Jardiance (empagliflozin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Do I need a prescription for Jardiance (empagliflozin)?

  • Yes

What are the uses for Jardiance (empagliflozin)?

What are the side effects of Jardiance (empagliflozin)?

The most common side effects of Jardiance are:

Other possible side effects of Jardiance include:

Volume depletion and associated conditions, which include:

Serious side effects of Jardiance include:

What is the dosage for Jardiance (empagliflozin)?

  • The recommended dose of Jardiance is 10 mg once daily. It should be taken in the morning with or without food. The dose may be increased to 25 mg daily based on patient tolerance and blood glucose levels.
  • Patients with volume depletion should be treated for their depletion before receiving Jardiance.
  • Jardiance should not be used by patients whose glomerular filtration rate (a measure of kidney function) is 45 mL/min/1.73 m2

Quick GuideDiabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating

Diabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating

Which drugs or supplements interact with Jardiance (empagliflozin)?

  • Combining Jardiance with diuretics increases the frequency of urination and volume of urine produced. This may increase the risk of dehydration.
  • Combining Jardiance with insulin or drugs that increase insulin secretion increases the risk for hypoglycemia.
  • Jardiance and other SGLT2 inhibitors increase excretion of glucose in urine and will cause positive urine glucose tests. Therefore, monitoring glucose control with urine glucose tests is not recommended in patients taking SGLT2 inhibitors. Alternative tests should be used to monitor glucose control.

Is Jardiance (empagliflozin) safe to use during pregnancy or while breastfeeding?

  • Use of Jardiance has not been adequately evaluated in pregnant women. In animal studies, Jardiance affected renal (kidney) development and maturation in rats. Jardiance is not recommended during the second and third trimesters of pregnancy.
  • It is not known whether Jardiance is excreted in human breast milk. However, Jardiance is secreted in the milk of lactating rats, and exposure damages the developing kidneys in the rat fetus. Currently, the manufacturer does not recommend use of Jardiance while nursing.

What else should I know about Jardiance (empagliflozin)?

What preparations of Jardiance (empagliflozin) are available?
  • Tablets: 10, 25 mg
How should I keep Jardiance (empagliflozin) stored?
  • Store empagliflozin at room temperature, between 15 C and 30 C (59 F and 86 F).
How does Jardiance (empagliflozin) work?
  • SGLT2 is found in the kidney tubules and is responsible for reabsorbing the majority of glucose filtered out of the blood by the kidneys. By inhibiting SGLT2 empagliflozin reduces the reabsorption of filtered glucose and consequently increases excretion of glucose in the urine. Empagliflozin is not recommended for use in patients with moderate to severe kidney disease.
When was Jardiance (empagliflozin) approved by the FDA?
  • Empagliflozin was approved by the US FDA in August 2014.

REFERENCE: FDA Prescribing Information

Quick GuideDiabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating

Diabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating


Jardiance (empagliflozin) is a prescription drug used to manage blood glucose in people with type 2 diabetes. Jardiance belongs to a drug class called SGLT2 (sodium-glucose cotransporter) inhibitors. Common side effects include:

Drug interactions, dosage, and pregnancy and breastfeeding safety information are provided.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Reviewed on 12/13/2016
REFERENCE: FDA Prescribing Information

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