- Side Effects
- Drug Interactions
What is Inqovi (decitabine and cedazuridine), and what is it used for?
Inqovi (decitabine and cedazuridine) is a prescription medicine used to treat adults with myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML). Your healthcare provider will determine if Inqovi can treat your type of MDS.
It is not known if Inqovi is safe or effective in children.
What are the side effects of Inqovi?
Inqovi may cause serious side effects, including:
- Low blood cell counts. Low blood counts (white blood cells, platelets, and red blood cells) are common with Inqovi but can also be serious and lead to infections that may be life-threatening. If your blood cell counts are too low, your healthcare provider may need to delay treatment with Inqovi, lower your dose of Inqovi, or in some cases give you a medicine to help treat low blood cell counts. Your healthcare provider may need to give you antibiotic medicines to prevent or treat infections or fever while your blood cell counts are low. Your healthcare provider will check your blood cell counts before you start treatment and regularly during treatment with Inqovi. Call your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with Inqovi:
The most common side effects of Inqovi include:
- low white blood cell count (leukopenia)
- low platelets in your blood (thrombocytopenia)
- low white blood cell count (neutropenia)
- low red blood cell count (anemia)
- muscle pain
- pain or sores in your mouth or throat
- joint pain
- shortness of breath
- fever with low white blood cell count (febrile neutropenia)
- swelling of arms or legs
- decreased appetite
- upper respiratory tract infection
- changes in liver function tests
Inqovi may affect fertility in men. Talk to your healthcare provider if this is a concern for you.
These are not all of the possible side effects of Inqovi. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the dosage for Inqovi?
Do NOT substitute Inqovi for an intravenous decitabine product within a cycle.
The recommended dosage of Inqovi is 1 tablet (containing 35 mg decitabine and 100 mg cedazuridine) orally once daily on Days 1 through 5 of each 28-day cycle for a minimum of 4 cycles until disease progression or unacceptable toxicity. A complete or partial response may take longer than 4 cycles.
Instruct patients of the following:
- Take Inqovi at the same time each day.
- Swallow tablets whole. Do not cut, crush, or chew tablets.
- Do not consume food 2 hours before and 2 hours after each dose.
- Take one tablet a day for 5 days in each cycle. If the patient misses a dose within 12 hours of the time it is usually taken, instruct patiients to take the missed dose as soon as possible and then to resume the normal daily dosing schedule. Extend the dosing period by one day for every missed dose to complete 5 daily doses for each cycle.
- Do not take an additional dose if vomiting occurs after Inqovi administration but continue with the next schedule dose.
Inqovi is a hazardous drug. Follow applicable special handling and disposal procedures.
Monitoring And Dosage Modifications For Adverse Reactions
Hematologic Adverse Reactions
Obtain complete blood cell counts prior to initiating Inqovi and before each cycle. Delay the next cycle if absolute neutrophil count (ANC) is less than 1,000/µL and platelets are less than 50,000/µL in the absence of active disease. Monitor complete blood cell counts until ANC is 1,000/µL or greater and platelets are 50,000/µL or greater.
- If hematologic recovery occurs (ANC at least 1,000/μL and platelets at least 50,000/μL) within 2 weeks of achieving remission, continue Inqovi at the same dose.
- If hematologic recovery does not occur (ANC at least 1,000/μL and platelets at least 50,000/μL) within 2 weeks of achieving remission,
- Delay Inqovi for up to 2 additional weeks AND
- Resume at a reduced dose by administering Inqovi on Days 1 through 4. Consider further dose reductions in the order listed in Table 1 if myelosuppression persists after a dose reduction. Maintain or increase dose in subsequent cycles as clinically indicated.
Table 1: Recommended Inqovi Dose Reductions for Myelosuppression
|First||1 tablet orally once daily on Days 1 through 4|
|Second||1 tablet orally once daily on Days 1 through 3|
|Third||1 tablet orally once daily on Days 1, 3 and 5|
Manage persistent severe neutropenia and febrile neutropenia with supportive treatment.
Non-Hematologic Adverse Reactions
Delay the next cycle for the following non-hematologic adverse reactions and resume at the same or reduced dose upon resolution:
What drugs interact with Inqovi?
Effects Of Inqovi On Other Drugs
Drugs Metabolized by Cytidine Deaminase
- Cedazuridine is an inhibitor of the cytidine deaminase (CDA) enzyme. Coadministration of Inqovi with drugs that are metabolized by CDA may result in increased systemic exposure with potential for increased toxicity of these drugs.
- Avoid coadministration of Inqovi with drugs that are metabolized by CDA.
Inqovi contraindications, and pregnancy and breastfeeding safety
- Based on findings from human data, animal studies, and its mechanism of action, Inqovi can cause fetal harm when administered to a pregnant woman.
