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- What is irbesartan, and how does it work (mechanism of action)?
- What brand names are available for irbesartan?
- Is irbesartan available as a generic drug?
- Do I need a prescription for irbesartan?
- What are the side effects of irbesartan?
- What is the dosage for irbesartan?
- Which drugs or supplements interact with irbesartan?
- Is irbesartan safe to take if I'm pregnant or breastfeeding?
- What else should I know about irbesartan?
What is irbesartan, and how does it work (mechanism of action)?
Irbesartan is an oral medication that is used to treat high blood pressure (hypertension) and diabetic nephropathy or kidney disease. It belongs to a class of drugs called angiotensin receptor blockers (ARBs) which also includes valsartan (Diovan), losartan (Cozaar), and candesartan (Atacand). Angiotensin, formed in the blood by the action of angiotensin converting enzyme (ACE), is a powerful chemical that attaches to angiotensin receptors found in many tissues but primarily on smooth muscle cells of blood vessels. Angiotensin's attachment to the receptors causes the blood vessels to narrow (vasoconstrict), which leads to an increase in blood pressure (hypertension ). Irbesartan blocks the angiotensin receptor. By blocking the action of angiotensin, irbesartan dilates blood vessels and reduces blood pressure. The FDA approved irbesartan in September 1997.
What are the side effects of irbesartan?
The most common side effects of irbesartan are:
- abdominal pain or
- fatigue, and
- reduced blood pressure when rising from a sitting or standing position (orthostatic hypotension).
Other important side effects patients may experience include:
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What is the dosage for irbesartan?
Which drugs or supplements interact with irbesartan?
Combining irbesartan with potassium-sparing diuretics (for example., spironolactone [Aldactone], triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to hyperkalemia (elevated potassium in the blood) and toxicity from potassium.
Combining irbesartan or other ARBs with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, fluid-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. There have been reports that aspirin and other NSAIDs such as ibuprofen (Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ARBs.
Is irbesartan safe to take if I'm pregnant or breastfeeding?
All ARBs should not be used during pregnancy. When used in the second or third trimester of pregnancy, irbesartan and similar drugs may cause injury and even death to the fetus. Irbesartan should not be used during pregnancy. When pregnancy is detected, irbesartan should be stopped as soon as possible.
It is not known whether irbesartan is secreted into human milk. Irbesartan is secreted into the milk of rats.
What else should I know about irbesartan?
What preparations of irbesartan are available?
Tablets: 75 mg, 150 mg and 300 mg.
How should I keep irbesartan stored?
Tablets should be stored at room temperature, 15 C -30 C (59 F - 86 F).
Reference: FDA Prescribing Information
Irbesartan (Avapro) is a drug prescribed to treat high blood pressure and diabetic nephropathy (kidney disease). Side effects, drug interactions, dosage, and pregnancy safety should be reviewed prior to taking any medication.
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Angiotensin II Receptor BlockersAngiotensin II receptor blockers (ARBs) are a class of drugs prescribed to control blood pressure, treat heart failure, and prevent kidney failure in people with diabetes or high blood pressure. Examples of ARBs include candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), telmisartan (Micardis), valsartan (Diovan), losartan (Cozaar), and olmesartan (Benicar). Side effects, drug interactions, and patient safety information should be reviewed prior to taking any medication.
candesartanCandesartan cilexetil (Atacand) is a medication prescribed to treat high blood pressure. It is also used for reducing the chance of death or hospitalization due to heart failure. Side effects, drug interactions, warnings and precautions, and pregnancy safety should be reviewed prior to taking this medication.
Diabetes and Kidney DiseaseIn the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. albumin and eGFR are two key markers for kidney disease in people with diabetes. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease. For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Febrile SeizuresFebrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include:
- losing consciousness,
- moving limbs on both sides of the body,
- lasts 1-2 minutes.
High Blood Pressure Hypertension
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms.
Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure.
The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater.
If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.
REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
High Blood Pressure Medication
High blood pressure (hypertension) medications include drugs from a variety of different drug classes and types.
- ACE inhibitors
- ARB (angiotensin receptor blockers)
- Beta blockers
- Calcium channel blockers (CCBs)
- Alpha-beta blockers
Clonidine (Catapres) and minoxidil also are drugs prescribed for the treatment of high blood pressure. Side effects, warnings and precautions, safety information, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
High Blood Pressure TreatmentHigh blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Hypertension PictureHigh blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90. See a picture of Hypertension and learn more about the health topic.
Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss, dehydration, or medication. Some of the renal causes of kidney failure include sepsis, medications, rhabdomyolysis, multiple myeloma, and acute glomerulonephritis.
Post renal causes of kidney failure include bladder obstruction, prostate problems, tumors, or kidney stones.Treatment options included diet, medications, or dialysis.
losartanLosartan (Cozaar) is a medication prescribed fro the treatment of high blood pressure. Losartan (Cozaar) belongs to a class of drugs referred to as ARBs (angiotensin receptor blockers). Side effects, drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
losartan and hydrochlorothiazideLosartan and hydrochlorothiazide (Hyzaar) is a combination drug ( losartan [Cozaar] and hydrochlorothiazide prescribed for the treatment of high blood pressure. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking any medication.
ParathyroidectomyParathyroidectomy is the removal of one or more of the parathyroid glands to treat hyperparathyroidism. Risks of parathyroidectomy include:
- paralysis of the vocal cords,
- difficulty swallowing thin liquids,
- difficulty breathing,
- and drug reactions.
- damage to the recurrent laryngeal nerve,
- bleeding or hematoma,
- problems maintaining calcium levels in the blood,
- need for further and more aggressive surgery,
- need for a limited or total thyroidectomy,
- prolonged pain,
- impaired healing,
- and recurrence of the tumor.
telmisartanTelmisartan (Micardis) is in the drug class of angiotensin receptor blockers (ARBs) and is prescribed for the treatment of high blood pressure, reducing the risk of heart attack, stroke, or death from cardiovascular causes (in patients aged 55 years and older). Side effects, dosing information, drug interactions, and warnings and precautions should be reviewed prior to taking any medication.
valsartanValsartan (Diovan) is an ARB drug prescribed for the treatment of high blood pressure and congestive heart failure. Side effects, drug interactions, warnings and precautions, and pregnancy efficacy should be reviewed prior to taking this medication.