- Tips to Fast Stress Relief
- Take the Panic Attacks Quiz!
- Generalized Anxiety Disorder (GAD) Slideshow
- Clonazepam vs. buspirone: What's the difference?
- What are clonazepam and buspirone?
- What are the side effects of clonazepam and buspirone?
- What is the dosage of clonazepam vs. buspirone?
- What drugs interact with clonazepam and buspirone?
- Are clonazepam and buspirone safe to use while pregnant or breastfeeding?
Clonazepam vs. buspirone: What's the difference?
- Klonopin (clonazepam) and Buspar (buspirone) are used to provide short-term relief of symptoms in the treatment of anxiety.
- Clonazepam is primarily used to treat panic disorder, to prevent certain types of seizures, and to treat Lennox-Gastaut syndrome.
- Buspirone is especially effective in persons with limited to moderate generalized anxiety. It is not very effective in treating severe anxiety, panic disorders, or obsessive-compulsive disorders. Buspirone may also help improve symptoms of depression in patients with generalized anxiety disorder.
- Clonazepam and buspirone are different types of anxiety medications. Clonazepam is a benzodiazepine and buspirone is an anxiolytic unrelated to benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.
- A brand name for clonazepam is Klonopin.
- A brand name for busprione is Buspar.
- Side effects of clonazepam and busprione that are similar include dizziness, headache, weakness, unsteadiness, sleep problems (insomnia), and skin rash.
- Side effects of clonazepam that are different from busprione include sedation, depression, loss of orientation, lack of inhibition, fatigue, amnesia, confusion, changes in sexual desire, and irritability.
- Side effects of busprione that are different from clonazepam include nausea, nervousness, lightheadedness, excitement, diarrhea, hostility, and tremors.
- Suddenly stopping clonazepam after prolonged use can lead to withdrawal symptoms.
What are clonazepam and buspirone?
Clonazepam is a benzodiazepine anti-anxiety medication primarily used for treating panic disorder and preventing certain types of seizures, and for short-term relief of anxiety symptoms. Other benzodiazepines include alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), and flurazepam (Dalmane). Clonazepam and other benzodiazepines enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. Research shows that excessive activity in the brain may lead to anxiety or other psychiatric disorders.
Buspirone is used to manage anxiety disorders and provide short-term relief of the symptoms of anxiety. It is especially effective in persons with limited to moderate generalized anxiety. It is not very effective in persons with severe anxiety, panic disorders, or obsessive-compulsive disorders. Buspirone also may help improve symptoms of depression in patients with generalized anxiety disorder. Its mechanism of action is not clearly understood, but it may work by stimulating serotonin type 1A receptors on nerves, thereby altering the chemical messages that nerves receive. It also has minor effects on dopamine receptors, but this does not contribute much to its action. Unlike benzodiazepines, buspirone does not cause sedation.

SLIDESHOW
A Visual Guide to Generalized Anxiety Disorder See SlideshowWhat are the side effects of clonazepam and buspirone?
Clonazepam
The most common side effects associated with clonazepam are sedation, which is reported in approximately half of patients. Dizziness is reported in one-third of patients.
Other common side effects include:
- A feeling of depression
- Loss of orientation
- Headache
- Weakness
- Unsteadiness
- Sleep disturbance
- Lack of inhibition
- Fatigue
- Amnesia
- Confusion
- Changes in sexual desire
- Rash
- Irritability
Other serious side effects of clonazepam include:
- Respiratory depression
- Fainting
- Enlarged liver
- Withdrawal symptoms (if stopped suddenly)
- Increased heart rate
- Low blood pressure
- Blood disorders
Other serious adverse reactions:
Antiepileptic medications have been associated with an increased risk of suicidal thinking and behavior. Anyone considering the use of antiepileptic drugs must balance this risk of suicide with the clinical need for the antiepileptic drug. Patients who begin antiepileptic therapy should be closely observed for clinical worsening, suicidal thoughts or unusual changes in behavior.
Busprione
The most common side effects associated with buspirone are:
- Dizziness
- Nausea
- Headache
- Nervousness
- Lightheadedness
- Excitement
- Insomnia
Other important but less frequent side effects include:
- Unsteady gait
- Diarrhea
- Excitement
- Weakness
- Hostility
- Skin rash
- Tremors
What is the dosage of clonazepam vs. buspirone?
Clonazepam
The dose of clonazepam is tailored to the patient's needs.
- For seizures in adults, the initial dose is 1.5 mg daily in 3 divided doses.
- Dosage may be increased by 0.5 to 1 mg daily every 3 days until seizures are controlled, or side effects preclude further increases in dose.
- The maximum dose is 20 mg daily.
- The initial dose for panic disorders is 0.25 mg twice daily.
- The dose may be increased to the target dose of 1 mg daily after 3 days.
Buspirone
- The usual starting adult dose of buspirone is 10-15 mg daily given in 2 or 3 doses.
- The dose may be increased by 5 mg every 2 to 4 days until an effective dose is found.
- The maximum adult dose is 60 mg daily, but most patients respond to 15-30 mg daily.
- Although food increases the amount of buspirone that is absorbed, the importance of this effect is not clear.
- Buspirone can be taken with or without food but preferably on a consistent basis.

QUESTION
Panic attacks are repeated attacks of fear that can last for several minutes. See AnswerWhat drugs interact with clonazepam and buspirone?
Clonazepam
Clonazepam, like all other benzodiazepines, accentuates the effects of other drugs that slow the brain's processes -- such as alcohol, barbiturates, and narcotics -- which leads to increased sedation.
