ketorolac tromethamine eye drops

Medically Reviewed on 4/4/2023

Generic Name: ketorolac tromethamine

Brand Names: Acular, Acular LS, Acuvail

Drug Class: Ophthalmic NSAIDs

What are ketorolac tromethamine eye drops, and what are they used for?

Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, indomethacin, naproxen, and many others. Ketorolac blocks prostaglandin synthesis. Prostaglandins have many effects in the body including their role in pain and inflammation. In the eye prostaglandin is involved in inflammation, pain, and irritation due to allergies or mechanical injury. Ketorolac provides relief from pain and inflammation in the eyes. The FDA approved ketorolac eye drops in November 1992.

What are the side effects of ketorolac tromethamine eye drops?

Side effects of Ketorolac are:

  • burning and stinging of eyes,
  • corneal edema,
  • inflammation and irritation,
  • eye infection,
  • dryness,
  • visual disturbances, and
  • headache.

Which drugs interact with ketorolac tromethamine eye drops?

Ketorolac should not be used with other NSAID eye drops due to risks of increased bleeding and delayed healing.

Ketorolac should be used with caution with steroid-containing eye drops due to increased likelihood of infections.

Ketorolac should be used with caution in patients who bleed easily or patients receiving blood thinners.

Pregnancy and breastfeeding

There are no adequate studies done on Ketorolac to determine safe and effective use in pregnant women.

It is not known whether Ketorolac enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

What else should I know about ketorolac tromethamine eye drops?

What preparations of ketorolac tromethamine eye drops are available?

Ophthalmic Solution: 0.4%, 0.45%, 0.5%

How should I keep ketorolac tromethamine eye drops stored?

Store Ketorolac eye drops between temperatures 5 C to 30 C (59 F to 86 F), and protect from light.


Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow


Ketorolac tromethamine is a NSAID medication similar to other NSAIDs like ibuprophen, naproxen, and many others. Ketorolac tromethamine is prescribed for the treatment of allergic conjunctivitis (pink eye), post operative inflammation pain, burning, and stinging after eye surgery such as cataract surgery or corneal refractory surgery. Side effects, drug interactions, dosage, and storage information should be reviewed prior to using this medication.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 4/4/2023
Ketorolac FDA Prescribing Information.