- Side Effects
- Drug Interactions
- Pregnancy & Breastfeeding
- What Else to Know
Generic Name: labetalol
Brand Names: Normodyne, Trandate
Drug Class: Beta-Blockers, Alpha Activity
What is labetalol, and what is it used for?
Labetalol is a drug used for treating high blood pressure (hypertension) and is related to carvedilol (Coreg). Nerves from the adrenergic nervous system travel from the spinal cord to arteries where they release norepinephrine. Norepinephrine attaches to adrenergic receptors on arteries and causes the arteries to contract, narrowing the arteries, and increasing blood pressure. Labetalol blocks receptors of the adrenergic nervous system. When labetalol attaches to and blocks the receptors, arteries expand, resulting in a fall in blood pressure. The FDA approved labetalol in August 1984.
What are the side effects of labetalol?
The most common side effects of labetalol are:
Postural hypotension (a rapid decrease in blood pressure when going from the lying or seated position to the standing position that may cause light-headedness or fainting) occurs rarely. Patients should be observed for this possible side effect within two to four hours of the first labetalol dose and after any changes in dose.
Other important side effects include:
What is the dosage for labetalol?
- The recommended starting oral dose of labetalol is 100 mg twice daily, and the dose can be increased by 100 mg twice daily every 2-3 days based on the response of the blood pressure.
- Usual maintenance doses are 200-400 mg twice daily. Patients with severely high blood pressure may require 1.2 to 2.4 g daily.
- Side effects may be less if labetalol is given in three daily doses rather than two.
- Stopping or changing the dose of the drug should be directed by a physician because serious side effects may occur.
- The initial intravenous dose of labetalol is 20 mg injected over 2 minutes.
- Additional injections of 40 or 80 mg may be administered every 10 minutes as needed up to a total dose of 300 mg.
- Labetalol also may be administered by intravenous infusion at 1-2 mg/minute.
What drugs interact with labetalol?
- Labetalol can mask early warning symptoms of hypoglycemia (low blood sugar) such as tremors and increased heart rate, which are the result of activation of the adrenergic nervous system. Therefore, people with diabetes taking medications that lower blood sugar such as insulin or oral antidiabetic medications may need to increase the frequency with which they monitor their blood sugar in order to prevent hypoglycemia.
- Combining labetalol with tricyclic antidepressants such as amitriptyline (Elavil, Endep), imipramine (Tofranil), or nortriptyline (Pamelor) may lead to an increase in tremor which is a side effect of tricyclic antidepressants.
- If combined with adrenergic stimulating drugs used for treating asthma, for example, albuterol (Proventil, Ventolin) or pirbuterol (Maxair), the adrenergic blocking effects of labetalol may counteract the effects of the stimulating drugs and reduce their effectiveness for treating asthmatic attacks. More of the adrenergic drug may be needed.
- Glutethimide (Doriden) may decrease the effectiveness of labetalol by increasing its elimination. When both drugs are used together, more labetalol or less glutethimide may be needed.
- Cimetidine (Tagamet) may increase the effectiveness of labetalol by blocking its elimination and increasing its levels in the blood. Therefore, less labetalol may be needed when cimetidine and labetalol are used together.
- Halothane anesthesia may contribute to the blood pressure lowering effects of labetalol.
Is labetalol safe to take if I'm pregnant or breastfeeding?
Labetalol is a medication prescribed for the treatment of high blood pressure. The most common side effects of labetalol are fatigue, dizziness, nausea, headache, diarrhea, edema (fluid accumulation), and shortness of breath. Other important side effects include sexual dysfunction, abnormal heart rhythm, slow heart rate, liver failure, and allergic reactions. Consult your doctor before taking if pregnant or breastfeeding.
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Blood Pressure Readings: Chart, Normal, High, Low
Blood pressure is the force applied by the blood over the inner walls of the arteries. Although the average blood pressure for a person remains constant, it shows minor fluctuations throughout the day—declining while relaxing and momentarily increasing while being excited or under stress. An increase in resting blood pressure can scar, stiffen, or harden the arteries.
Why Is My Bottom Blood Pressure Number High?
Isolated diastolic hypertension (IDH) occurs when your systolic blood pressure is normal, and only your diastolic blood pressure is high (over 80 mm Hg). Causes of high diastolic blood pressure include a high-sodium diet, obesity, lack of physical activity, excessive alcohol consumption, stress and anxiety.
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
How Can I Lower My Blood Pressure in Minutes?
