in the skin. HIV infection is generally a slowly progressive disease in which the virus is present throughout the body at all stages of the disease. Three stages of HIV infection have been described. The initial stage of infection (primary infection), which occurs within weeks of acquiring the virus, often is characterized by the flu- or mono-like illness that generally resolves within weeks. The stage of chronic asymptomatic infection (meaning a long duration of infection without symptoms) lasts an average of eight to 10 years without treatment. The stage of symptomatic infection, in which the body's immune (or defense) system has been suppressed and complications have developed, is called the acquired immunodeficiency syndrome (AIDS). The symptoms are caused by the complications of AIDS, which include one or more unusual infections or cancers, severe loss of weight, and intellectual deterioration (called dementia). When HIV grows (that is, by reproducing itself), it acquires the ability to change (mutate) its own structure. These mutations enable the virus to become resistant to previously effective drug therapy. The goals of drug therapy are to prevent damage to the immune system by the HIV virus and to halt or delay the progress of the infection to symptomatic disease. Therapy for HIV includes combinations of drugs that decrease the growth of the virus to such an extent that the treatment prevents or markedly delays the development of viral resistance to the drugs. The best combination of drugs for HIV are those that effectively suppress viral replication in the blood and also are well tolerated and simple to take so that people can take the medications consistently without missing doses.
Treatment & Diagnosis
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Medications & Supplements
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- Retrovir (zidovudine, ZDV, formerly called AZT)
- abacavir, Ziagen
- lamivudine (3tc) (Epivir; Epivir HBV)
- What Are NRTIs in Antiretroviral Therapy For HIV Infection?
- efavirenz (Sustiva)
- Triumeq (abacavir, dolutegravir, and lamivudine)
- Temixys (lamivudine and tenofovir disoproxil fumarate)
- Dovato (dolutegravir and lamivudine)
- delavirdine (Rescriptor)
- didanosine (Videx, Videx EC)
- stavudine (Zerit)
- abacavir, lamivudine, zidovudine (Trizivir)
- Side Effects of Combivir (lamivudine and zidovudine)
- nevirapine (Viramune, Viramune XR)
Prevention & Wellness
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.