- Ketoconazole cream vs. miconazole: What's the difference?
- What is ketoconazole cream? What is miconazole?
- What are the side effects of ketoconazole and miconazole?
- What is the dosage of ketoconazole vs. miconazole?
- What drugs interact with ketoconazole and miconazole?
- Are ketoconazole and miconazole safe to use while pregnant or breastfeeding?
Ketoconazole cream vs. miconazole: What's the difference?
- Ketoconazole cream and miconazole are antifungal medications prescribed to treat fungal infections such as athlete's foot and ringworm.
- Ketoconazole cream is used to treat jock itch, dandruff, tinea versicolor, blastomycosis, histoplasmosis, and coccidiomycosis.
- Miconazole is also used to treat vaginal fungal infections.
- Brand names for ketoconazole include Nizoral, Nizoral A-D, Ketodan, Extina, Xolegel, and Kuric.
- Brand names for miconazole include Monistat, M-Zole, and Micatin.
- Side effects of ketoconazole and miconazole that are similar include skin rash and itching.
- Side effects of ketoconazole that are different from miconazole include nausea, vomiting, abdominal pain, headache, dizziness, fatigue, impotence, and blood count abnormalities.
- Side effects of miconazole that are different from ketoconazole include skin irritation and burning.
What is ketoconazole cream? What is miconazole?
Ketoconazole cream is an antifungal medication in the same family of drugs as fluconazole (Diflucan), itraconazole (Sporanox), and miconazole (Micatin, Monistat). It prevents growth of several types of fungi by preventing production of the membranes that surround fungal cells. Ketoconazole cream is prescribed to treat fungal infections such as ringworm, jock itch, athlete's foot, dandruff, and tinea versicolor.
Miconazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the to treat vaginal infections and other infections (athlete's foot, ringworm), and severe fungal infections.
What are the side effects of ketoconazole and miconazole?
Ketoconazole generally is well tolerated. Commonly reported side effects of ketoconazole are:
- abdominal pain,
- impotence, and
- blood count abnormalities.
Other important side effects of ketoconazole are rare; they include:
Liver dysfunction also has been reported. Signs of liver problems include unusual fatigue, loss of appetite, nausea and vomiting, yellowing of the skin (jaundice), dark urine, and pale stools. Development of these symptoms while taking ketoconazole should be reported to a physician.
Irritation, burning, rash and itching have been reported by patients using topical or vaginal miconazole.
Latest Sexual Health News
Daily Health News
What is the dosage of ketoconazole vs. miconazole?
Ketoconazole may be taken with or without food. The oral dose range is 200-400 mg daily. Recurrent tinea versicolor is treated with 400 mg monthly. Topical formulations are administered to affected areas once or twice daily.
Miconazole vaginal cream and suppositories are for use only in the vagina. These products are not to be taken by mouth. The vaginal suppositories are inserted, one per dose, in an applicator. Alternatively, the tube containing the vaginal cream is screwed onto the end of a special applicator tube, and the tube is then squeezed to fill the applicator. The patient then lies on her back with bent knees, inserts the applicator containing either the suppository or cream so that the tip of the applicator is high in the vagina, and then pushes the plunger in to deposit the suppository or cream into the vagina. The applicator should be washed with warm soap and water after each use.
Miconazole usually is used once daily at bedtime. The 200 mg suppositories (Monistat 3) are inserted once nightly for 3 nights. The 100 mg suppositories (Monistat-7) and intravaginal cream are inserted once nightly for 7 nights. The 1200 mg formulation (Monistat 1) is applied once for one night.
For fungal skin infections, the topical cream is applied as a thin layer to cover the affected skin and surrounding area, usually once or twice daily for 2-4 weeks. The hands should be washed before and after application.
What drugs interact with ketoconazole and miconazole?
Avoid using other skin or hair products that can cause irritation, such as harsh soaps or shampoos or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.
Avoid getting this medication in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water.
Avoid covering treated skin areas with tight-fitting, synthetic clothing (such as nylon or polyester) that doesn't allow air to circulate to your skin. If you are treating your feet, wear clean cotton socks and sandals or shoes that allow for air circulation. Keep your feet as dry as possible.
There are no known drug interactions with vaginal or topical miconazole.
Subscribe to MedicineNet's General Health Newsletter
Are ketoconazole and miconazole safe to use while pregnant or breastfeeding?
There is very limited information on the use of miconazole during pregnancy. The physician must weigh the potential benefits against possible but unknown risks to the fetus.
It is not known if miconazole is secreted in breast milk in amounts that can affect the infant.
Ketoconazole (Nizoral) cream and miconazole (Monistat) are antifungal medications prescribed to treat fungal infections such as athlete's foot and ringworm. Ketoconazole cream is used to treat jock itch, dandruff, tinea versicolor, blastomycosis, histoplasmosis, and coccidiomycosis. Miconazole is also used to treat vaginal fungal infections.
Multimedia: Slideshows, Images & Quizzes
Yeast Infection Quiz: Symptoms & Treatment
How much do you know about vaginal yeast infections? Learn the causes, symptoms, and treatments of a yeast infection with the...
Picture of Yeast Infections (Thrush in Babies)
Thrush is a yeast infection that causes white patches in the mouth and on the tongue. See a picture of Yeast Infection (Thrush)...
Picture of Baby Yeast Infections
Thrush is a yeast infection that causes white patches in the mouth and on the tongue. See a picture of Baby Yeast Infections and...
Related Disease Conditions
The term "ringworm" or "ringworms" refers to fungal infections that are on the surface of the skin. A physical examination of the affected skin, evaluation of skin scrapings under the microscope, and culture tests can help doctors make the appropriate distinctions. A proper diagnosis is essential to successful treatment. Among the different types of ringworm are the following: tinea barbae, tinea capitis, tinea corporis, tinea cruris, tinea faciei, tinea manus, tinea pedis, and tinea unguium.
Vaginal Yeast Infection (in Women and Men)
Vaginal yeast infections in women are caused by an organism called Candida albicans. Symptoms of a vaginal yeast infection include vaginal pain with urination, vaginal discharge, odor, and itching. Treatment is generally OTC medications. A man can contract a yeast infection from his female sexual partner. Symptoms of a yeast infection in men include penile itching. Treatment is with oral or topical medication.
Yeast infections vs. STDs in Men and Women
Is Ringworm Contagious?
A fungus causes ringworm. Ringworm can be transmitted from person to person. Animals may also spread ringworm. Ringworm causes an itchy, ring-shaped red rash with hair loss. Treatment incorporates the use of topical medication.
Is a Yeast Infection Contagious?
Yeast are a fungi that has many types. A type of yeast that can cause infection in humans is called Candida. Candida can infect the mouth, vagina, penis, or other areas of the body. Symptoms of yeast infections depend on the area infected, however, may include itching, bumps on the skin, a reddish rash, or patches of skin that ooze a clear or yellow liquid. Most yeast infections are not contagious even though they are caused by a fungus.
Thrush and Other Yeast Infections in Children
Yeast infections are caused by an overgrowth of a type of fungus called Candida. Oral thrush is a yeast infection of the mouth and throat. Oral thrush and yeast infections are treated orally or topically with an antifungal antibiotic called nystatin.
Dandruff (seborrhea) is a skin disorder that results from neither too much moisture nor too much oil. Dandruff can be treated with shampoos that contain tar, salicylic acid, zinc, selenium sulfide, or ketoconazole.
Treatment & Diagnosis
Medications & Supplements
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.