- Ketoconazole cream vs. Lamisil: What's the difference?
- What is ketoconazole cream? What is Lamisil?
- What are the side effects of ketoconazole and Lamisil?
- What is the dosage for ketoconazole vs. Lamisil?
- What drugs interact with ketoconazole and Lamisil?
- Are ketoconazole and Lamisil safe to use while pregnant or breastfeeding?
Ketoconazole cream vs. Lamisil: What's the difference?
- Ketoconazole cream and Lamisil (terbinafine) are antifungal medications used to treat fungal infections such as jock itch and athlete's foot.
- Ketoconazole cream is also used to treat ringworm, dandruff, and tinea versicolor.
- Brand names for ketoconazole include Nizoral, Nizoral A-D, Ketodan, Extina, Xolegel, and Kuric.
- Lamisil is available as a generic and over-the-counter (OTC). Oral forms of terbinafine require a prescription.
- Side effects of ketoconazole and Lamisil that are similar include headache, abdominal pain, and itching.
- Side effects of ketoconazole that are different from Lamisil include rash, nausea, vomiting, dizziness, fatigue, impotence, and blood count abnormalities.
- Side effects of Lamisil that are different from ketoconazole include cough, diarrhea, hives, and altered taste and smell sensation.
What is ketoconazole cream? What is Lamisil?
Ketoconazole cream is an antifungal medication in the same family of drugs as fluconazole (Diflucan), itraconazole (Sporanox), and miconazole (Micatin, Monistat). Ketoconazole cream works by inhibiting the growth of a number of types of fungi by preventing production of the membranes that surround fungal cells. Ketoconazole cream is used to treat fungal infections including ringworm, jock itch, athlete's foot, dandruff, and tinea versicolor.
Lamisil (terbinafine) is an antifungal medication taken by mouth or applied to the skin used to treat fungal nails, jock itch, and athlete's foot. Lamisil acts by interfering with the ability of fungi to make chemicals called sterols that are an important part of the membrane that surrounds fungal cells and holds them together. This weakens the cell membrane. Oral terbinafine is more effective for treating fungal nail infections than griseofulvin (Fulvicin; Gris-Peg) and itraconazole (Sporanox), two other antifungal agents used for treating fungal nail infections.
What are the side effects of ketoconazole and Lamisil?
Ketoconazole generally is well tolerated. Commonly reported side effects of ketoconazole are:
- abdominal pain,
- impotence, and
- blood count abnormalities.
Other important side effects of ketoconazole are rare; they include:
Liver dysfunction also has been reported. Signs of liver problems include unusual fatigue, loss of appetite, nausea and vomiting, yellowing of the skin (jaundice), dark urine, and pale stools. Development of these symptoms while taking ketoconazole should be reported to a physician.
The most common side effects of terbinafine are:
Oral terbinafine can cause liver failure sometimes leading to liver transplantation or death.
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What is the dosage for ketoconazole vs. Lamisil?
Ketoconazole may be taken with or without food. The oral dose range is 200-400 mg daily. Recurrent tinea versicolor is treated with 400 mg monthly. Topical formulations are administered to affected areas once or twice daily.
Tablets: The usual dose is 250 mg once daily for 6 weeks for treatment of the fingernails, and 12 weeks for treatment of toenails. Optimal results will not be seen for several months after treatment because it takes time for new healthy nails to grow. Terbinafine may be taken with or without food.
Cream, gel, spray, solution: Apply to affected area (s) once (jock itch, ringworm) or twice daily (athletes foot) for about for 1 week.
What drugs interact with ketoconazole and Lamisil?
Avoid using other skin or hair products that can cause irritation, such as harsh soaps or shampoos or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.
Avoid getting this medication in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water.
Avoid covering treated skin areas with tight-fitting, synthetic clothing (such as nylon or polyester) that doesn't allow air to circulate to your skin. If you are treating your feet, wear clean cotton socks and sandals or shoes that allow for air circulation. Keep your feet as dry as possible.
Rifampin reduces oral terbinafine blood concentrations, potentially reducing the efficacy of terbinafine. Cimetidine (Tagamet) may increase oral terbinafine blood levels, potentially increasing side effects of terbinafine. Fluconazole (Diflucan) increases the blood levels of oral terbinafine by 52%-69%. Potentially leading to increased side effects.
Are ketoconazole and Lamisil safe to use while pregnant or breastfeeding?
Breastfeeding mothers should not use oral terbinafine because terbinafine passes into breast milk.
Skin Problems and Treatments Resources
Ketoconazole cream and Lamisil (terbinafine) are antifungal medications used to treat fungal infections such as jock itch and athlete's foot. Ketoconazole cream is also used to treat ringworm, dandruff, and tinea versicolor.
