ketoconazole, Nizoral, Extina, Xolegel, Kuric

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is ketoconazole, and how does it work (mechanism of action)?

Ketoconazole is an anti-fungal medication in the same family of drugs as fluconazole (Diflucan), itraconazole (Sporanox), and miconazole (Micatin, Monistat). It prevents growth of several types of fungi by preventing production of the membranes that surround fungal cells. The FDA approved ketoconazole in June 1981.

What brand names are available for ketoconazole?

Nizoral, Nizoral A-D, Ketodan, Extina, Xolegel, Kuric

Is ketoconazole available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for ketoconazole?

: Yes

What are the side effects of ketoconazole?

Ketoconazole generally is well tolerated. Commonly reported side effects of ketoconazole are:

Other important side effects of ketoconazole are rare; they include:

Liver dysfunction also has been reported. Signs of liver problems include unusual fatigue, loss of appetite, nausea and vomiting, yellowing of the skin (jaundice), dark urine, and pale stools. Development of these symptoms while taking ketoconazole should be reported to a physician.

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What is the dosage for ketoconazole?

Ketoconazole may be taken with or without food. The oral dose range is 200-400 mg daily. Recurrent tinea versicolor is treated with 400 mg monthly. Topical formulations are administered to affected areas once or twice daily.

Is ketoconazole safe to take if I'm pregnant or breastfeeding?

A small amount of ketoconazole is secreted in breast milk. Nursing mothers should probably avoid breastfeeding while using ketoconazole.

What else should I know about ketoconazole?

What preparations of ketoconazole are available?

Tablets: 200 mg; Shampoo: 1% and 2%; Cream: 2%, Gel: 2%, Foam: 2%

How should I keep ketoconazole stored?

  • Store tablets at room temperature, 15 C to 25 C (59 F to 77 F) and protected from moisture.
  • Store shampoo 1% between 2 C to 30 C (35 F to 86 F) and protected from light and freezing.
  • Store shampoo 2% at or below 25 C (77 F) and protected from light.
  • Store cream and foam at room temperature, 20 C to 25 C (68 F to 77 F).
  • Store gel between 15C to 30 C (59 F to 86 F).

Reference: FDA Prescribing Information

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Summary

Ketoconazole (Nizoral, Extina, Xolegel, Kuric) is an anti-fungal medication prescribed to treat fungal infections such as thrush, ringworm, jock itch, athlete's foot, dandruff, tinea versicolor, blastomycosis, histoplasmosis, and coccidiomycosis. Side effects and drug interactions should be reviewed prior to taking this medication.

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See more info: ketoconazole on RxList
Reviewed on 12/30/2014
References
Reference: FDA Prescribing Information

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