- What is insulin glargine, and how does it work (mechanism of action)?
- What are the side effects of insulin glargine?
- What is the dosage for insulin glargine?
- Which drugs or supplements interact with insulin glargine?
- Is insulin glargine safe to take if I'm pregnant or breastfeeding?
- What else should I know about insulin glargine?
What is insulin glargine, and how does it work (mechanism of action)?
Insulin glargine is a bioengineered (man-made) injectable form of long-acting insulin that is used to regulate sugar (glucose) levels in type 1 and type 2 diabetes. Individuals with type 1 diabetes do not produce insulin on their own; and individuals with type 2 diabetes do not produce enough insulin, or insulin is not as effective due to insulin resistance.
Insulin glargine works the same way as natural human insulin, but it's action lasts longer. It helps diabetic patients regulate glucose or sugar in the body. Insulin glargine works by promoting movement of sugar from blood into body tissues and also stops sugar production in liver. Insulin glargine is man-made insulin that mimics the actions of human insulin.
The FDA approved insulin glargine in April 2000.
What brand names are available for insulin glargine?
Is insulin glargine available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for insulin glargine?
What are the side effects of insulin glargine?
Common side effects of insulin glargine are:
Local allergic reactions that may occur at the injection sites are:
Long term use of insulin glargine can lead to thickening of fat tissues at the injection site.
Severe allergic reactions are:
- Swelling under the skin
- Very low blood pressure
- Bronchospasm (tightening of chest that leads to difficulty breathing)
Individuals should contact a healthcare professional if they experience any of the above reactions.
What is the dosage for insulin glargine?
- The starting dose should be individualized based on the type of diabetes and whether the patient is insulin-naïve.
- Administer subcutaneously once daily at any time of day, but at the same time every day.
- Rotate injection sites within an injection area (abdomen, thigh, or deltoid) to reduce the risk of lipodystrophy.
- Converting from other insulin therapies may require adjustment of timing and dose of Lantus. Closely monitor glucoses especially upon converting to Lantus and during the initial weeks thereafter.
Which drugs or supplements interact with insulin glargine?
There are many drugs that do not directly interfere with insulin glargine, but they may affect glucose breakdown in the body. This necessitates adjustments of insulin glargine doses.
Other drugs that can decrease the blood-sugar-lowering effect of insulin glargine are:
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Is insulin glargine safe to take if I'm pregnant or breastfeeding?
Safe and effective use of insulin glargine is not established for pregnant females.
What else should I know about insulin glargine?
What preparations of insulin glargine are available?
Insulin glargine is available as 100 units/ml. Insulin glargine is supplied in 10 ml vials, 3 ml SoloStar injectable pens, and a 3 ml cartridge system. Insulin glargine is given only by subcutaneous injection.
How should I keep insulin glargine stored?
- Unopened vials, SoloStar pens, and cartridge systems should be refrigerated between 2 C and 8 C (36 F and 46 F).
- Unopened vials, SoloStar pens, and cartridge systems, if refrigerated, are good until the expiration dates.
- Unopened vials, SoloStar pens, and cartridge systems, stored at room temperature, are good for 28 days.
- Opened vials and cartridge systems can be refrigerated or stored at room temperature below 30 C (86 F).
- Cartridge systems inserted into the insulin delivery device and SoloStar pens should be stored only at room temperature below 30 C (86 F).
- Opened vials, SoloStar pens, and cartridge systems are good for 28 days.
Insulin glargine (Lantus) is an injectable form of long-lasting insulin that is prescribed to regulate blood sugar levels in individuals with type 1 and type 2 diabetes. Side effects, drug interactions, dosing, storage, and pregnancy safety information should be reviewed prior to taking any medication.
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Common Medical Abbreviations List
Doctors, pharmacists, and other health-care professionals use abbreviations, acronyms, and other terminology for instructions and information in regard to a patient's health condition, prescription drugs they are to take, or medical procedures that have been ordered. There is no approved this list of common medical abbreviations, acronyms, and terminology used by doctors and other health- care professionals. You can use this list of medical abbreviations and acronyms written by our doctors the next time you can't understand what is on your prescription package, blood test results, or medical procedure orders. Examples include: ANED: Alive no evidence of disease. The patient arrived in the ER alive with no evidence of disease. ARF: Acute renal (kidney) failure cap: Capsule. CPAP: Continuous positive airway pressure. A treatment for sleep apnea. DJD: Degenerative joint disease. Another term for osteoarthritis. DM: Diabetes mellitus. Type 1 and type 2 diabetes HA: Headache IBD: Inflammatory bowel disease. A name for two disorders of the gastrointestinal (BI) tract, Crohn's disease and ulcerative colitis JT: Joint N/V: Nausea or vomiting. p.o.: By mouth. From the Latin terminology per os. q.i.d.: Four times daily. As in taking a medicine four times daily. RA: Rheumatoid arthritis SOB: Shortness of breath. T: Temperature. Temperature is recorded as part of the physical examination. It is one of the "vital signs."
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
Low Blood Sugar (Hypoglycemia)
Low blood sugar, or hypoglycemia, is a syndrome in which a person's blood sugar is dangerously low. People with type 1 and type 2 diabetes are at risk for this condition. There are other diseases that can cause a person's blood sugar levels to go too low, for example, pancreatitis, Cushing's syndrome, and pancreatic cancer. Symptoms and signs that your blood sugar levels are too low include palpitations, trembling, intense hunger, sweating, nervousness, and weakness. If your blood sugars become too low, use these nearby as a quick treatment table sugar, soda, juice, and glucose tablets.
