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- What is infliximab-dyyb, and how does it work?
- What are the uses for infliximab-dyyb?
- What are the side effects of infliximab-dyyb?
- What is the dosage for infliximab-dyyb?
- Which drugs or supplements interact with infliximab-dyyb?
- Is infliximab-dyyb safe to use during pregnancy or while breastfeeding?
- What else should I know about infliximab-dyyb?
What is infliximab-dyyb, and how does it work?
- Infliximab-dyyb is an antibody administered intravenously and is used for treating several chronic inflammatory diseases such as Crohn's disease, psoriatic arthritis, or rheumatoid arthritis. It is a biosimilar version of the biologic drug, infliximab (Remicade). Biologic drugs are drugs that are produced by natural, biologic processes, for example, within cells. A biosimilar version is a medication that works like the original biologic drug but is manufactured by a different company by a different process. Infliximab-dyyb works by blocking the effects of tumor necrosis factor alpha (TNF alpha), a substance made by cells of the body which has an important role in promoting inflammation. There are two other injectable drugs that block TNF alpha--adalimumab (Humira) and etanercept (Enbrel).
- Infliximab-dyyb reduces the signs and symptoms of inflammation by blocking the action of TNF-alpha. Infliximab-dyyb does not cure Crohn's disease, psoriatic arthritis, or rheumatoid arthritis. Infliximab-dyyb can retard the destruction of joints by rheumatoid arthritis.
- The FDA approved Infliximab-dyyb in April 2016.
What brand names are available for infliximab-dyyb?
Inflectra is the brand name available for infliximab-dyyb in the US.
Is infliximab-dyyb available as a generic drug?
No, this drug is not available in generic form.
Do I need a prescription for infliximab-dyyb?
Yes, a patient must obtain a prescription by a doctor or other health care professional to receive this medication.
What are the uses for infliximab-dyyb?
Infliximab-dyyb is a medication that belongs to the class of drugs called biologics, and is approved for the treatment of the following health conditions.
- Crohn's and pediatric Crohn's disease: Reducing signs and symptoms and inducing and maintaining clinical remission in children and adult patients with moderate to severe disease who did not fully respond to conventional therapy. It also is used for the treatment of adult patients with fistulas due to Crohn's.
- Ulcerative Colitis: Reducing signs and symptoms and inducing and maintaining clinical remission and mucosal healing (healing of the lining of the colon), and eliminating corticosteroid use in adult patients with ulcerative colitis who did not fully respond to conventional therapy.
- Rheumatoid Arthritis: Infliximab-dyyb is used in combination with the medication methotrexate (Trexall, Rheumatrex) to reduce signs and symptoms, reduce structural damage, and slow the progression of rheumatoid arthritis.
- Ankylosing Spondylitis: Reducing signs and symptoms of ankylosing spondylitis (a type of arthritis).
- Psoriatic Arthritis: Reducing signs and symptoms, reducing structural damage, and slowing the progression of active psoriatic arthritis.
- Plaque Psoriasis: It is used for treatment of adult patients with chronic severe plaque psoriasis who need oral or injectable medications when other oral or injectable medications are medically less appropriate.
What are the side effects of infliximab-dyyb?
WARNING: Infliximab-dyyb is associated with increased risk of serious infections leading to hospitalization or death. These infections include:
- Tuberculosis (TB)
- Bacterial sepsis
- Invasive fungal infections (such as histoplasmosis)
- Infections due to other opportunistic pathogens. Infliximab-dyyb should be stopped if a serious infection develops.
- Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients received treatment with tumor necrosis factor (TNF) blockers, including infliximab products.
- Post marketing cases of fatal hepatosplenic T-cell lymphoma (HSTCL) have been reported in patients treated with TNF blockers, including infliximab products.
Common side effects of infliximab-dyyb include:
- Upper respiratory tract infections
- Urinary tract infections (UTIs)
- Back pain
- Abdominal pain
- Low or high blood pressure
- Chest pain
- Difficulty breathing
Serious side effects of infliximab-dyyb include:
- Hepatosplenic T-cell lymphoma
- Serious bacterial infections (sepsis)
- Serious fungal infections
- Liver toxicity
- Heart failure
- Optic neuritis
- Severe allergic reactions (anaphylaxis)
- Sun sensitivity
- Pulmonary edema
- Severe infusion reactions
- Lupus erythematosus
- Interstitial lung disease
- Hepatitis B virus (HBV) reactivation
- Demyelinating disease
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What is the dosage for infliximab-dyyb?
Infliximab-dyyb is administered intravenously (IV).
- Crohn's disease: The recommended dose is a 5 mg/kg at 0, 2, and 6 weeks and then 5 mg/kg every 8 weeks for Crohn's in adult or pediatric patients. Adults who initially responded but then relapsed may be treated with 10 mg/kg.
