Idebenone

Quick Guide to Dementia

What other names is Idebenone known by?

2,3-dimethoxy-5-methyl-6-(10-hydroxydecyl)-1,4-benzoquinone, Hydroxydecyl Benzoquinone, Idebenona, Idébénone.

What is Idebenone?

Idebenone is a man-made product similar to coenzyme Q-10.

Idebenone is used for Alzheimer's disease, liver disease, and heart disease; as well as a number of inherited disorders including Leber's disease (an eye condition), mitochondrial encephalomyopathies (nerve and muscle disorders), and Friedreich's ataxia (a nervous system disorder that worsens over time, producing gait and speech problems, and eventually leading toward heart disease and diabetes).

Possibly Effective for...

Insufficient Evidence to Rate Effectiveness for...

  • Friedreich's ataxia (an inherited progressive condition affecting the nerves that can lead to heart disease and diabetes). Some developing research suggests that taking idebenone may help control heart damage associated with Friedreich's ataxia. But other research hasn't shown this benefit. Idebenone does not appear to slow the progression of this condition.
  • Mitochondrial encephalomyopathies (a group of disorders that lead to muscle and nervous system problems). There is some research that suggests that taking idebenone might reduce symptoms in patients with some of these conditions.
  • Other conditions.
More evidence is needed to rate the effectiveness of idebenone for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Quick GuideDementia, Alzheimer's Disease, and Aging Brains

Dementia, Alzheimer's Disease, and Aging Brains

How does Idebenone work?

Idebenone seems to have antioxidant activity, and appears to protect a wide variety of cells from oxidative damage.

Are there safety concerns?

Idebenone seems safe for most people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of idebenone during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Dosing considerations for Idebenone.

The following doses have been studied in scientific research:

BY MOUTH:
  • For Alzheimer's disease: 90-120 mg of idebenone three times daily.
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Reviewed on 3/29/2011 12:35:40 PM

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