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- What is ketoprofen, and how does it work (mechanism of action)?
- What brand names are available for ketoprofen?
- Is ketoprofen available as a generic drug?
- Do I need a prescription for ketoprofen?
- What are the side effects of ketoprofen?
- What is the dosage for ketoprofen?
- Which drugs or supplements interact with ketoprofen?
- Is ketoprofen safe to take if I'm pregnant or breastfeeding?
- What else should I know about ketoprofen?
What is ketoprofen, and how does it work (mechanism of action)?
Ketoprofen is an oral drug that belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), naproxen (Aleve) and many others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals produced by the body that are responsible for pain, fever, and inflammation. Ketoprofen reduces prostaglandins by blocking the enzyme that makes them (cyclooxygenase). As a consequence, inflammation, pain and fever are reduced.
The FDA approved ketoprofen in January 1986.
What are the side effects of ketoprofen?
The most common side effects from ketoprofen are:
- Ringing in the ears
- Abdominal pain
- Retention of fluid
- Shortness of breath
NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury.
Ketoprofen also may cause stomach and intestinal bleeding from ulcers. Sometimes, stomach ulceration and intestinal bleeding occur without any abdominal pain. Black tarry stools (due to blood in the stool), weakness, and dizziness upon standing (orthostatic hypotension) may be the only signs of the bleeding.
People who are allergic to other NSAIDs should not use ketoprofen. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously.
Individuals with asthma are more likely to experience allergic reactions to ketoprofen and other NSAIDs.
Other medical conditions that also have been associated with the use of NSAIDs include:
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What is the dosage for ketoprofen?
- The usual starting dose of ketoprofen is 50 or 75 mg with immediate release capsules every 6 to 8 hours or 200 mg with extended release capsules once daily.
- The maximum dose is 300 mg daily of immediate release capsules or 200 mg daily of extended release capsules.
- Ketoprofen should be taken with food in order to avoid stomach upset.
- Menstrual cramps are treated with 25-50 mg every 6 to 8 hours using immediate release capsules.
- Rheumatoid or osteoarthritis are treated with 75 mg three times daily or 50 mg four times daily using immediate release capsules or 200 mg daily of extended release capsules.
Which drugs or supplements interact with ketoprofen?
- Ketoprofen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys which may lead to lithium toxicity.
- Ketoprofen may reduce the blood pressure lowering effects of blood pressure medications. This occurs because prostaglandins play a role in reducing blood pressure.
- When NSAIDs are combined with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase because their elimination is reduced. This may lead to more methotrexate or aminoglycoside side effects.
- Individuals taking blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid ketoprofen because ketoprofen also thins the blood, and excessive blood thinning may lead to bleeding.
- Combining NSAIDs such as ketoprofen with angiotensin receptor blockers (ARBs) (for example valsartan [Diovan], losartan [Cozaar], irbesartan [Avapro]) or angiotensin converting enzyme inhibitors (ACE inhibitors), (for example, enalapril [Vasotec], captopril [Capoten] in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible.
- Persons who have more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking ketoprofen or other NSAIDs.
Is ketoprofen safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of ketoprofen in pregnant women. Therefore, ketoprofen is not recommended during pregnancy.
It is not known whether ketoprofen is excreted in breast milk.
What else should I know about ketoprofen?
What preparations of ketoprofen are available?
Capsules (immediate release): 50 and 75 mg; Capsules (extended-release): 100, 150 and 200 mg. Oral Film: 12.5 mg
How should I keep ketoprofen stored?
Ketoprofen should be stored in a sealed container at room temperature, 15 C to 30 C (59 F to 86 F), avoiding moisture and protected from excessive heat.
Ketoprofen (Nexcede, Orudis, Oruvail, Actron brands have been discontinued) is a NSAID prescribed to treat inflammation and pain caused by menstrual cramps, types of arthritis like rheumatoid arthritis and osteoarthritis, and other causes of mild to moderate pain. Side effects, drug interactions, storage, dosing, and breastfeeding and pregnancy safety information should be reviewed prior to taking any medication.
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Medications & Supplements
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- Tramadol: for Pain (Ultram, Ultram ER, Conzip)
- meloxicam (Mobic) Side Effects
- naproxen (Aleve, Anaprox, Naprelan, Naprosyn)
- ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, and others)
- celecoxib (Celebrex)
- Drugs: What You Should Know About Your Drugs
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Foot PainFoot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout), viruses, fungi, and bacteria (plantar warts and athlete's foot), or even ingrown toenails. Pain and tenderness may be accompanied by joint looseness, swelling, weakness, discoloration, and loss of function. Minor foot pain can usually be treated with rest, ice, compression, and elevation and OTC medications such as acetaminophen and ibuprofen. Severe pain should be treated by a medical professional.
Hip BursitisBursitis of the hip results when the fluid-filled sac (bursa) near the hip becomes inflamed due to localized soft tissue trauma or strain. Symptoms include stiffness and pain around the hip joint. If the hip bursa is not infected, hip bursitis can be treated with ice compresses, rest, and anti-inflammatory and pain medications.
Knee Pain FactsAcute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
Low Back PainThere are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
Neck PainNeck pain (cervical pain) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
OsteoarthritisOsteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis. Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
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Shoulder and Neck Pain HealthShoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff injury. Symptoms also include weakness, numbness, coolness, color changes, swelling, and deformity. Treatment at home may incorporate resting, icing, and elevating the injury. A doctor may prescribe pain medications and immobilize the injury.
Shoulder BursitisShoulder bursitis is inflammation of the shoulder bursa. Bursitis may be caused by injury, infection, or a rheumatic condition. Symptoms include pain, swelling, tenderness, and pain with movement of the shoulder joint. Treatment may involve ice compresses, rest, and anti-inflammatory medications and depends on whether there is an infection.