- What is INSULIN GLARGINE-INJECTABLE, and how does it work (mechanism of action)?
- What brand names are available for INSULIN GLARGINE-INJECTABLE?
- Is INSULIN GLARGINE-INJECTABLE available as a generic drug?
- Do I need a prescription for INSULIN GLARGINE-INJECTABLE?
- What are the side effects of INSULIN GLARGINE-INJECTABLE?
- What is the dosage for INSULIN GLARGINE-INJECTABLE?
- Which drugs or supplements interact with INSULIN GLARGINE-INJECTABLE?
- Is INSULIN GLARGINE-INJECTABLE safe to take if I'm pregnant or breastfeeding?
- What else should I know about INSULIN GLARGINE-INJECTABLE?
What is INSULIN GLARGINE-INJECTABLE, and how does it work (mechanism of action)?
Insulin glargine is a bioengineered (man-made) injectable form of long-acting insulin that is used to regulate sugar (glucose) levels in type 1 and type 2 diabetes. Individuals with type 1 diabetes do not produce insulin on their own; and individuals with type 2 diabetes do not produce enough insulin, or insulin is not as effective due to insulin resistance.
Insulin glargine works the same way as natural human insulin, but it's action lasts longer. It helps diabetic patients regulate glucose or sugar in the body. Insulin glargine works by promoting movement of sugar from blood into body tissues and also stops sugar production in liver. Insulin glargine is man-made insulin that mimics the actions of human insulin.
The FDA approved insulin glargine in April 2000.
What are the side effects of INSULIN GLARGINE-INJECTABLE?
Common side effects of insulin glargine are:
Local allergic reactions that may occur at the injection sites are:
Long term use of insulin glargine can lead to thickening of fat tissues at the injection site.
Severe allergic reactions are:
- Swelling under the skin
- Very low blood pressure
- Bronchospasm (tightening of chest that leads to difficulty breathing)
Individuals should contact a healthcare professional if they experience any of the above reactions.
Quick GuideType 2 Diabetes Diagnosis, Treatment, Medication
Which drugs or supplements interact with INSULIN GLARGINE-INJECTABLE?
There are many drugs that do not directly interfere with insulin glargine, but they may affect glucose breakdown in the body. This necessitates adjustments of insulin glargine doses.
Other drugs that can decrease the blood-sugar-lowering effect of insulin glargine are:
Is INSULIN GLARGINE-INJECTABLE safe to take if I'm pregnant or breastfeeding?
Safe and effective use of insulin glargine is not established for pregnant females.
It is not known whether insulin glargine enters breast milk; therefore, it should be used with caution in females who are breastfeeding.
What else should I know about INSULIN GLARGINE-INJECTABLE?
What preparations of INSULIN GLARGINE-INJECTABLE are available?
Insulin glargine is available as 100 units/ml. Insulin glargine is supplied in 10 ml vials, 3 ml SoloStar injectable pens, and a 3 ml cartridge system. Insulin glargine is given only by subcutaneous injection.
How should I keep INSULIN GLARGINE-INJECTABLE stored?
- Unopened vials, SoloStar pens, and cartridge systems should be refrigerated between 2 C and 8 C (36 F and 46 F).
- Unopened vials, SoloStar pens, and cartridge systems, if refrigerated, are good until the expiration dates.
- Unopened vials, SoloStar pens, and cartridge systems, stored at room temperature, are good for 28 days.
- Opened vials and cartridge systems can be refrigerated or stored at room temperature below 30 C (86 F).
- Cartridge systems inserted into the insulin delivery device and SoloStar pens should be stored only at room temperature below 30 C (86 F).
- Opened vials, SoloStar pens, and cartridge systems are good for 28 days.
REFERENCE: FDA Prescribing Information.
Quick GuideType 2 Diabetes Diagnosis, Treatment, Medication
Insulin glargine (Lantus) is an injectable form of long-lasting insulin that is prescribed to regulate blood sugar levels in individuals with type 1 and type 2 diabetes. Side effects, drug interactions, dosing, storage, and pregnancy safety information should be reviewed prior to taking any medication.
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Common Medical Abbreviations and Terms
Doctors, pharmacists, and other health-care professionals use abbreviations, acronyms, and other terminology for instructions and information in regard to a patient's health condition, prescription drugs they are to take, or medical procedures that have been ordered. There is no approved this list of common medical abbreviations, acronyms, and terminology used by doctors and other health- care professionals. You can use this list of medical abbreviations and acronyms written by our doctors the next time you can't understand what is on your prescription package, blood test results, or medical procedure orders. Examples include:
- ANED: Alive no evidence of disease. The patient arrived in the ER alive with no evidence of disease.
- ARF: Acute renal (kidney) failure
- cap: Capsule.
- CPAP: Continuous positive airway pressure. A treatment for sleep apnea.
- DJD: Degenerative joint disease. Another term for osteoarthritis.