Buspirone
Buspirone may interact with drugs called monoamine oxidase (MAO) inhibitors -- such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) -- which are used in psychiatric disorders. The use of buspirone with these drugs can cause increased blood pressure. A similar reaction may occur if buspirone is combined with linezolid (Zyvox), an antibiotic that is also an MAO inhibitor. The combination of buspirone and trazodone (Desyrel), an antidepressant, may cause abnormal liver enzymes in the blood.
The combination of buspirone and warfarin (Coumadin), a blood thinner, may accentuate the effects of warfarin and increase the risk of bleeding. Patients taking buspirone should not drink grapefruit juice, since the juice (even well after a dose of buspirone is taken) can increase the amount of buspirone in the blood, possibly leading to side effects.
Inactivation and removal of buspirone is mediated by liver enzymes. Drugs (for example, erythromycin, itraconazole [Sporanox], nefazodone [Serzone]) that inhibit these liver enzymes increase blood concentrations of buspirone, and drugs (for example, rifampin) that enhance these enzymes decrease blood concentrations of buspirone. Increased blood concentrations may increase side effects while decreased blood concentrations may reduce efficacy.
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Are clonazepam and buspirone safe to use while pregnant or breastfeeding?
Clonazepam
- Clonazepam and other benzodiazepines have been associated with fetal damage, including congenital malformations, when taken by pregnant women in their first trimester. Clonazepam is best avoided in the first trimester and probably throughout pregnancy.
- Benzodiazepines are secreted in breast milk. Mothers who are breastfeeding should not take clonazepam.
Bursprione
- There are no adequate studies of buspirone in pregnant women.
- It is not known if buspirone is secreted in human breast milk. Because buspirone is secreted in the breast milk of animals, however, it should not be used by women who are nursing infants.
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Summary
Klonopin (clonazepam) and Buspar (buspirone) are used to provide short-term relief of symptoms in the treatment of anxiety. Buspirone is especially effective in persons with limited to moderate generalized anxiety, while clonazepam is primarily used to treat panic disorder. Learn about the side effects, recommended dosage of each drug and the main differences between these two different types of anxiety medications.
Multimedia: Slideshows, Images & Quizzes
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A Visual Guide to Generalized Anxiety Disorder
Learn about generalized anxiety disorder (GAD). See if your worries are normal or something more by learning about symptoms,...
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Anxiety, Stress, Worry, and Your Body
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Related Disease Conditions
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Anxiety
Second Source article from WebMD
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Anxiety
Anxiety is a feeling of apprehension and fear characterized by symptoms such as trouble concentrating, headaches, sleep problems, and irritability. Anxiety disorders are serious medical illnesses that affect approximately 19 million American adults. Treatment for anxiety may incorporate medications and psychotherapy.
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Separation Anxiety
Separation anxiety disorder is a common childhood anxiety disorder that has many causes. Infants, children, older kids and adults can suffer from symptoms of separation anxiety disorder. Common separation anxiety treatment methods include therapy and medications. Factors that contribute to how quickly or successfully a child moves past separation anxiety by preschool age include how well the parent and child reunite, the skills the child and adult have at coping with the separation, and how well the adult responds to the infant's separation issues. For example, children of anxious parents tend to be anxious children.
Treatment & Diagnosis
Medications & Supplements
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Anxiety
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Clonazepam (Klonopin) is an prescription medication used to treat panic disorder, certain types of seizures, Lennox-Gastaut syndrome, and the short-term relief of anxiety. Side effects include
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Klonopin (clonazepam) and Restoril (temazepam) are benzodiazepine drugs used for the treatment of anxiety. Klonopin is also used to treat panic disorder, while temazepam is also used to treat insomnia symptoms, such as trouble falling asleep and staying asleep. Learn about the side effects, recommended dosage and main differences between these two anti-anxiety medications.Klonopin (clonazepam) vs. Valium (diazepam)
Klonopin (clonazepam) and Valium (diazepam) are benzodiazepines used in the treatment of anxiety and certain types of seizures. Klonopin is also used to treat panic disorder, while Valium is also used to treat hallucinations resulting from alcohol withdrawal and for sedation during surgery. Learn about the side effects, recommended dosage and main differences between these two drugs.Klonopin (clonazepam) vs. Xanax (alprazolam)
Klonopin (clonazepam) and Xanax (alprazolam) are prescription drugs that belong to the drug class of benzodiazepines. Even though both of these drugs are benzodiazepines they are prescribed slightly differently. Klonopin and Xanax are both prescribed to treat anxiety disorders; however, Klonopin also is prescribed to treat certain types of seizures and Lennox-Gastaut syndrome.Klonopin vs. Ativan
Klonopin (clonazepam) and Ativan (lorazepam) are medications used to treat anxiety and panic attacks. Both drugs are also sometimes used for treating seizures. Both drugs are members of the benzodiazepine class. Learn more about the dosage, side effects, and pregnancy safety information for these anxiety medications.Lyrica (pregabalin) vs. Klonopin (clonazepam)
Lyrica (pregabalin) and Klonopin (clonazepam) are used to treat and prevent seizures. Lyrica is also used to treat neuropathic pain associated with diabetic peripheral neuropathy or postherpetic neuralgia, and fibromyalgia.
Separation Anxiety
Separation anxiety disorder is a common childhood anxiety disorder that has many causes. Infants, children, older kids and adults can suffer from symptoms of separation anxiety disorder. Common separation anxiety treatment methods include therapy and medications. Factors that contribute to how quickly or successfully a child moves past separation anxiety by preschool age include how well the parent and child reunite, the skills the child and adult have at coping with the separation, and how well the adult responds to the infant's separation issues. For example, children of anxious parents tend to be anxious children.What Are the Side Effects of Antiepileptic Drugs?
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