IgA Nephropathy (Berger's Disease): Symptoms & Signs

Medically Reviewed on 10/26/2021

IgA nephropathy, also known as Berger's disease, is a chronic disease of the kidney that is characterized by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (specialized structures that filter the blood) in the kidney. It is more common in Caucasians and Asians than in other groups. IgA nephropathy is the most common cause of inflammation of the glomeruli of the kidney.

The most common sign of Berger's disease is hematuria (blood in the urine). The condition is most often diagnosed in people in their late teens or 20s, and it takes many years to progress to severe symptoms of renal failure. Advanced disease is characterized by swelling in the feet or hands or high blood pressure. Other associated symptoms and signs can include

  • flank pain,
  • frothy urine (from protein leakage into the urine), and
  • fever.

Cause of IgA Nephropathy (Berger's Disease)

The cause of Berger's disease is not understood.

Other iga nephropathy (berger's disease) symptoms


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.