- Related Diseases
- Images & Quizzes
- A Visual Guide to Heart Disease
- Medical Illustrations of the Heart Image Collection
- Take the Heart Disease Quiz!
- What is isosorbide dinitrate, and how does it work (mechanism of action)?
- What brand names are available for isosorbide dinitrate?
- Is isosorbide dinitrate available as a generic drug?
- Do I need a prescription for isosorbide dinitrate?
- What are the side effects of isosorbide dinitrate?
- What is the dosage for isosorbide dinitrate?
- Which drugs or supplements interact with isosorbide dinitrate?
- Is isosorbide dinitrate safe to take if I'm pregnant or breastfeeding?
- What else should I know about isosorbide dinitrate?
What is isosorbide dinitrate, and how does it work (mechanism of action)?
Isosorbide dinitrate is in the class of drugs called nitrates, and it is used for treating and preventing angina or heart pain. Other nitrates include nitroglycerin (Nitrostat, Nitroquick, Nitrolingual, Nitro-Dur and others) and isosorbide mononitrate (Imdur, Ismo, Monoket). Isosorbide dinitrate is converted in the body to isosorbide mononitrate which is the active chemical.
Nitrates are vasodilators (dilators of blood vessels). Blood returning from the body in the veins must be pumped by the heart through the lungs and into the body's arteries against the high pressure in the arteries. In order to accomplish this work, the heart's muscle must produce and use energy ("fuel"), and this requires oxygen. Angina pectoris (angina) or "heart pain" is due to an inadequate flow of blood (and oxygen) to the muscle of the heart. Nitrates, including isosorbide dinitrate, improve the flow of blood and oxygen to the heart and reduce the work that the heart must do by dilating (expanding) the arteries and veins in the body. Dilation of the veins reduces the amount of blood that returns to the heart that must be pumped. Dilation of the arteries lowers the pressure in the arteries against which the heart must pump. As a consequence of both effects, the heart works less and requires less blood and oxygen. In addition, nitrates dilate the arteries that supply the heart with blood so that the heart receives more blood and oxygen. The FDA approved isosorbide dinitrate in January 1968.
What are the side effects of isosorbide dinitrate?
Headaches are the most common side effect of isosorbide dinitrate and usually are dose-related (increase with higher doses). Flushing may occur because isosorbide dinitrate dilates blood vessels. Isosorbide dinitrate may cause a drop in blood pressure when rising from a sitting position (orthostatic hypotension), causing dizziness, palpitations, and weakness. To reduce the risk of these side effects, patients should rise slowly from a sitting position.
Quick GuideHeart Disease: Symptoms, Signs, and Causes
What is the dosage for isosorbide dinitrate?
Isosorbide dinitrate tablets can be taken with or without food. The sublingual tablets should be dissolved under the tongue and should not be crushed or chewed. Tolerance (reduced effect after several doses) may develop, so a drug free period of at least 14 hours is recommended. The recommended doses of isosorbide dinitrate are:
Which drugs or supplements interact with isosorbide dinitrate?
Sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra) increase the blood pressure lowering effects of isosorbide dinitrate and may cause excessive blood pressure reduction. Patients taking isosorbide dinitrate should not take sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra). Severe blood pressure reduction, especially when changing posture, may occur when isosorbide dinitrate is combined with calcium channel blockers, for example, diltiazem (Cardizem, Tiazac, etc.) and verapamil (Calan, Verelan, etc.) which also reduce blood pressure.
Is isosorbide dinitrate safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of isosorbide dinitrate in pregnant women.
It is not known if isosorbide dinitrate is excreted in human breast-milk.
What else should I know about isosorbide dinitrate?
What preparations of isosorbide dinitrate are available?
Tablets (sublingual): 2.5 and 5 mg. Tablets (immediate release): 5, 10, 20, 30, and 40 mg. Tablets (extended release): 40 mg. Capsules (sustained release): 40 mg
How should I keep isosorbide dinitrate stored?
Isosorbide dinitrate should be stored at room temperature, 15 C - 30 C (59 F - 86 F).
