- What is indapamide, and how does it work (mechanism of action)?
- What are the uses for indapamide?
- What are the side effects of indapamide?
- What is the dosage for indapamide?
- Which drugs or supplements interact with indapamide?
- Is indapamide safe to take if I'm pregnant or breastfeeding?
- What else should I know about indapamide?
What is indapamide, and how does it work (mechanism of action)?
Indapamide is a diuretic (water pill) that is used primarily for the treatment of high blood pressure. It works by preventing the kidney from reabsorbing (retaining in the body) salt and water that is destined to be eliminated in the urine. This results in increased urine output (diuresis). Indapamide also is thought to reduce the salt in the smooth muscle of the walls of blood vessels. (The salt ultimately is eliminated in the urine.) The loss of salt from the muscle causes the muscle to relax, and the relaxation of the vessels results in reduced blood pressure. Indapamide was approved by the FDA in 1983.
What brand names are available for indapamide?
Lozol (discontinued brand)
Is indapamide available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for indapamide?
What are the side effects of indapamide?
Common adverse side effects of indapamide are dehydration, and hypokalemia (low blood potassium due to elimination of potassium in the urine), which causes abnormal cardiac rhythms The most common symptom associated with hypokalemia is muscle weakness. Patients receiving indapamide may need potassium supplements to prevent hypokalemia. Hypomagnesemia (low blood magnesium) also may occur.
Other important side effects include:
- low blood pressure,
- excessive loss of sodium (particularly of concern in elderly patients),
- increased cholesterol (this effect tends to diminish with continued use),
- increased blood glucose,
- increased uric acid concentrations in the blood,
- blurred vision,
- tingling of the extremities,
- photosensitivity (skin rashes due to sunlight),
- irritability, and
What is the dosage for indapamide?
Indapamide is taken as a single daily dose, generally in the morning before breakfast. The recommended dose range is 1.25 to 5 mg once daily. It can be taken with or without food. Antacids have no effect on the activity of Indapamide.
Which drugs or supplements interact with indapamide?
Like other diuretics, indapamide can cause hypokalemia (low potassium) and hypomagnesemia (low magnesium). These changes can increase the risk of digoxin (Lanoxin) toxicity, possibly resulting in fatal abnormal heart rhythms. Use of amiodarone (Cordarone) and indapamide also can lead to cardiac arrhythmias. The ability of the kidney to eliminate lithium (Lithobid, Eskalith) is decreased in patients receiving diuretics, including indapamide. The use of these two drugs together could result in lithium toxicity.
Is indapamide safe to take if I'm pregnant or breastfeeding?
The use of indapamide in pregnancy has not been well studied. Physicians may elect to use it if its benefits are judged to outweigh its potential risks. The use of indapamide in nursing mothers has not been studied.
Indapamide (Lozol [Discontinued]) is a medication prescribed for the treatment of high blood pressure and edema that may result from congestive heart failure. Review side effects, drug interactions, and dosage information prior to taking this medication.
Related Disease Conditions
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Edema is swelling caused by fluid accumulation in the tissues of the body and occurs most often in the legs, feet, ankles, or hands. Learn about different types, symptoms, causes, and treatment.
Things to Know About High Blood Pressure Treatment
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.