- Rheumatoid arthritis: The recommended dose for the treatment of rheumatoid arthritis is 3 mg/kg at 0, 2, and 6 weeks followed by 3 mg/kg every 8 weeks. Infliximab-dyyb should be combined with methotrexate. If response is incomplete, up to 10 mg/kg or treating every 4 weeks may be tried for this type of arthritis.
- Ulcerative colitis, psoriatic arthritis, and plaque psoriasis: are treated with a 5 mg/kg infusion at 0, 2, and 6 weeks and then 5 mg/kg every 8 weeks.
- Ankylosing spondylitis: treatment is with a 5 mg/kg infusion at 0, 2, and 6 weeks and then 5 mg/kg every 6 weeks.
Which drugs or supplements interact with infliximab-dyyb?
- Because this medication may reduce the response of the immune system, it should not be administered with vaccines containing live bacteria or viruses.
- Combining this drug with anakinra (Kineret), abatacept (Orencia) or tocilizumab (Actemra), drugs that also reduce the response of the immune system, may increase the risk of serious infections.
- This drug may indirectly alter blood levels of warfarin (Coumadin, Jantoven), cyclosporine (Neoral), and other medications that are metabolized by liver enzymes called CYP450 because the formation of these liver enzymes is affected by the level of cytokines.
Is infliximab-dyyb safe to use during pregnancy or while breastfeeding?
- Use of this drug in during pregnancy has not been adequately evaluated.
- It is not known if it is secreted in breast milk, and, therefore, if there are effects on the nursing infant.
What else should I know about infliximab-dyyb?
What preparations of infliximab-dyyb are available?
- This medication is available in powder for infusion: 100 mg
How should I keep infliximab-dyyb stored?
- Infliximab-dyyb should be refrigerated at 2 C - 8 C (36 F - 46 F).
- This medication should not be used after the expiration date. It does not contain a preservative.
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Related Disease Conditions
Ulcerative Colitis Diet Plan
An ulcerative colitis diet plan can help a person with the disease avoid foods and drinks that trigger flares. There also are foods that can soothe ulcerative colitis symptoms during a flare. Types of ulcerative colitis plans include a high-calorie diet, a lactose-free diet, a low-fat diet, a low-fiber diet (low-residue diet), or a low-salt diet. Self-management of ulcerative colitis using healthy lifestyle habits and a nutrient rich diet can be effective in management of the disease. Learn what foods to avoid that aggravate, and what foods help symptoms of the disease and increase bowel inflammation.
Psoriasis is a long-term skin condition that may cause large plaques of red, raised skin, flakes of dry skin, and skin scales. There are several types of psoriasis, including psoriasis vulgaris, guttate psoriasis, inverse psoriasis, and pustular psoriasis. Symptoms vary depending on the type of psoriasis the patient has. Treatment of psoriasis may include creams, lotions, oral medications, injections and infusions of biologics, and light therapy. There is no cure for psoriasis.
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease resulting in chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Early RA signs and symptoms include anemia, both sides of the body affected (symmetric), depression, fatigue, fever, joint deformity, joint pain, joint redness, joint stiffness, joint swelling, joint tenderness, joint warmth, limping, loss of joint function, loss of joint range of motion, and polyarthritis.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Ankylosing spondylitis is a type of arthritis that causes chronic inflammation of the spine. The tendency to develop ankylosing spondylitis is genetically inherited. Treatment incorporates medications, physical therapy, and exercise.
Ulcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Ulcerative colitis is closely related to Crohn's disease, and together they are referred to as inflammatory bowel disease. Treatment depends upon the type of ulcerative colitis diagnosed.
Inflammatory Bowel Disease (IBD)
The inflammatory bowel diseases (IBD) are Crohn's disease (CD) and ulcerative colitis (UC). The intestinal complications of Crohn's disease and ulcerative colitis differ because of the characteristically dissimilar behaviors of the intestinal inflammation in these two diseases.
What Is Crohn's Disease?
Crohn's disease is a chronic inflammatory disease, primarily involving the small and large intestine, but which can affect other parts of the digestive system as well. Abdominal pain, diarrhea, vomiting, fever, and weight loss are common symptoms.
Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms and signs include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Treatment involves anti-inflammatory medications and exercise.
Is Psoriasis Contagious?
Psoriasis is an incurable skin disease that causes reddish patches of skin topped with a thick layer of dry silvery scales. Psoriasis cannot spread and is not contagious.
Is Crohn's Disease Contagious?
Crohn's disease, a form of inflammatory bowel disease (IBD), and is characterized by symptoms and signs that include diarrhea, fever, weight loss, vomiting, and abdominal pain. Though Crohn's disease is not contagious it can spread throughout a person's gastrointestinal tract. An increase in the above symptoms and signs warrants a visit to a doctor's office.
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