- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- Ibuprofen vs. meloxicam (Mobic) for pain
- What are ibuprofen and meloxicam? How do they work?
- What are the uses for ibuprofen vs. meloxicam?
- What are the side effects of ibuprofen?
- What are the side effects of meloxicam?
- What is the dosage of ibuprofen vs. meloxicam?
- What drugs interact with ibuprofen vs. meloxicam?
- Are ibuprofen and meloxicam safe to take if I am pregnant or breastfeeding?
Ibuprofen vs. meloxicam (Mobic) for pain
- Ibuprofen (Advil, Motrin, and others) and meloxicam (Mobic) are nonsteroidal anti-inflammatory drugs (NSAIDs) used for the management of mild to moderate pain, fever, and inflammation.
- Common side effects of meloxicam and ibuprofen that are similar include:
- Serious side effects of ibuprofen and meloxicam that are similar include fluid retention (edema), blood clots, heart attacks, high blood pressure (hypertension), and heart failure.
- Both ibuprofen and meloxicam may interact with lithium (Lithobid, Eskalith), blood pressure medications, methotrexate (Rheumatrex, Trexall), aminoglycosides, anticoagulants, cyclosporine, furosemide (Lasix), and thiazide diuretics.
- Taking ibuprofen, meloxicam, or other NSAIDs and consuming more than three alcoholic beverages per day may increase the risk of developing stomach ulcers.
- Taking ibuprofen or meloxicam with selective serotonin reuptake inhibitors (SSRIs) may increase the likelihood of gastrointestinal bleeding.
- Meloxicam is available under the brand name Mobic. Brand names of ibuprofen include Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, and PediaCare Fever.
What are ibuprofen and meloxicam? How do they work?
Ibuprofen (Advil, Motrin) and meloxicam (Mobic) belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include indomethacin (Indocin), nabumetone (Relafen), and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. NSAIDs work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation.
Ibuprofen and meloxicam block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. Consequently, inflammation, pain, and fever are reduced.
What are the uses for ibuprofen vs. meloxicam?
Ibuprofen is used for the treatment of mild to moderate pain, inflammation and fever caused by many and diverse diseases. It is used for treating menstrual cramps (dysmenorrhea), osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis.
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What are the side effects of ibuprofen?
The most common side effects from ibuprofen are:
- ringing in the ears,
- abdominal pain,
- constipation, and
NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury.
Ibuprofen may cause ulceration of the stomach or intestine, and the ulcers may bleed. Sometimes, ulceration can occur without abdominal pain; and due to bleeding, the only signs or symptoms of an ulcer may be black, tarry stools, weakness, and dizziness upon standing (orthostatic hypotension).
Sometimes, ulceration can occur without abdominal pain, due to the bleeding, and the only signs or symptoms of an ulcer are:
NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients who already have impaired function of the kidney or congestive heart failure, and use of NSAIDs in these patients should be cautious.
Individuals with asthma are more likely to experience allergic reactions to ibuprofen and other NSAIDs.
Other serious side effects associated with NSAIDs are:
- fluid retention (edema),
- blood clots,
- heart attacks,
- hypertension (high blood pressure), and
- heart failure.
NSAIDs (except low- dose aspirin) may increase the risk of potentially fatal heart attacks, stroke, and related conditions in people with or without heart disease or risk factors for heart disease. The increased risk of heart attack or stroke may occur as early as the first week of use and the risk may increase with longer use and is higher in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.
What are the side effects of meloxicam?
- Individuals who are allergic to NSAIDs may experience shortness of breath when given an NSAID. People with asthma also are at a higher risk for experiencing serious allergic reaction to NSAIDs. Individuals with a serious allergy to one NSAID are likely to experience a similar reaction to a different NSAID.
- New onset or worsening of high blood pressure (hypertension) may occur. Blood pressure should be monitored closely during treatment.
- Meloxicam may cause fluid retention and swelling (edema). It should be used cautiously in people with heart failure.
- Meloxicam may reduce kidney function. Therefore, it should not be used in people with severe kidney failure. It should be used cautiously in the elderly, people with heart failure, liver dysfunction, and those taking diuretics, ACE-inhibitors, or angiotensin II antagonists.
- Serious skin reactions such as exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis (TEN) may occur without warning.