Learn how to lower your high blood pressure quickly and how to better manage this condition.
What Is Normal Blood Pressure and Pulse by Age?
The American Heart Association outlines that a normal blood pressure reading of 120/80 mm Hg for adults. Here is a chart that breaks down the ideal blood pressure range by age.
What Does it Mean When the Bottom Number of Your Blood Pressure is Over 100?
Diastolic blood pressure (DBP) is the pressure exerted on the walls of the arteries when the heart muscle relaxes between beats. When the bottom number of blood pressure (diastole) is over 100 mmHg, it may be called diastolic hypertension (DHT). Diastolic blood pressure means the blood pressure reading during the phase when your heart relaxes (diastole). Force of the blood against the walls of the arteries (the blood vessels carrying blood from the heart to other sites) in the body is called blood pressure. The heart pumps the blood into the arteries as it contracts (systole).
How to Lower My Blood Pressure Immediately
If you face any complications of high blood pressure such as a stroke or heart attack, contact your physician without any delay. Do not attempt home remedies in such grave situations. If you have high blood pressure, without any complications, the first thing to do is to calm down and lie flat.
What Is Considered Stroke-Level High Blood Pressure?
Blood pressure readings above 180/120 mmHg are considered stroke-level and require immediate medical attention. Check out the center below for more medical references on hypertension, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
How Do You Check Your Blood Pressure With Fingers?
Most doctors recommend the use of a blood pressure machine to check blood pressure. An individual may check heart rate with their fingers, but not blood pressure.
Is 120 Over 60 a Good Blood Pressure Reading?
If your systolic blood pressure is normal (between 100-120), and your diastolic blood pressure is lower (60 or below), you are considered to have low blood pressure, or isolated diastolic hypotension. Low diastolic blood pressure should be monitored closely.
What Is the Blood Pressure of a Very Fit Person?
Studies show that a very fit person who exercises regularly will have a lower resting blood pressure (usually below 120/80 mm Hg) than someone who leads a sedentary lifestyle.
Can Blood Pressure Spike For No Reason?
It is normal for your blood pressure to rise and fall throughout the day. Your blood pressure can fluctuate at any time due to various reasons.
Which ACE Inhibitor Is the Best for Hypertension?
The best ACE inhibitors for hypertension include Trandolapril, Enalapril, and Ramipril.
How Is Diastolic Hypertension Treated?
Diastolic hypertension, where only your diastolic blood pressure is elevated, may be treated with lifestyle changes such as weight loss, reducing your sodium intake or alcohol consumption, and quitting smoking. Medications may be prescribed in more severe cases.
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to the heart. Heart disease can lead to heart attack. Risk factors for heart disease include: Smoking High blood pressure High cholesterol Diabetes Family history Obesity Angina, shortness of breath, and sweating are just a few symptoms that may indicate a heart attack. Treatment of heart disease involves control of heart disease risk factors through lifestyle changes, medications, and/or stenting or bypass surgery. Heart disease can be prevented by controlling heart disease risk factors.
Is A Manual Blood Pressure More Accurate?
Manual blood pressure gives accurate results when used correctly by a trained person. However, manual blood pressure measurement is not the recommended type of blood pressure monitoring for home use because it requires some training.
Can You Take Turmeric if You Take Blood Pressure Medicine?
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Which Is More Important: Systolic or Diastolic Blood Pressure?
Systolic blood pressure is often given more attention as a risk factor for heart disease. However, both systolic and diastolic blood pressure are equally important in monitoring the health of your heart.
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Things to Know About High Blood Pressure Treatment
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Is Turmeric OK to Take With High Blood Pressure?
Turmeric is an ancient remedy, a perennial plant in the ginger family. Turmeric may help lower blood pressure, but talk to your doctor if you take medication to make sure it doesn't interact with it.
Can Drinking Water Lower Your Blood Pressure?
Keeping well hydrated by drinking six to eight glasses of water daily (even more if working in hot and humid conditions) is beneficial for the blood pressure. High blood pressure (BP) or hypertension is a condition caused by the persistent high pressure of blood against the walls of arteries. It is also called systolic pressure (constantly greater than 139 mmHg) or diastolic pressure (constantly more than 89 mmHg).
When Is Blood Pressure Lowest and Highest During the Day?
Your blood pressure fluctuates throughout the day. Check your blood pressure twice a day at around the same time every day.
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Lifestyle changes and home remedies are effective in controlling high blood pressure (hypertension). Check out the center below for more medical references on hypertension, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
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Which Blood Pressure Number Is the Most Important?
