- Deep Vein Thrombosis Slideshow Pictures
- Take the DVT and PE Quiz
- Spider & Varicose Veins Pictures Slideshow
- What is idarucizumab, and how does it work (mechanism of action)?
- What are the uses for idarucizumab?
- What are the side effects of idarucizumab?
- What is the dosage for idarucizumab?
- Which drugs or supplements interact with idarucizumab?
- Is idarucizumab safe to take if I'm pregnant or breastfeeding?
- What else should I know about idarucizumab?
What is idarucizumab, and how does it work (mechanism of action)?
Dabigatran prevents blood clots by binding to thrombin and preventing thrombin from combining with other proteins to form a blood clot. Dabigatran increases the risk of bleeding because it reduces the ability of blood to clot. Patients who are taking dabigatran may develop serious or life threatening bleeding or may require surgery urgently. In such situations the effect of dabigatran needs to be reversed so that blood can clot normally. Idarucizumab reverses the effect of dabigatran by binding to Pradaxa and preventing it from binding to thrombin, allowing blood to clot normally. The FDA approved idarucizumab on October 2015.
What brand names are available for idarucizumab?
Is idarucizumab available as a generic drug?
Do I need a prescription for idarucizumab?
What are the uses for idarucizumab?
Idarucizumab (Praxbind) is an antibody used for reversing the effect of Pradaxa (dabigatran) for emergency surgery/urgent procedures or if life-threatening or uncontrolled bleeding occurs while taking dabigatran. Dabigatran is an anticoagulant (blood thinner) that is used for preventing blood clots in people with non-valvular atrial fibrillation and for treating deep venous thrombosis (DVT) and pulmonary embolism (PE).
What are the side effects of idarucizumab?
Common side effects of idarucizumab include:
Other reported side effects include:
- Allergic reactions
- Increased levels of laboratory markers for blood clotting
- Idarucizumab antibodies
Possible serious side effects of idarucimab include:
- Reversing the effect of dabigatran removes the protective effect of dabigatran in people who are at risk for blood clots. Therefore, anticoagulation should be started as soon as possible after treatment with idarucizumab.
- If patients continue to bleed or require a second emergency surgery/urgent procedure, an additional 5 g dose of idarucizumab may be considered.
- Idarucizumab contains sorbitol. Patients with hereditary fructose intolerance may be at risk for adverse reactions.
What is the dosage for idarucizumab?
- The recommended dose of idarucizumab is 5 g (2 vials) given as two 2.5 mg intravenous infusions or two injections.
- An additional 5 g may be considered for patients who continue to bleed.
Which drugs or supplements interact with idarucizumab?
- There are no known drug interactions for idarucizumab.
Is idarucizumab safe to take if I'm pregnant or breastfeeding?
What else should I know about idarucizumab?
What preparations of idarucizumab are available?
- Solution for injection: Two single use vials each containing 2.5 g/50 ml.
How should I keep idarucizumab stored?
- Store idarucizumab vials in the refrigerator at 2 C to 8 C (36 F to 46 F).
- Do not freeze.
- Do not shake.
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Idarucizumab (Praxbind) is a prescription drug used to prevent blood clots in people with non-valvular atrial fibrillation and for treating DVT (deep vein thrombosis), and pulmonary embolism. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
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AFib symptoms like heart racing, fluttering, and irregular heart beat may be caused by heart disease, obesity, alcohol use,...
A Visual Guide to Deep Vein Thrombosis (DVT)
Deep vein thrombosis (DVT) is a dangerous and sometimes fatal blood clot that occurs deep within the lower leg or thigh....
DVT (Deep Vein Thrombosis) and Pulmonary Embolism (PE) Quiz
Take the Deep Vein Thrombosis and Pulmonary Embolism Quiz to learn causes, symptoms, and treatments for these two dangerous...
Atrial Fibrillation (A-Fib) Quiz: Test Your Medical IQ
Learn the causes, symptoms, and treatments of the common heart abnormality known as atrial fibrillation (A-fib).
Related Disease Conditions
Blood Clots (in the Leg)
Blood clots can form in the heart, legs, arteries, veins, bladder, urinary tract, and uterus. Risk factors include high blood pressure and cholesterol, diabetes, smoking, and family history. Symptoms and treatment depend on the location of the clot.
Deep Vein Thrombosis (DVT, Blood Clot in the Legs)
Deep vein thrombosis (DVT) is a blood clot in the deep veins, and can be caused by broken bones, trauma to a limb, immobility, medications, smoking, cancer, genetic predisposition, and cancer. Symptoms and signs of a deep vein thrombosis in a leg are swelling, tenderness, redness, warmth, and pain. Treatments for DVT include medications and surgery.
Pulmonary Embolism (Blood Clot in the Lung)
A pulmonary embolism (PE) occurs when a piece of a blood clot from deep vein thrombosis (DVT) breaks off and travels to an artery in the lung where it blocks the artery and damages the lung. The most common symptoms of a pulmonary embolism are shortness of breath, chest pain, and a rapid heart rate. Causes of pulmonary embolism include prolonged immobilization, certain medications, smoking, cancer, pregnancy, and surgery. Pulmonary embolism can cause death if not treated promptly.
Atrial Fibrillation (AFib)
Atrial fibrillation (AF or AFib) is an abnormality in the heart rhythm, which involves irregular and often rapid beating of the heart. Symptoms may include heart palpitations, dizziness, fainting, fatigue, shortness of breath, and chest pain. Atrial fibrillation treatment may include medication or procedures like cardioversion or ablation to normalize the heart rate.
Treatment & Diagnosis
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.