- DM: Diabetes mellitus. Type 1 and type 2 diabetes
- HA: Headache
- IBD: Inflammatory bowel disease. A name for two disorders of the gastrointestinal (BI) tract, Crohn's disease and ulcerative colitis
- JT: Joint
- N/V: Nausea or vomiting.
- p.o.: By mouth. From the Latin terminology per os.
- q.i.d.: Four times daily. As in taking a medicine four times daily.
- RA: Rheumatoid arthritis
- SOB: Shortness of breath.
- T: Temperature. Temperature is recorded as part of the physical examination. It is one of the "vital signs."
Diabetes and Kidney DiseaseIn the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. albumin and eGFR are two key markers for kidney disease in people with diabetes. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease. For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
Diabetes Foot ProblemsLearn more about diabetes related foot problems. For people with diabetes, too much glucose in the blood can cause serious foot complications such as nerve damage, infection, and ulcers. Find tips for proper foot care to help prevent serious complications.
Diabetes MellitusDiabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
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Diabetes TreatmentThe major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with:
- and a diabetic diet.
- weight reduction,
- a diabetic diet,
- and exercise.
Foot Problems (Diabetes)Diabetes related foot problems can affect your health with two problems: diabetic neuropathy, where diabetes affects the nerves, and peripheral vascular disease, where diabetes affects the flow of blood. Common foot problems for people with diabetes include athlete's foot, fungal infection of nails, calluses, corns, blisters, bunions, dry skin, foot ulcers, hammertoes, ingrown toenails, and plantar warts.
Gestational diabetes is a condition that is first recognized during pregnancy and is characterized by high blood sugar. Approximately 4% of all pregnancies are diagnosed with gestational diabetes. Low blood sugar is prevented by hormones produced by the placenta during a woman's pregnancy. The actions of insulin are stopped by these hormones. Gestational diabetes is the result of the pancreas' inability to produce enough insulin to overcome the effect of the increase hormones during pregnancy. Risk factors for gestational diabetes include:
- Previous history of gestational diabetes
- Having a parent or sibling with type 2 diabetes
- Personal history of PCOS
There typically are no signs and symptoms of gestational diabetes. Treatment includes diet modifications and if necessary, insulin.
HyperglycemiaHyperglycemia or high blood sugar is a serious health problem for diabetics. There are two types of hyperglycemia, 1) fasting, and 2)postprandial or after meal hyperglycemia. Hyperglycemia can also lead to ketoacidosis or hyperglycemic hyperosmolar nonketotic syndrome (HHNS). There are a variety of causes of hyperglycemia in people with diabetes. Symptoms include:
- increased thirst,
- blurred vision,
- frequent urination and more.
Low blood sugar, or hypoglycemia, is a syndrome in which a person's blood sugar is dangerously low. People with type 1 and type 2 diabetes are at risk for this condition. There are other diseases that can cause a person's blood sugar levels to go too low, for example, pancreatitis, Cushing's syndrome, and pancreatic cancer. Symptoms and signs that your blood sugar levels are too low include:
- Intense hunger
If your blood sugars become too have the following nearby as a quick treatment.
- Table sugar
- Glucose tablets
Insulin resistance is the diminished ability of cells to respond to the action of insulin in transporting glucose (sugar) from the bloodstream into muscle and other tissues. There are no signs or symptoms of insulin resistance. Causes of insulin can include conditions such as
- metabolic syndrome, and
- steroid use.
Some of the risk factors for insulin resistance include fatty liver, heart disease, strokes, peripheral vascular disease, high cholesterol, and smoking. Treatment for insulin resistance are lifestyle changes and if necessary, medication.
Blood Sugar SwingsLearn to better control your glucose levels by preventing blood sugar swings. Beware of caffeine, sugary foods, spices, exercise, sleep, alcohol, and stress because these can all impact blood sugar levels and increase diabetes complications
Type 2 Diabetes
Type 2 diabetes is a condition in which a person's pancreas does not produce enough insulin to meet the needs of the body. Causes of type 2 diabetes are a sedentary lifestyle, eating excess sugar and carbohydrates, lack of exercise, being overweight, and genetics. Symptoms of type 2 diabetes are often subtle, but may include:
- Urine odor
- Unintentional weight gain or loss
- Frequent urination
- Dark skin under the chin, armpits, or groin
Type 2 diabetes is diagnosed by a blood test. Treatment for type 2 diabetes are a healthy type 2 diabetes diet, exercise, stress reduction, and medication. Type 2 diabetes is a preventable disease. Incorporating healthy lifestyle changes (for example, eating a healthy diet, exercising more, and reducing stress) can prevent type 2 diabetes.
Type 2 Diabetes SlideshowLearn about type 2 diabetes warning signs, symptoms, diagnosis, and treatment options. Read how diet and exercise can help manage type 2 diabetes.