Lamisil Cream vs. Lotrimin: What's the difference?

What is Lamisil cream? What is Lotrimin?

SLIDESHOW

Nail Disorders: What Nails Say About Your Health See Slideshow

What are the side effects of Lamisil and Lotrimin?

Lamisil side effects

The most common side effects of terbinafine are:

Oral terbinafine can cause liver failure sometimes leading to liver transplantation or death.

Lotrimin side effects

The most commonly noted side effects associated with clotrimazole include:

  • local redness,
  • stinging,
  • blistering,
  • peeling,
  • swelling,
  • itching,
  • hives, or
  • burning at the area of application.

Other side effects include nausea and vomiting, which may be caused by the oral forms.

What is the dosage of Lamisil vs. Lotrimin?

Lamisil dosage

  • Tablets: The usual dose is 250 mg once daily for 6 weeks for treatment of the fingernails, and 12 weeks for treatment of toenails. Optimal results will not be seen for several months after treatment because it takes time for new healthy nails to grow. Terbinafine may be taken with or without food.
  • Cream, gel, spray, solution: Apply to affected area (s) once (jock itch, ringworm) or twice daily (athletes foot) for about for 1 week.

Lotrimin dosage

  • The troche (lozenge) should slowly dissolve in the mouth. One troche is administered 5 times daily for 14 days. Clotrimazole cream, lotion, or solution is applied to the affected and surrounding skin areas, generally twice daily in the morning and evening.
  • The vaginal cream is inserted via applicator once daily, preferably at night, for 7 consecutive days.
  • The 100 mg vaginal suppository is inserted once daily, preferably at bedtime, for 7 consecutive days.
  • The 200 mg vaginal suppository is inserted once daily for 3 days, preferably at bedtime.

What drugs interact with Lamisil and Lotrimin?

Lamisil drug interactions

  • Rifampin reduces oral terbinafine blood concentrations, potentially reducing the efficacy of terbinafine. Cimetidine (Tagamet) may increase oral terbinafine blood levels, potentially increasing side effects of terbinafine. Fluconazole (Diflucan) increases the blood levels of oral terbinafine by 52%-69%. Potentially leading to increased side effects.

Lotrimin drug interactions

Are Lamisil and Lotrimin safe to use while pregnant or breastfeeding?

Lamisil

Lotrimin

  • Clotrimazole is very poorly absorbed into the blood and the body after application to the skin or the vagina. Studies in women in their second or third trimesters of pregnancy have demonstrated no ill effects. No data is available in pregnant women during their first trimester. Rats given large amounts of clotrimazole via the vagina have demonstrated no ill effects. The oral troche has not been adequately evaluated in pregnant women.
  • It is not known if clotrimazole is secreted in breast milk.

Subscribe to MedicineNet's General Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Summary

Lamisil Cream (terbinafine) and Lotrimin (clotrimazole) are antifungal agents applied to the skin used to treat fungal nails, jock itch, and athlete's foot. Other forms of Lotrimin are also used to treat vaginal yeast infections, oral thrush, tinea versicolor, or tinea corporis. Side effects of Lamisil Cream and Lotrimin that are similar include itching and hives at the application site.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

Health Solutions From Our Sponsors

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 8/10/2022
References
FDA Prescribing Information