Multimedia: Slideshows, Images & Quizzes
Picture of Ringworm Tinea Corporis (Faciei)
Ringworm infection on a 51-year-old woman's skin. Ringworm (tinea) is a disease caused by a fungal infection of the skin. It can...
Picture of Ringworm Tinea Pedis
Close-up of athlete's foot (tinea pedis) on the foot of a 66year old man. See a picture of Ringworm Tinea Pedis and learn more...
Picture of Ringworm Tinea Unguium (Onychomycosis)
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Skin Quiz: Acne, Dry Skin, Dandruff & More
What's that all over you? Skin, of course! Test your knowledge of your most amazing organ with the Skin Quiz!
Ringworm Quiz: Test your Medical IQ
Ringworm: Treatment, Pictures, Causes, and Symptoms
What is ringworm? How do you get rid of ringworm? View ringworm pictures on the scalp and body and learn about ringworm...
Picture of Ringworm of the Nails
This is the most common fungal infection of the nails, also called onychomycosis. See a picture of Ringworm of the Nails and...
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A mild skin condition that produces white flakes that may be shed and fall from the hair. See a picture of Dandruff and learn...
Picture of Pet Ringworm
Ringworm is an example of a zoonotic disease (transmitted from animals to humans). See a picture of Pet Ringworm and learn more...
Picture of Ringworm of the Hand
Ringworm may involve the hands, particularly the palms and the spaces between the fingers. See a picture of Ringworm of the Hand...
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Athlete's foot is a fungus that causes itching, redness, and cracking. See a picture of Athlete's Foot and learn more about the...
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Ringworm is a fungal infection of the skin previously thought to be due to a parasite (worm). See a picture of Ringworm and learn...
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This superficial skin infection, also known as tinea, is caused by fungi called dermatophytes. See a picture of Ringworm and...
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Related Disease Conditions
Jock itch is an itchy red rash that appears in the groin area. The rash may be caused by a bacterial or fungal infection. People with diabetes and those who are obese are more susceptible to developing jock itch. Antifungal shampoos, creams, and pills may be needed to treat fungal jock itch. Bacterial jock itch may be treated with antibacterial soaps and topical and oral antibiotics.
The term "ringworm" refers to a fungal infection on the surface of the skin. A physical examination of the affected skin, evaluation of skin scrapings under the microscope, and culture tests can help doctors make the appropriate distinctions. A proper diagnosis is essential to successful treatment. The different types of ringworm include the following: tinea barbae, tinea capitis, tinea corporis, tinea cruris, tinea faciei, tinea manus, tinea pedis, and tinea unguium.
Is Ringworm Contagious?
A fungus causes ringworm. Ringworm can be transmitted from person to person. Animals may also spread ringworm. Ringworm causes an itchy, ring-shaped red rash with hair loss. Treatment incorporates the use of topical medication.
Athlete's foot (tinea pedis) is a skin infection caused by the ringworm fungus. Symptoms include itching, burning, cracking, peeling, and bleeding feet. Treatment involves keeping the feet dry and clean, wearing shoes that can breathe, and using medicated powders to keep your feet dry.
Dandruff (seborrhea) is a skin disorder that results from neither too much moisture nor too much oil. Dandruff can be treated with shampoos that contain tar, salicylic acid, zinc, selenium sulfide, or ketoconazole.
Is Dandruff (Seborrhea) Contagious?
Seborrheic dermatitis (dandruff) is a chronic condition in which skin on the scalp flakes and sheds. Dandruff is not contagious. Sunlight exposure and stress reduction can improve the symptoms and signs of dandruff.
Is Jock Itch (Tinea Cruris) Contagious?
Jock itch is a fungal infection in the groin area that causes a raised, itchy, red rash. Jock itch can typically be treated with antifungal medications. People may need to seek medical care for jock itch if the groin area becomes swollen, tender, if red streaks appear, or if the lymph nodes become swollen.
Dandruff vs. Dry Scalp
Dandruff is a condition characterized by small white flakes that shed from the scalp. Dry scalp is simply dry skin on one's head. Dry scalp is uncommon, and dandruff is very common. Dandruff treatment and prevention incorporates the regular use of an anti-dandruff shampoo.
Treatment & Diagnosis
Medications & Supplements
- ketoconazole shampoo - topical, Nizoral
- ketoconazole cream - topical, Nizoral
- ketoconazole - oral, Nizoral
- terbinafine solution - topical, Lamisil
- terbinafine cream - topical, Lamisil
- terbinafine - oral, Lamisil
- Ketoconazole cream vs. clotrimazole cream
- Lamisil (terbinafine) vs. Lotrimin (clotrimazole)
- Ketoconazole Cream (Nizoral) vs. Miconazole (Monistat)
- ketoconazole, Nizoral, Extina, Xolegel, Kuric
- terbinafine (Lamisil)
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IMAGESBrowse our medical image collection of allergic skin disorders such as psoriasis and dermatitis and more caused by allergies See Images
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