- Inqovi are no data on the presence of cedazuridine, decitabine, or their metabolites in human milk or on their effects on the breastfed child or milk production. Because of the potential for serious adverse reactions in the breastfed child, advise women not to breastfeed during treatment with Inqovi and for at least 2 weeks after the last dose.
Latest Cancer News
Daily Health News
Inqovi (decitabine and cedazuridine) is a prescription medication used to treat adults with myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML). Serious side effects of Inqovi include low blood cell counts. It is not known if Inqovi is safe or effective in children.
Multimedia: Slideshows, Images & Quizzes
Understanding Cancer: Metastasis, Stages of Cancer, and More
Learn the basics about cancer including types, causes, how it spreads, symptoms and signs, stages and treatment options. Read...
Blood Cancer Types: Leukemia, Lymphomas, Myelomas, and More
Types of blood cancers include leukemia, lymphomas, multiple myelomas, and others discussed in this slideshow. Symptoms may...
Signs of Cancer in Women: Symptoms You Can't Ignore
Colon and stomach cancer symptoms can surprise women but can be treated if detected early. Learn about breast cancer signs and...
Cancer-Fighting Foods: Resveratrol, Green Tea, and More
Experts have praised certain foods for their ability to reduce cancer risks. Learn which foods and eating strategies may help...
Cancer: Guide to Leukemia
Learn about the common types and stages of leukemia, who gets it, symptoms, tests, treatments, and more. People with blood cancer...
Cancer: Symptoms of Common Cancers in Men
Can men get breast cancer? Cancer symptoms men need to watch out for include skin changes, difficulty swallowing, rapid weight...
Cancer: What Complications Can Brain Cancer Cause?
Brain cancer can cause many different complications, from seizures to extreme fatigue. Use this WebMD slideshow to learn how it...
What do you know about leukemia? Did you know there are different types? What are the symptoms? Take the Leukemia Quiz and test...
Top 10 Cancers Quiz
Take this quiz to learn the causes of cancer. Get the facts about the causes, symptoms, and treatments for the world's most...
Cancer: How to Lower and Cut Your Risk of Cancer
About a third of all cases of cancer can be prevented. Find out how to lower your chances of getting it.
Cancer: Guide to Testicular Cancer
Testicular cancer is one of the most common cancers for men ages 15 to 35, but it's very treatable. WebMD explains when to see...
Cancer: Does This Cause Cancer?
Everything gives you cancer, right? Not really. WebMD's slide show tells you about the research into cancer and cell phones,...
Cancer: Cancer 'Remedies' That Don't Work
You may have read about an all-natural cure for cancer. While many therapies are helpful, some aren't worth your time or money....
Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Bone cancer is a rare type of cancer that occurs in cells that make up the bones. Primary bone cancer that arises in bone cells is different than metastatic bone cancer, which is cancer that arises in another part of the body and then spreads to the bones. Hereditary and environmental factors likely contribute to the risk of bone cancer. Signs and symptoms of bone cancer may include pain, the presence of a mass or lump, and bone fractures. There are different types of bone cancer (osteosarcoma, chondrosarcoma, Ewing's sarcoma, pleomorphic sarcoma, fibrosarcoma). Treatment for bone cancer may include surgical removal of the tumor, chemotherapy, radiation, and/or a stem cell transplant. The prognosis for bone cancer depends on the type of cancer and the extent of spread.
Can Cancer Be Detected by a Blood Test?
While blood tests can’t absolutely detect all cancers, certain blood tests can give your doctor an idea of how your organs are functioning and if they have been affected by cancer.
What Is the Life Expectancy of a Person With Leukemia?
Leukemia is a group of cancers of the blood affecting the white blood cells. White blood cells are the infection-fighting cells of the body. In adults, leukemia is most common in people older than 55 years, with the average age of diagnosis being 66 years. It is also one of the most common cancers in children and adults younger than 20 years. The survival rate is higher for younger people.
Leukemia is a type of cancer of the blood cells in which the growth and development of the blood cells are abnormal. Strictly speaking, leukemia should refer only to cancer of the white blood cells (the leukocytes) but in practice it can apply to malignancy of any cellular element in the blood or bone marrow, as in red cell leukemia (erythroleukemia).
Cancer Risk Factors and Causes
Though it's difficult to say why some people develop cancer while others don't, research shows that certain risk factors increase a person's odds of developing cancer. These risk factors include growing older, family history of cancer, diet, alcohol and tobacco use, and exposure to sunlight, ionizing radiation, certain chemicals, and some viruses and bacteria.
What Is the Most Survivable Cancer?
Most of the cancers, if diagnosed and treated in early stages, are definitely survivable. The main issue is timely detection. Many types of cancer are still very difficult to detect in early stages because of their location, vague symptoms and late reporting by patients. Higher survival rates are largely because of several factors including not only early detection but also better treatment approaches.
Second Source article from Government
Second Source article from Government
How Does Leukemia Kill?