- NSAIDs (except low dose aspirin) may increase the risk of potentially fatal heart attacks, stroke, and related conditions in people with or without heart disease or risk factors for heart disease. The increased risk of heart attack or stroke may occur as early as the first week of use and the risk may increase with longer use and is higher in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.
- Central nervous system effects including drowsiness, dizziness, and blurred vision may occur in patients who are taking an NSAIDs.
Common side effects with NSAIDs are related to the gastrointestinal tract (GI) and include:
To prevent these common side effects, it is recommended that most NSAIDs be taken with food or milk. NSAIDs may cause ulcers in the stomach and/or small intestine. A few NSAIDs are designed to be less damaging to the stomach and small intestine, therefore; they may be taken with or without food. Meloxicam is an example of one of these NSAIDs, but nevertheless, it should be taken cautiously without food. NSAIDs have been associated with an increased risk of blood clots that can cause strokes and heart attacks. NSAIDs also may interfere with the function of the kidneys or injure the kidneys.
Other important side effects of meloxicam are:
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What is the dosage of ibuprofen vs. meloxicam?
- For minor aches, mild to moderate pain, menstrual cramps, and fever, the usual adult dose is 200 or 400 mg every 4 to 6 hours.
- Arthritis is treated with 300 to 800 mg 3 or 4 times daily.
- When under the care of a physician, the maximum dose of ibuprofen is 3.2 g daily. Otherwise, the maximum dose is 1.2 g daily.
- Individuals should not use ibuprofen for more than 10 days for the treatment of pain or more than 3 days for the treatment of a fever unless directed by a physician.
- Children 6 months to 12 years of age usually are given 5-10 mg/kg of ibuprofen every 6-8 hours for the treatment of fever and pain. The maximum dose is 40 mg/kg daily.
- Juvenile arthritis is treated with 20 to 40 mg/kg/day in 3-4 divided doses.
- Ibuprofen should be taken with meals to prevent stomach upset.
The lowest effective dose should be used for each patient. Meloxicam therapy usually is started at 7.5 mg daily. Some patients require a dose of 15 mg daily, but this larger dose should be taken only under the direction of a physician. Juvenile rheumatoid arthritis is treated with 0.125 mg/kg daily up to 7.5 mg per day. Meloxicam may be taken with or without food.
Pain Management Resources
What drugs interact with ibuprofen vs. meloxicam?
Ibuprofen drug and alcohol interactions
Ibuprofen is associated with several suspected or probable interactions that can affect the action of other drugs.
- Ibuprofen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
- Ibuprofen may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
- When ibuprofen is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
- Ibuprofen increases the negative effect of cyclosporine on kidney function.
- Individuals taking oral blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid ibuprofen because ibuprofen also thins the blood, and excessive blood thinning may lead to bleeding.
- If aspirin is taken with ibuprofen there may be an increased risk for developing an ulcer.
- Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking ibuprofen or other NSAIDs.
- Combining SSRIs or selective serotonin reuptake inhibitors (for example, fluoxetine [Prozac], citalopram [Celexa], paroxetine [Paxil, Paxil CR, Pexeva) with NSAIDs may increase the likelihood of upper gastrointestinal bleeding.
Meloxicam drug and alcohol interactions
- Meloxicam may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
- Meloxicam may reduce the blood pressure-lowering effects of drugs given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
- When meloxicam is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
- Meloxicam increases the negative effect of cyclosporine on kidney function and reduces the effect of furosemide (Lasix) and thiazide diuretics because of prostaglandin inhibition.
- Individuals taking oral blood thinners, for example, warfarin (Coumadin, Jantoven), should avoid meloxicam because meloxicam also thins the blood, and excessive blood thinning may lead to bleeding.
- Meloxicam should be avoided by patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs. If aspirin is taken with meloxicam there may be an increased risk for developing a gastrointestinal ulcer.
- Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking meloxicam or other NSAIDs.
- Cholestyramine (Questran), colestipol (Colestid), and colesevelam (Welchol) may decrease the effectiveness of meloxicam by preventing its absorption from the intestine.
- Meloxicam oral suspension contains sorbitol. Combining sodium polystyrene sulfonate (Kayexalate) with sorbitol may cause fatal intestinal necrosis. Therefore, meloxicam oral solution should not be combined with Kayexalate.
Are ibuprofen and meloxicam safe to take if I am pregnant or breastfeeding?