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Portal hypertension is most commonly caused by cirrhosis, a disease that results from scarring of the liver. Other causes of portal hypertension include blood clots in the portal vein, blockages of the veins that carry the blood from the liver to the heart, and a parasitic infection called schistosomiasis. Symptoms of portal hypertension include varices (enlarged veins), vomiting blood, blood in the stool, black and tarry stool, ascites (abnormal fluid collection within the peritoneum, the sac that contains the intestines within the abdominal cavity), confusion and lethargy, splenomegaly or enlargement of the spleen, and decreased white blood cell counts.
What Are the Top Drinks to Lower Blood Pressure?
The top drinks for lowering blood pressure include beverages that are rich in nutrients and low in sodium and fats. Learn the 10 best blood-pressure-lowering drinks here.
Why Does Alcohol Cause Hypertension?
Alcoholic beverages are regular drinks in most parts of the world. No one knows how alcohol causes hypertension, but it may be due to the effects of alcohol endothelium, nervous system, cortisol levels or other body systems.
Can High Blood Pressure Hurt My Eyes?
Unfortunately, yes. Suffering from untreated or poorly controlled high blood pressure for a long time can be detrimental to your eyes. Several eye diseases are directly or indirectly caused by high blood pressure (hypertension).
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What is high blood pressure, and how do you lower it? Learn the signs of high blood pressure and what to do if your blood pressure numbers go above a healthy range.
What Are Abnormal Blood Pressure Number Ranges?
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What Is Aortic Dissection?
Aortic dissection is a small tear in the large blood vessel that leads from the heart and supplies blood to the body. Symptoms of aortic dissection include a tearing or ripping pain, nausea, sweating, weakness, shortness of breath, sweating, or fainting. Treatment depends on the type of aortic dissection, and the severity of the tear in the aorta.
Can I Check My Blood Pressure With My Phone?
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What Will Happen if Your Blood Pressure is Too High?
High blood pressure, also known as hypertension, can have negative consequences on your health. Learn what happens if your blood pressure is too high, the causes of high blood pressure, and what you can do to treat it.
How Often Should Blood Pressure be Checked?
People older than 40 years should check their blood pressure once a year, while those between 18 and 40 years old should check it every three to five years.
What Are the New Blood Pressure Guidelines for Seniors?
Hypertension or high blood pressure (high BP) is a medical condition where the pressure in the blood vessels is persistently elevated. The heart pumps blood into the arteries, which circulate blood to all parts of the body. In cases of high blood pressure, the heart has to work harder to push the blood column ahead.
What Is High Blood Pressure (Hypertension)?
High blood pressure or hypertension is when the blood pressure readings consistently range from 140 or higher for systolic or 90 or higher for diastolic. Blood pressure readings above 180/120 mmHg are dangerously high and require immediate medical attention.
Is Pseudotumor Cerebri the Same as Intracranial Hypertension?
Pseudotumor cerebri (PTC) is also called idiopathic intracranial hypertension (IIH). The condition causes symptoms similar to a brain tumor.
What Is “Normal” Blood Pressure?
Normal blood pressure is when the pressure is less than or upto 120/80 mmHg. The value 120 denotes the systolic pressure, and the value 80 denotes the diastolic pressure.
What Is a Normal Blood Pressure Check?
A normal blood pressure check should be below 120/80 mmHg in adults (18 years and older).
What Causes High Blood Pressure in Children?
Research states that kidney disease is the main cause of high blood pressure in children; however, here are the other potential causes of hypertension in kids.
What Is the Drug of Choice for Hypertension?
Angiotensin-converting enzyme (ACE) inhibitors are the drug of choice for hypertension. Learn about other high blood pressure medications.
How Does High Blood Pressure Affect Pregnancy?
High blood pressure during pregnancy can cause serious complications. Learn more about the signs of and risks associated with the condition.
What Is the Proper Way to Take Your Blood Pressure?
Nowadays, you can easily measure your blood pressure at home using an automated blood pressure machine or sphygmomanometer. Here’s how to do it step-by-step to make sure you’re doing it the right way.
What BP Is Hypertension?
Hypertension occurs when blood pressure readings are 130/80 mmHg or higher. Learn about blood pressure levels, as well as symptoms, risk factors, and treatment options for high blood pressure. Check out the center below for more medical references on hypertension, including multimedia (slideshows, images, and quizzes), related diseases, treatment, diagnosis, medications, and prevention or wellness.
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Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information