Leukemia is a cancer of the white blood cells of the bone marrow. Patients with leukemia have an over-production of a particular blood cell type in the body, the white blood cells (cells that fight infection, and provide immunity).
Survival Rate for Acute Lymphoblastic Leukemia
The prognosis depends on the type of leukemia, the extent of the disease, age of the patient, and the general condition of the patient. Some patients can go into complete remission. The average five-year survival rate of leukemia is 60-65%.
At What Stage of Cancer is Chemotherapy Used?
The decision to use chemotherapy may vary depending on the aggressiveness, stage and type of cancer. Usually, chemotherapy may be used for all stages in most cancer types. Chemotherapy is a type of medicine or combination of medications that is used to treat or kill cancer cells.
Cancer fatigue is a lack of energy that is caused by cancer or cancer treatment, including chemotherapy, radiation, biological therapy, or bone marrow transplantation. Strategies to combat cancer fatigue include scheduling rest, pacing oneself, planning ahead and prioritizing work and activities, eating the right foods, exercising, and practicing proper body mechanics.
Certain behavioral, lifestyle, and environmental factors contribute to cancer. Cancer prevention involves modifying these factors to decrease cancer risk. Tobacco use, alcohol consumption, physical inactivity, inadequate fruit and vegetable intake, and obesity increase the risk of certain cancers. Vaccines, genetic testing, and cancer screening also play a role in cancer prevention.
What Are the Stages of Chronic Lymphocytic Leukemia?
Chronic lymphocytic leukemia is a cancer of the blood and bone marrow. With this type of cancer, the marrow creates too many abnormal lymphocytes. There are five stages of chronic lymphocytic leukemia.
Can Cancer Be Detected in Blood Tests?
When a person is suspected to have cancer, doctors may perform a variety of tests to help diagnose cancer. Different types of blood tests are done to check for abnormal cells, cancer cells, proteins, tumor markers or other substances made by the cancer cells. This helps determine if a person has cancer or any precancerous condition. Blood tests may also indicate if other organs of the body have been affected by cancer.
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy, radiation, or surgery can also cause pain. Over-the-counter pain relievers, prescription medications, radiation, biofeedback, and relaxation techniques are just some treatments for cancer pain.
Guide for COVID-19 Vaccine for Cancer Patients
The authorities have jointly agreed that patients on active cancer treatment are at a higher risk of COVID-19 infection and complications. Hence, there is a necessity to prioritize patients with cancer for the COVID-19 vaccine.
Childhood Acute Lymphoblastic Leukemia (ALL)
Childhood acute lymphoblastic leukemia is the most common type of cancer in children. Symptoms and signs include fever, easy bruising, bone or joint pain, weakness, loss of appetite, and painless lumps in the neck, underarm, stomach, or groin. Treatment depends upon staging and may include chemotherapy, radiation, or stem cell transplant.
Leukemia: Signs, Symptoms, And Complications
Leukemia results when the genetic material (DNA) of a single cell in the bone marrow transforms, this is called a mutation. A mutated cell does not perform body function, but it eats away the nutrition meant for the normal cells.
How Can You Get Cancer?
Cancer is the second leading cause of death worldwide. It refers to uncontrolled growth of the cells that results in overgrowth of the organ it affects along with a tendency to spread to nearby and distant sites in the body.
Treatment & Diagnosis
- Bone Cancer
- Cancer Survival and Attitude with Hamilton Jordan
- Cancer: Confronting Cancer with Humor
- Childhood Acute Lymphoblastic Leukemia (C-ALL)
- Cancer: Journaling to Save Your Life
- Cancer Treatment: Writing to Heal with Margie Davis
- Cancer and Green Tea
- Cancer: The Importance of Joining a Cancer Support Group with Selma Schimmel
- Cancer Patients Need Proper Diet and Exercise
- Cancer: Living Well Despite with Win Boerckel
- Cancer Pain Management with Ann Reiner
- Cancers: Children's Cancers
- Cancer: Childhood Cancer Survivors
- Cancer Research: Going the Distance
- Leukemia FAQs
- Cancer FAQs
- Evolution of Treatment for a Rare Type of Leukemia
- Gleevec and Chronic Myeloid Leukemia
- How Familes Cope with a Leukemia Diagnosis
- Coping with a Bad Disease - Community Counts
- A Family's Leukemia Diary - Coping
- Cancer Survivor?
- Cancer,Stroke & Heart Attack Risks- ReducedThrough Walking
- Cancer Care in the Elderly
- Is Multiple Myeloma the Same as Leukemia?
- Can Folic Acid Prevent Leukemia?
- Does Folic Acid Prevent Leukemia?
- Does Stress Cause Cancer?
- Early Bone Cancer Symptoms
- Complementary and Alternative Cancer Treatments
- Bone Cancer Treatment Options and Their Side Effects
- 10 Cancer Symptoms That Men Ignore
- Chronic Myelogenous Leukemia (CML)
- Cancer Prevention: The Anticancer Diet
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.