High Blood Sugar (Hyperglycemia)
Hyperglycemia or high blood sugar is a serious health problem for diabetics. There are two types of hyperglycemia, 1) fasting, and 2)postprandial or after meal hyperglycemia. Hyperglycemia can also lead to ketoacidosis or hyperglycemic hyperosmolar nonketotic syndrome (HHNS). There are a variety of causes of hyperglycemia in people with diabetes. Symptoms of high blood sugar may include increased thirst, headaches, blurred vision, and frequent urination.Treatment can be achieved through lifestyle changes or medications changes. Carefully monitoring blood glucose levels is key to prevention.
Type 2 Diabetes
Type 2 diabetes is a chronic condition that may be reversible with diet and lifestyle changes. Symptoms include excessive thirst, frequent urination, weight loss, fatigue, and an unusual odor to your urine. Most people don't know they have type 2 diabetes until they have a routine blood test. Treatment options include medications, a type 2 diabetes diet, and other lifestyle changes.
Gestational Diabetes (Diabetes during Pregnancy))
Learning how to avoid gestational diabetes is possible and maintaining a healthy weight and diet before and during pregnancy can help. Discover risk factors, tests and treatments for, and signs and symptoms of gestational diabetes.
Insulin Resistance (Symptoms, Causes, Diagnosis, Treatment, and Reversal))
Insulin resistance is the diminished ability of cells to respond to the action of insulin in transporting glucose (sugar) from the bloodstream into muscle and other tissues. There are no signs or symptoms of insulin resistance. Causes of insulin can include conditions such as stress, obesity, metabolic syndrome, and steroid use. Some of the risk factors for insulin resistance include fatty liver, heart disease, strokes, peripheral vascular disease, high cholesterol, and smoking. Treatment for insulin resistance are lifestyle changes and if necessary, medication.
Diabetes Treatment: Medication, Diet, and Insulin
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with: insulin, exercise, and a diabetic diet. Type 2 diabetes is first treated with: weight reduction, a diabetic diet, and exercise. When these measures fail to control the elevated blood sugar, oral medications are used. If oral medications are still insufficient, insulin medications are considered.
Type 1 vs. Type 2 Diabetes: Differences
Diabetes mellitus is a metabolic condition in which a person's blood sugar (glucose) levels are too high. Over 29.1 million children and adults in the US have diabetes. Of that, 8.1 million people have diabetes and don't even know it. Type 1 diabetes (insulin-dependent, juvenile) is caused by a problem with insulin production by the pancreas. Type 2 diabetes (non-insulin dependent) is caused by: Eating a lot of foods and drinking beverages with simple carbohydrates (pizza, white breads, pastas, cereals, pastries, etc.) and simple sugars (donuts, candy, etc.) Consuming too many products with artificial sweeteners (We found out that they are bad for us!) Lack of activity Exercise Stress Genetics While the signs and symptoms of both types of diabetes are the same, which include: Increased urination Increased hunger Increased thirst Unexplained weight loss. However, the treatments are different. Type 1 diabetes is insulin dependent, which means a person with this type of diabetes requires treatment with insulin. People with type 2 diabetes require medication, lifestyle changes like eating a healthy diet, and getting regular exercise.
Diabetic Ketoacidosis (Causes, Symptoms, Treatment, Complications)
Diabetic ketoacidosis (DKA) is a complication of type 1 diabetes that is life threatening. If a person thinks they may have diabetic ketoacidosis they should seek medical care immediately. Diabetic ketoacidosis happens when a person's insulin levels in the blood become dangerously low. Symptoms of diabetic ketoacidosis include dehydration, abdominal pain, confusion, and nausea and vomiting. Diabetic ketoacidosis needs medical treatment. It cannot be treated at home.
Type 1 Diabetes (Symptoms, Causes, Diet, Treatment, Life Expectancy)
Type 1 diabetes mellitus (juvenile) is an auto-immune disease with no known cause at this time, although there are a few risk factors. Symptoms of type 1 diabetes include frequent urination, unintentional weight loss, dry and itchy skin, vision problems, wounds that heal slowly, and excessive thirst. Type 1 diabetes is diagnosed with blood tests. A healthy lifestyle and controlling blood glucose levels can improve life expectancy.
Diabetes Foot Problems
Diabetes related foot problems can affect your health with two problems: diabetic neuropathy, where diabetes affects the nerves, and peripheral vascular disease, where diabetes affects the flow of blood. Common foot problems for people with diabetes include athlete's foot, fungal infection of nails, calluses, corns, blisters, bunions, dry skin, foot ulcers, hammertoes, ingrown toenails, and plantar warts.
Eye Problems and Diabetes
Diabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
Sex, Urinary, and Bladder Problems of Diabetes
Having diabetes can mean early onset and increased severity of bladder symptoms (urinary incontinence and urinary tract infections) and changes in sexual function. Men may have erectile dysfunction; and women may have problems with sexual response and vaginal lubrication. Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.
Diabetes and Kidney Disease
In the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. albumin and eGFR are two key markers for kidney disease in people with diabetes. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease. For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
Tips for Managing Type 1 and 2 Diabetes at Home
Managing your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the complications of diabetes. Information about exercise, diet, and medication will help you manage your diabetes better. Blood glucose reagent strips, blood glucose meters, urine glucose tests, tests for urinary ketones, continuous glucose sensors, and Hemoglobin A1C testing information will enable you to mange your diabetes at home successfully.
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Treatment & Diagnosis
Medications & Supplements
- Metformin vs. Januvia
- Types of Insulin Medications for Diabetes
- Insulin for Diabetes Treatment (Types, Side Effects, and Preparations)
- How Long Does Insulin Last After Injection?
- Metformin vs. Lantus
- Precose (acarbose)
- What Is Intravenous Insulin Therapy?
- How Do You Give Intravenous Insulin Therapy?
- Side Effects of Lantus (insulin glargine)
- Types of Diabetes Type I And II Medications
Prevention & Wellness
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.