Reference: FDA Prescribing Information
Quick GuideHeart Disease: Symptoms, Signs, and Causes
Daily Health News
Healthy Heart Resources
Subscribe to MedicineNet's Heart Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
- isosorbide dinitrate (Isordil Titradose, Dilatrate-SR, Isochron) Related Diseases
- isosorbide dinitrate (Isordil Titradose, Dilatrate-SR, Isochron) Images & Quizzes
- isosorbide dinitrate (Isordil Titradose, Dilatrate-SR, Isochron) Index
Top isosorbide dinitrate Related ArticlesComplete List
Heart-Healthy FoodsSee 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and menu ideas for heart health.
AchalasiaEsophageal achalasia is a disease of the esophagus that mainly affects young adults. Achalasia makes it difficult to swallow, can cause chest pain, and may lead to regurgitation. Here we discuss achalasia symptoms, surgery, treatment, and causes. Learn the definition of achalasia and what you can do to treat the disease.
Angina SymptomsAngina is chest pain due to inadequate blood supply to the heart. Angina symptoms may include chest tightness, burning, squeezing, and aching. Coronary artery disease is the main cause of angina but there are other causes. Angina is diagnosed by taking the patient's medical history and performing tests such as an electrocardiogram (EKG), blood test, stress test, echocardiogram, cardiac CT scan, and heart catheterization. Treatment of angina usually includes lifestyle modification, medication, and sometimes, surgery. The risk of angina can be reduced by following a heart healthy lifestyle.
Chest PainChest pain is a common complaint by a patient in the ER. Causes of chest pain include broken or bruised ribs, pleurisy, pneumothorax, shingles, pneumonia, pulmonary embolism, angina, heart attack, costochondritis, pericarditis, aorta or aortic dissection, and reflux esophagitis. Diagnosis and treatment of chest pain depends upon the cause and clinical presentation of the patient's chest pain.
Congestive Heart Failure (CHF) OverviewCongestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Heart Detail PictureThe heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an anatomically separate left atrium and ventricle. See a picture of Heart Detail and learn more about the health topic.
Heart Disease (Coronary Artery Disease)
Heart disease (coronary artery disease) occurs when plaque builds up in the coronary arteries, the vessels that supply blood to the heart. Heart disease can lead to heart attack. Risk factors for heart disease include:
- High blood pressure
- High cholesterol
- Family history
Angina, shortness of breath, and sweating are just a few symptoms that may indicate a heart attack. Treatment of heart disease involves control of heart disease risk factors through lifestyle changes, medications, and/or stenting or bypass surgery. Heart disease can be prevented by controlling heart disease risk factors.
CAD SlideshowWhat is heart disease (coronary artery disease)? Learn about the causes of heart disease. Symptoms of heart disease include chest pain and shortness of breath. Explore heart disease diagnosis, treatment, and prevention.
Heart Disease QuizTake our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes, symptoms, treatments, testing, and procedures for medically broken hearts.
Heart failure (congestive) is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and conditions that overwork the heart. Symptoms of heart failure include
- congested lungs,
- fluid and water retention,
- fatigue and weakness, and
- rapid or irregular heartbeats.
There are two types of congestive heart failure, systolic or left-sided heart failure; and diastolic or right-sided heart failure. Treatment, prognosis, and life-expectancy for a person with congestive heart failure depends upon the stage of the disease.
Heartburn Foods SlidesLearn the symptoms of heartburn and which foods cause heartburn or GERD. Discover home remedies and which foods may provide treatment for heartburn relief.
isosorbide mononitrateIsosorbide mononitrate (Imdur, Ismo, Monoket) is in a class of drugs called nitrates. Isosorbide mononitrate (Imdur, Ismo, Monoket) is used to treat angina pectoris (heart pain, chest pain). Side effects, drug interactions, warnings and precautions, and safety during pregnancy should be reviewed prior to taking this medication.
Lower Cholesterol TipsNeed to lower your cholesterol levels? Use these smart diet tips to quickly and easily lower your blood cholesterol levels. Choose heart-healthy foods to lower cholesterol and improve your heart health.
nizatidineNizatidine (Axid, Axid AR) is a drug prescribed for the treatment and prevention of duodenal and gastric ulcers (peptic, stomach), GERD, and heartburn. Side effects, drug interactions, warnings and precautions, and patient information should be reviewed prior to taking any medication.