- There are no adequate studies of ibuprofen in pregnant women. Therefore, ibuprofen is not recommended during pregnancy. Ibuprofen should be avoided in late pregnancy due to the risk of premature closure of the ductus arteriosus in the fetal heart.
- Ibuprofen is excreted in breast milk but the American Academy of Pediatrics states that ibuprofen is compatible with breastfeeding.
- There have been no studies of meloxicam therapy in pregnant women. Meloxicam generally should be avoided during the first and second trimester of pregnancy. Because meloxicam may cause a fetal birth defect called ductus arteriosus (early closure of two major blood vessels of the heart and lung) in the third trimester of pregnancy, meloxicam also should be avoided during this last part of pregnancy.
- There have been no studies in humans to determine if meloxicam is excreted in breast milk.
Ibuprofen (Advil, Motrin, and many other brand names) and meloxicam (Mobic)
belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs),
and are used to manage mild to moderate pain, inflammation, and fever. NSAIDs
block enzymes that make chemicals that contribute to inflammation
(prostaglandins), which reduces prostaglandin levels and thus inflammation. Meloxicam is a
prescription drug and is stronger than ibuprofen (which is available
over-the-counter (OTC) at relieving pain and inflammation.
Common side effects of both ibuprofen and meloxicam include heartburn, constipation, drowsiness, dizziness, abdominal pain, tinnitus, rash, nausea, and diarrhea. Both NSAIDs have serious side effects that include edema, blood clots, heart attacks, high blood pressure, heart failure, and stomach ulcers.
Other side effects of meloxicam include intestinal gas, headache, joint pain,
back pain, insomnia, itching, bladder infection, skin rash, and upper
respiratory tract infection.
The dosage for ibuprofen is 1 to 2 tablets every 4 to 6 hours. No more than 6 tablets should be taken in 24 hours unless advised by a doctor or other healthcare professional. Meloxicam is only taken once a day. Dosage depends upon the condition being treated.
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Related Disease Conditions
Inner Ear Infection (Symptoms, Signs, Treatments, Home Remedies)
An inner ear infection or otitis interna is caused by viruses or bacteria and can occur in both adults and children. An inner ear infection can cause symptoms and signs, for example, a severe ear, dizziness, vertigo, nausea and vomiting, and vertigo. An inner ear infection also may cause inflammation of the inner ear or labyrinthitis. Inner ear infections are not contagious; however, the bacteria and viruses that cause the infection can be transmitted to other people. Good hygiene practices will help decrease the chances of the infection spreading to others. Inner ear infection symptoms and signs like ear pain and nausea may be relieved with home remedies or over the counter (OTC) medication. Some inner ear infections will need to be treated and cured with antibiotics or prescription pain or antinausea medication.
Fever in Adults and Children
Although a fever technically is any body temperature above the normal of 98.6 F (37 C), in practice, a person is usually not considered to have a significant fever until the temperature is above 100.4 F (38 C). Fever is part of the body's own disease-fighting arsenal; rising body temperatures apparently are capable of killing off many disease-producing organisms.
Lower Back Pain
There are many causes of back pain. Pain in the low back can relate to the bony lumbar spine, discs between the vertebrae, ligaments around the spine and discs, spinal cord and nerves, muscles of the low back, internal organs of the pelvis and abdomen, and the skin covering the lumbar area.
Shoulder and Neck Pain
Shoulder and neck pain may be caused by bursitis, a pinched nerve, whiplash, tendinitis, a herniated disc, or a rotator cuff injury. Symptoms also include weakness, numbness, coolness, color changes, swelling, and deformity. Treatment at home may incorporate resting, icing, and elevating the injury. A doctor may prescribe pain medications and immobilize the injury.
Foot pain may be caused by injuries (sprains, strains, bruises, and fractures), diseases (diabetes, Hansen disease, and gout), viruses, fungi, and bacteria (plantar warts and athlete's foot), or even ingrown toenails. Pain and tenderness may be accompanied by joint looseness, swelling, weakness, discoloration, and loss of function. Minor foot pain can usually be treated with rest, ice, compression, and elevation and OTC medications such as acetaminophen and ibuprofen. Severe pain should be treated by a medical professional.
Ear Infection Home Treatment
Infections of the outer, middle, and inner ear usually are caused by viruses. Most outer (swimmer's ear) and middle ear (otitis media) infections can be treated at home with remedies like warm compresses for ear pain relief, tea tree, ginger, or garlic oil drops. Symptoms of an outer ear (swimmer's ear) and middle ear infection include mild to severe ear pain, pus draining from the ear, swelling and redness in the ear, and hearing problems. Middle and inner ear infections may cause fever, and balance problems. Inner ear infections also may cause nausea, vomiting, vertigo, ringing in the ear, and labyrinthitis (inflammation of the inner ear). Most outer and middle ear infections do not need antibiotics. Inner ear infections should be treated by a doctor specializing in ear and hearing problems.
Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints, the tissue around the joints, as well as other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. The 16 characteristic early RA signs and symptoms include the following. Anemia Both sides of the body affected (symmetric) Depression Fatigue Fever Joint deformity Joint pain Joint redness Joint stiffness Joint swelling Joint tenderness Joint warmth Limping Loss of joint function Loss of joint range of motion Many joints affected (polyarthritis)
Ankle Pain (Tendinitis)
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Arthritis (Joint Inflammation)
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Inner Ear Infection (Labyrinthitis)
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Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Arthritis, bursitis, IT band syndrome, fracture, and strain are just some of the causes of hip pain. Associated symptoms and signs include swelling, tenderness, difficulty sleeping on the hip, and loss of range of motion of the hip. Treatment depends upon the cause of the hip pain but may include anti-inflammatory medications and icing and resting the hip joint.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
Rheumatoid Arthritis vs. Fibromyalgia
Though rheumatoid arthritis (RA) and fibromyalgia have similar symptoms, RA is an autoimmune disease and fibromyalgia is a chronic pain syndrome. RA symptoms include joint redness, swelling, and pain that lasts more than six weeks. Fibromyalgia symptoms include widespread pain, tingling feet or hands, depression, and bowel irritability. Home remedies for both include stress reduction, exercise, and getting enough sleep.
Migraine and Stroke (Symptoms, Types, Causes, Treatment)
Migraine headache is a type of headache in which the exact cause is not known; however, they may be inherited, and certain foods and environmental factors can trigger and may contribute them. A stroke (brain attack) happens when a blood vessel in the brain leaks, bursts, or becomes blocked, which can be caused by many other health problems. Both migraines and strokes can can cause severe head pain (migraine pain usually is only on one side of the head). Migraine aura symptoms may mimic or feel like a stroke or mini-stroke (transient ischemic attack, TIA) because they have similar symptoms and signs like severe headache, numbness in the legs, feet, arms, hands, or face, nausea, vomiting, and dizziness. Other migraine aura symptoms include vision problems like flashing lights or blind spots in one eye. The main difference between migraine headache and stroke symptoms and signs is that a migraine headaches usually come on gradually while a stroke symptoms come on suddenly and unexpectedly. A migraine may cause photophobia (sensitivity to light and sound). Migraine triggers include hormonal changes, alcohol, insomnia, caffeine, stress, anxiety, bright lights, loud noises, strong odors, aspartame, MSG, and changes in the weather. Symptoms of a stroke that do not occur with migraines include confusion, speech, vision, and balance problems. You can have a migraine headache and a stroke at the same time, but migraines do not cause strokes. However, in certain individuals with migraines with auras there may be related to a higher risk of stroke. Stroke is a medical emergency. If you have stroke symptoms, call 9-1-1 and get medical attention immediately.
Juvenile Rheumatoid Arthritis (JRA)
Juvenile rheumatoid arthritis (JRA) annually affects one child in every thousand. There are six types of JRA. Treatment of juvenile arthritis depends upon the type the child has and should focus on treating the symptoms that manifest.
Treatment & Diagnosis
Medications & Supplements
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- ibuprofen (Advil, Motrin, Nuprin)
- Acetaminophen vs. Ibuprofen for Pain (Differences in Side Effects and Dosage)
- meloxicam (Mobic) Side Effects
- celecoxib (Celebrex)
- Ibuprofen (Advil) vs. Naproxen (Aleve): Comparison of Differences
- Ketorolac vs. ibuprofen (Advil)
- Ibuprofen and Plavix (Side Effects and Interactions)
- Ketorolac vs. diclofenac
- Ketorolac vs. hydrocodone
- Ketorolac vs. naproxen (Aleve)
- Ketorolac vs. ketoprofen
- hydrocodone and ibuprofen, Vicoprofen
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